HUMAN:TLR9

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TLR9
Protein Name(s)	Toll-like receptor 9
External Links
UniProt	Q9NR96
EMBL	AF259262 AF259263 AF245704 AF246972 AF246973 AF246974 AB045180 EU170540 EU170541 EU170542 EU170543 AB445673 DQ019992 DQ019993 DQ019994 DQ019995 DQ019996 DQ019999 AY359085 CH471055 BC032713
CCDS	CCDS2848.1
RefSeq	NP_059138.1
UniGene	Hs.87968
ProteinModelPortal	Q9NR96
SMR	Q9NR96
BioGrid	119902
IntAct	Q9NR96
STRING	9606.ENSP00000353874
BindingDB	Q9NR96
ChEMBL	CHEMBL2111471
DrugBank	DB00608 DB01611
GuidetoPHARMACOLOGY	1759
PhosphoSite	Q9NR96
DMDM	20140872
MaxQB	Q9NR96
PaxDb	Q9NR96
PRIDE	Q9NR96
DNASU	54106
Ensembl	ENST00000360658
GeneID	54106
KEGG	hsa:54106
UCSC	uc003dda.2
CTD	54106
GeneCards	GC03M052255
H-InvDB	HIX0163454
HGNC	HGNC:15633
HPA	HPA004731
MIM	605474
neXtProt	NX_Q9NR96
PharmGKB	PA38010
eggNOG	COG4886
GeneTree	ENSGT00760000119006
HOVERGEN	HBG018601
InParanoid	Q9NR96
KO	K10161
OrthoDB	EOG7C8GGD
PhylomeDB	Q9NR96
TreeFam	TF325595
Reactome	REACT_118632 REACT_25024 REACT_25120 REACT_25222 REACT_9047 REACT_976
ChiTaRS	TLR9
GeneWiki	TLR9
GenomeRNAi	54106
NextBio	56466
PRO	PR:Q9NR96
Proteomes	UP000005640
Bgee	Q9NR96
CleanEx	HS_TLR9
ExpressionAtlas	Q9NR96
Genevestigator	Q9NR96
GO	GO:0016324 GO:0016323 GO:0005737 GO:0032009 GO:0036020 GO:0005783 GO:0005789 GO:0005768 GO:0010008 GO:0005576 GO:0000139 GO:0016021 GO:0005764 GO:0005886 GO:0005149 GO:0035197 GO:0004888 GO:0042742 GO:0050829 GO:0007252 GO:0006954 GO:0045087 GO:0008286 GO:0030277 GO:0002755 GO:0032715 GO:0032717 GO:0032088 GO:0034122 GO:0032722 GO:0043123 GO:0050729 GO:0045356 GO:0045359 GO:0032728 GO:0045078 GO:0032733 GO:0032735 GO:0032741 GO:0032755 GO:0032757 GO:0046330 GO:0043507 GO:0042346 GO:0051092 GO:0051770 GO:0034123 GO:0045944 GO:0032760 GO:0050707 GO:0002237 GO:0034162 GO:0002224
Gene3D	3.40.50.10140
InterPro	IPR001611 IPR003591 IPR000157 IPR027181
PANTHER	PTHR24373:SF37
Pfam	PF00560 PF13504 PF13855 PF01582
SMART	SM00369
SUPFAM	SSF52200
PROSITE	PS51450 PS50104

