MOUSE:UN93B

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Unc93b1 (synonyms: Unc93b)
Protein Name(s)	Protein unc-93 homolog B1 Unc-93B1
External Links
UniProt	Q8VCW4
EMBL	AK165060 BC018388 BC023731 BC025587 AJ422144 U89424
RefSeq	NP_001154900.1 NP_062322.2
UniGene	Mm.262094
ProteinModelPortal	Q8VCW4
IntAct	Q8VCW4
STRING	10090.ENSMUSP00000040093
PhosphoSite	Q8VCW4
MaxQB	Q8VCW4
PaxDb	Q8VCW4
PRIDE	Q8VCW4
GeneID	54445
KEGG	mmu:54445
UCSC	uc008fxt.1
CTD	81622
MGI	MGI:1859307
eggNOG	NOG294869
HOGENOM	HOG000132956
HOVERGEN	HBG084638
InParanoid	Q8VCW4
Reactome	REACT_198976
NextBio	311310
PRO	PR:Q8VCW4
Proteomes	UP000000589
Bgee	Q8VCW4
CleanEx	MM_UNC93B1
ExpressionAtlas	Q8VCW4
Genevestigator	Q8VCW4
GO	GO:0032009 GO:0005783 GO:0005789 GO:0005768 GO:0016021 GO:0005764 GO:0035325 GO:0019886 GO:0051607 GO:0045087 GO:0006886 GO:0034138 GO:0034154 GO:0034162 GO:0002224
InterPro	IPR010291
Pfam	PF05978

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0035325	Toll-like receptor binding	PMID:17452530^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6R5N8	F		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	PMID:17452530^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9EQU3	F		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	PMID:17452530^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P58681	F		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	PMID:17452530^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99MB1	F		Seeded From UniProt	complete
involved_in	GO:0034162	toll-like receptor 9 signaling pathway	PMID:16415873^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034154	toll-like receptor 7 signaling pathway	PMID:16415873^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034138	toll-like receptor 3 signaling pathway	PMID:16415873^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032009	early phagosome	PMID:18305481^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	PMID:18305481^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17452530^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:18305481^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:18305481^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790	F		Seeded From UniProt	complete
involved_in	GO:0034162	toll-like receptor 9 signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790 UniProtKB:Q9H1C4	P		Seeded From UniProt	complete
involved_in	GO:0034154	toll-like receptor 7 signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790 UniProtKB:Q9H1C4	P		Seeded From UniProt	complete
involved_in	GO:0034138	toll-like receptor 3 signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790 UniProtKB:Q9H1C4	P		Seeded From UniProt	complete
part_of	GO:0032009	early phagosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790	C		Seeded From UniProt	complete
enables	GO:0008565	obsolete protein transporter activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790	F		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790 UniProtKB:Q9H1C4	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790 UniProtKB:Q9H1C4	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859307 PANTHER:PTN002928790	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001184	positive regulation of interleukin-12 secretion	PMID:20457904^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000778	positive regulation of interleukin-6 secretion	PMID:20457904^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034162	toll-like receptor 9 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1C4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034154	toll-like receptor 7 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1C4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034138	toll-like receptor 3 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1C4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	PMID:16415873^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619211	P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019882	antigen processing and presentation	PMID:20457904^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619211	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:16415873^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1C4	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1C4	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002224	toll-like receptor signaling pathway	PMID:16415873^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619211	P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	PMID:20457904^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619211	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0206	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Brinkmann, MM et al. (2007) The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J. Cell Biol. 177 265-75 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Tabeta, K et al. (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7 156-64 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Kim, YM et al. (2008) UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452 234-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Eidenschenk, C et al. (2010) Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc. Natl. Acad. Sci. U.S.A. 107 9759-64 PubMed GONUTS page

[PMID:17452530-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Brinkmann, MM et al. (2007) The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J. Cell Biol. 177 265-75 PubMed GONUTS page

[PMID:16415873-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Tabeta, K et al. (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7 156-64 PubMed GONUTS page

[PMID:18305481-3] 3.0 ^3.1 ^3.2 ^3.3 Kim, YM et al. (2008) UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452 234-8 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20457904-5] 5.0 ^5.1 ^5.2 ^5.3 Eidenschenk, C et al. (2010) Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc. Natl. Acad. Sci. U.S.A. 107 9759-64 PubMed GONUTS page

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MOUSE:UN93B

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