GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16415873
| Citation |
Tabeta, K, Hoebe, K, Janssen, EM, Du, X, Georgel, P, Crozat, K, Mudd, S, Mann, N, Sovath, S, Goode, J, Shamel, L, Herskovits, AA, Portnoy, DA, Cooke, M, Tarantino, LM, Wiltshire, T, Steinberg, BE, Grinstein, S and Beutler, B (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7:156-64 |
|---|---|
| Abstract |
Here we have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 (sensors for double-stranded RNA, single-stranded RNA and unmethylated DNA, respectively). The 3d mutation also prevented cross-presentation and diminished major histocompatibility complex class II presentation of exogenous antigen; it also caused hypersusceptibility to infection by mouse cytomegalovirus and other microbes. By positional identification, we found 3d to be a missense allele of Unc93b1, which encodes the 12-membrane-spanning protein UNC-93B, a highly conserved molecule found in the endoplasmic reticulum with multiple paralogs in mammals. Innate responses to nucleic acids and exogenous antigen presentation, which both initiate in endosomes, thus seem to depend on an endoplasmic reticulum-resident protein, which suggests communication between these organellar systems. |
| Links |
PubMed Online version:10.1038/ni1297 |
| Keywords |
Animals; Antigen Presentation/genetics; Cloning, Molecular; Endoplasmic Reticulum/metabolism; Endosomes/metabolism; Histocompatibility Antigens Class II/metabolism; Infection/genetics; Infection/immunology; Membrane Glycoproteins/metabolism; Membrane Transport Proteins/genetics; Membrane Transport Proteins/immunology; Membrane Transport Proteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation, Missense; Phenotype; Signal Transduction/genetics; Toll-Like Receptor 3/metabolism; Toll-Like Receptor 7/metabolism; Toll-Like Receptor 9/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