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0032755	positive regulation of interleukin-6 production	PMID:24409285^[1]	ECO:0000314			P	In figure 2A both CpG-ODN and Poly LL are agonists of TLR9 and when added increase the amount of Interleukin 6 produced in End1/E6E7 cells.	complete CACAO 9269
	GO:0032757	positive regulation of interleukin-8 production	PMID:24409285^[1]	ECO:0000314			P	In figure 2A both CpG-ODN and Poly LL are agonists of TLR9 and when added increase the amount of Interleukin 8 produced in End1/E6E7 cells.	complete CACAO 9271
	GO:0010628	positive regulation of gene expression	PMID:24409285^[1]	ECO:0000314			P	In figure 3A graph 1 and figure 3B show that when compared to the control, cells that are subjected to agnoists of TLR9 show an increased expression of p65-NF-kB in End1/E6E7 cells. This suggests that TLR9 activation leads to increased expression of P65-NF-kB.	complete CACAO 9278
	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	PMID:24409285^[1]	ECO:0000314			P	Figure 4 A and B show that when subjected to agonists TLR9 increases the production of GM-CSF in End1/E6E7 cells when compared to the control.	complete CACAO 9279
	GO:0032640	tumor necrosis factor production	PMID:23826189^[2]	ECO:0000314			P	Fiugre 1:Two samples of mononuclear cells were collected, TLR 9 agonist was added in one sample, and absent in another. Levels of TNF Alpha were measured respectively and seen higher when induced with the agonist.	complete CACAO 9868
	GO:1901895	negative regulation of calcium-transporting ATPase activity	PMID:24610369^[3]	ECO:0000314			P	Figure 3b demonstrates the measurement of Ca2+ ATPase activity of sarcoplasmic reticulum Ca2+ ATPase (SERCA2) with and without toll like receptor 9 (TLR9) stimulation. TLR9 stimulation showed to reduce SERCA2 uptake activity of calcium from cytosol to endoplasmic/sarcoplasmic reticulum (ER/SR) and regulate storage of calcium in ER/SR. Figure 4 demonstrates how the reduction of calcium by TLR9 inhibiting SERCA2 decreases mitochondrial ATP levels leading to increased cellular protection during an immune response.	complete CACAO 9957
part_of	GO:0036019	endolysosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	C	Seeded From UniProt	complete
involved_in	GO:0045577	regulation of B cell differentiation	PMID:23857366^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002639	positive regulation of immunoglobulin production	PMID:23857366^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:23857366^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034163	regulation of toll-like receptor 9 signaling pathway	PMID:23857366^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050871	positive regulation of B cell activation	PMID:23857366^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:23857366^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0045322	unmethylated CpG binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2EEY0	F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2EEY0	F	Seeded From UniProt	complete
involved_in	GO:1901895	negative regulation of calcium-transporting ATPase activity	PMID:24610369^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032640	tumor necrosis factor production	PMID:23826189^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:24409285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:24409285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	PMID:24409285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24409285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:22427638^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:19740627^[7]	ECO:0000305	curator inference used in manual assertion	GO:1901224	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:17128265^[6]	ECO:0000305	curator inference used in manual assertion	GO:0043507	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	P	Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:19740627^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034123	positive regulation of toll-like receptor signaling pathway	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034122	negative regulation of toll-like receptor signaling pathway	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	P	Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:19740627^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:19740627^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032741	positive regulation of interleukin-18 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	P	Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	P	Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	P	Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	P	Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	PMID:19740627^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032717	negative regulation of interleukin-8 production	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	P	Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030277	maintenance of gastrointestinal epithelium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:17128265^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	PMID:19740627^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19740627^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19740627^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045359	positive regulation of interferon-beta biosynthetic process	PMID:16286015^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045356	positive regulation of interferon-alpha biosynthetic process	PMID:16286015^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045078	positive regulation of interferon-gamma biosynthetic process	PMID:16286015^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:11130078^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	PMID:15723075^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0032009	early phagosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9EQU3	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:11130078^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	PMID:12925853^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6IA17	F	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1932389 MGI:MGI:2176882 PANTHER:PTN002934106 RGD:631352 UniProtKB:Q9NR97 UniProtKB:Q9NYK1	P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1932389 PANTHER:PTN002934107 UniProtKB:Q2EEY0 UniProtKB:Q5I2M5 UniProtKB:Q9NR96	P	Seeded From UniProt	complete
involved_in	GO:0045416	positive regulation of interleukin-8 biosynthetic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934106 UniProtKB:Q9NR97 UniProtKB:Q9NYK1	P	Seeded From UniProt	complete
involved_in	GO:0045359	positive regulation of interferon-beta biosynthetic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934106 UniProtKB:Q9NR96 UniProtKB:Q9NR97 UniProtKB:Q9NYK1	P	Seeded From UniProt	complete
involved_in	GO:0045078	positive regulation of interferon-gamma biosynthetic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934106 UniProtKB:Q9NR96 UniProtKB:Q9NR97 UniProtKB:Q9NYK1	P	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1932389 MGI:MGI:2176882 PANTHER:PTN002934106 UniProtKB:Q9NR96	P	Seeded From UniProt	complete
involved_in	GO:0032640	tumor necrosis factor production	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1932389 PANTHER:PTN002934107 UniProtKB:Q9NR96	P	Seeded From UniProt	complete
enables	GO:0008329	signaling pattern recognition receptor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934106 UniProtKB:Q2EEY0 UniProtKB:Q5I2M5	F	Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1932389 PANTHER:PTN002934106 UniProtKB:Q9NR97	P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1932389 PANTHER:PTN002934106	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1932389 PANTHER:PTN002934106 RGD:631352 UniProtKB:Q2EEY0 UniProtKB:Q9NR96 UniProtKB:Q9NYK1	C	Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002934106 RGD:1563357 RGD:1590327 RGD:631352 ZFIN:ZDB-GENE-040219-10	P	Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027181	P	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027181	P	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027181	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000157	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027181	C	Seeded From UniProt	complete
involved_in	GO:0034162	toll-like receptor 9 signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027181	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027181	P	Seeded From UniProt	complete
involved_in	GO:0050707	regulation of cytokine secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027181	P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027181	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:15356140^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	PMID:15356140^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0036020	endolysosome membrane	Reactome:R-HSA-1678981 Reactome:R-HSA-1678927 Reactome:R-HSA-1678920	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0034162	toll-like receptor 9 signaling pathway	Reactome:R-HSA-168138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	Reactome:R-HSA-975188 Reactome:R-HSA-975180 Reactome:R-HSA-975175 Reactome:R-HSA-975170 Reactome:R-HSA-975160 Reactome:R-HSA-975156 Reactome:R-HSA-975134 Reactome:R-HSA-975125 Reactome:R-HSA-975118 Reactome:R-HSA-975115 Reactome:R-HSA-975111 Reactome:R-HSA-975106 Reactome:R-HSA-975100 Reactome:R-HSA-975098 Reactome:R-HSA-188002 Reactome:R-HSA-187895 Reactome:R-HSA-1679589 Reactome:R-HSA-1679098 Reactome:R-HSA-109699	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-1678998 Reactome:R-HSA-1678944 Reactome:R-HSA-1678923 Reactome:R-HSA-1678921	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	Reactome:R-HSA-168898 Reactome:R-HSA-168181	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-1678998 Reactome:R-HSA-1678927	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0206	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Sathe, A & Reddy, KV (2014) TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro. PLoS ONE 9 e83882 PubMed GONUTS page
↑ ^2.0 ^2.1 Cardoso, EC et al. (2013) TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns. PLoS ONE 8 e67036 PubMed GONUTS page
↑ ^3.0 ^3.1 Shintani, Y et al. (2014) Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2. EMBO Rep. 15 438-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Li, FJ et al. (2013) FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation. Eur. J. Immunol. 43 2980-92 PubMed GONUTS page
↑ So, NS et al. (2012) Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae. J. Immunol. 188 4008-22 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Lee, J et al. (2006) Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 8 1327-36 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Yu, N et al. (2009) Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J. Dermatol. Sci. 56 113-20 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yang, K et al. (2005) Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity 23 465-78 PubMed GONUTS page
↑ ^9.0 ^9.1 Hemmi, H et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408 740-5 PubMed GONUTS page
↑ Hornung, V et al. (2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11 263-70 PubMed GONUTS page
↑ Wald, D et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 4 920-7 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page

