HUMAN:KS6A3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RPS6KA3 (synonyms: ISPK1, MAPKAPK1B, RSK2)
Protein Name(s)	Ribosomal protein S6 kinase alpha-3 S6K-alpha-3 90 kDa ribosomal protein S6 kinase 3 p90-RSK 3 p90RSK3 Insulin-stimulated protein kinase 1 ISPK-1 MAP kinase-activated protein kinase 1b MAPK-activated protein kinase 1b MAPKAP kinase 1b MAPKAPK-1b Ribosomal S6 kinase 2 RSK-2 pp90RSK2
External Links
UniProt	P51812
EMBL	U08316 AK313932 AB208933 AL732366 AL807772 AL807772 AL732366 BC096301 BC096302 BC096303 L07599 AB102662
CCDS	CCDS14197.1
PIR	I38556
RefSeq	NP_004577.1
UniGene	Hs.445387
PDB	4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6
PDBsum	4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6
ProteinModelPortal	P51812
SMR	P51812
BioGrid	112111
DIP	DIP-38247N
IntAct	P51812
MINT	MINT-1542962
STRING	9606.ENSP00000368884
BindingDB	P51812
ChEMBL	CHEMBL2345
DrugBank	DB00945
GuidetoPHARMACOLOGY	1528
PhosphoSite	P51812
DMDM	1730070
MaxQB	P51812
PaxDb	P51812
PeptideAtlas	P51812
PRIDE	P51812
DNASU	6197
Ensembl	ENST00000379565
GeneID	6197
KEGG	hsa:6197
UCSC	uc004czu.3
CTD	6197
GeneCards	GC0XM020168
GeneReviews	RPS6KA3
HGNC	HGNC:10432
HPA	CAB003853 CAB013520 HPA003221
MIM	300075 300844 303600
neXtProt	NX_P51812
Orphanet	192 777
PharmGKB	PA34847
eggNOG	COG0515
GeneTree	ENSGT00770000120454
HOGENOM	HOG000233033
HOVERGEN	HBG108317
InParanoid	P51812
KO	K04373
OMA	HPWIVHC
OrthoDB	EOG7B8S38
PhylomeDB	P51812
TreeFam	TF313438
BRENDA	2.7.11.1
Reactome	REACT_120966 REACT_12524 REACT_12599 REACT_169168 REACT_20510 REACT_20568 REACT_22365
SignaLink	P51812
ChiTaRS	RPS6KA3
GeneWiki	RPS6KA3
GenomeRNAi	6197
NextBio	24069
PRO	PR:P51812
Proteomes	UP000005640
Bgee	P51812
CleanEx	HS_RPS6KA3
ExpressionAtlas	P51812
Genevestigator	P51812
GO	GO:0005829 GO:0005654 GO:0005524 GO:0043027 GO:0000287 GO:0004672 GO:0004674 GO:0007411 GO:0007049 GO:0007417 GO:0045087 GO:0002755 GO:0002756 GO:0043066 GO:0043154 GO:0048011 GO:0045597 GO:0030307 GO:0045944 GO:0043620 GO:0043555 GO:0032496 GO:0007165 GO:0001501 GO:0051403 GO:0007268 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666
InterPro	IPR000961 IPR011009 IPR017892 IPR000719 IPR017441 IPR016239 IPR002290 IPR008271
Pfam	PF00069 PF00433
PIRSF	PIRSF000606
SMART	SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22065586^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18402937^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	PMID:18402937^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18654	P		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18654	P		Seeded From UniProt	complete
enables	GO:0004711	ribosomal protein S6 kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262866 MGI:MGI:1342290 PANTHER:PTN001219146	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043027	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18654 ensembl:ENSMUSP00000033671	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18654 ensembl:ENSMUSP00000033671	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18654 ensembl:ENSMUSP00000033671	F		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18654 ensembl:ENSMUSP00000033671	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016239	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR016239 InterPro:IPR017892	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR016239 InterPro:IPR017892	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016239	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:11404397^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P16220)	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:10319851^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10436156^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8141249^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10436156^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:8955270^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	PMID:18813292^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043620	regulation of DNA-templated transcription in response to stress	PMID:18813292^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043555	regulation of translation in response to stress	PMID:18813292^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:18813292^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:18813292^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9029434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-3876071 Reactome:R-HSA-9029434 Reactome:R-HSA-442724 Reactome:R-HSA-199895 Reactome:R-HSA-198746	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page
↑ ^2.0 ^2.1 Chen, J et al. (2008) Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation. Exp. Neurol. 211 529-38 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page
↑ Merienne, K et al. (1999) A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation. Nat. Genet. 22 13-4 PubMed GONUTS page
↑ ^6.0 ^6.1 Sassone-Corsi, P et al. (1999) Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285 886-91 PubMed GONUTS page
↑ Moller, DE et al. (1994) Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol. 266 C351-9 PubMed GONUTS page
↑ Trivier, E et al. (1996) Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Nature 384 567-70 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Anjum, R & Blenis, J (2008) The RSK family of kinases: emerging roles in cellular signalling. Nat. Rev. Mol. Cell Biol. 9 747-58 PubMed GONUTS page

[PMID:22065586-1] Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page

[PMID:18402937-2] 2.0 ^2.1 Chen, J et al. (2008) Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation. Exp. Neurol. 211 529-38 PubMed GONUTS page

[PMID:21873635-3] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11404397-4] Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page

[PMID:10319851-5] Merienne, K et al. (1999) A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation. Nat. Genet. 22 13-4 PubMed GONUTS page

[PMID:10436156-6] 6.0 ^6.1 Sassone-Corsi, P et al. (1999) Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285 886-91 PubMed GONUTS page

[PMID:8141249-7] Moller, DE et al. (1994) Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol. 266 C351-9 PubMed GONUTS page

[PMID:8955270-8] Trivier, E et al. (1996) Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Nature 384 567-70 PubMed GONUTS page

[PMID:18813292-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Anjum, R & Blenis, J (2008) The RSK family of kinases: emerging roles in cellular signalling. Nat. Rev. Mol. Cell Biol. 9 747-58 PubMed GONUTS page

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HUMAN:KS6A3

Contents

Annotations

Notes

References

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