[PMID:24409285-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Sathe, A & Reddy, KV (2014) TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro. PLoS ONE 9 e83882 PubMed GONUTS page

[PMID:23826189-2] 2.0 ^2.1 Cardoso, EC et al. (2013) TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns. PLoS ONE 8 e67036 PubMed GONUTS page

[PMID:24610369-3] 3.0 ^3.1 Shintani, Y et al. (2014) Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2. EMBO Rep. 15 438-45 PubMed GONUTS page

[PMID:23857366-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Li, FJ et al. (2013) FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation. Eur. J. Immunol. 43 2980-92 PubMed GONUTS page

[PMID:22427638-5] So, NS et al. (2012) Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae. J. Immunol. 188 4008-22 PubMed GONUTS page

[PMID:17128265-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Lee, J et al. (2006) Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 8 1327-36 PubMed GONUTS page

[PMID:19740627-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Yu, N et al. (2009) Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J. Dermatol. Sci. 56 113-20 PubMed GONUTS page

[PMID:16286015-8] 8.0 ^8.1 ^8.2 Yang, K et al. (2005) Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity 23 465-78 PubMed GONUTS page

[PMID:11130078-9] 9.0 ^9.1 Hemmi, H et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408 740-5 PubMed GONUTS page

[PMID:15723075-10] Hornung, V et al. (2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11 263-70 PubMed GONUTS page

[PMID:12925853-11] Wald, D et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 4 920-7 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15356140-13] 13.0 ^13.1 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page

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