HUMAN:HMGB1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HMGB1 (synonyms: HMG1)
Protein Name(s)	High mobility group protein B1 High mobility group protein 1 HMG-1
External Links
UniProt	P09429
EMBL	X12597 U51677 D63874 EF157968 AY377859 AK291494 AK122825 CR749614 CR456863 BT006940 BT020159 EU012027 AL353648 CH471075 BC003378 BC030981 BC066889 BC067732 BC141844
CCDS	CCDS9335.1
PIR	S02826
RefSeq	NP_002119.1 XP_005266420.1 XP_005266422.1
UniGene	Hs.434102 Hs.593339 Hs.596078
PDB	2LY4 2RTU 2YRQ
PDBsum	2LY4 2RTU 2YRQ
ProteinModelPortal	P09429
SMR	P09429
BioGrid	109389
DIP	DIP-24195N
IntAct	P09429
MINT	MINT-153055
STRING	9606.ENSP00000343040
BindingDB	P09429
ChEMBL	CHEMBL2311236
PhosphoSite	P09429
DMDM	123369
DOSAC-COBS-2DPAGE	P09429
MaxQB	P09429
PaxDb	P09429
PeptideAtlas	P09429
PRIDE	P09429
DNASU	3146
Ensembl	ENST00000339872 ENST00000341423 ENST00000399494 ENST00000405805
GeneID	3146
KEGG	hsa:3146
UCSC	uc001usx.3
CTD	3146
GeneCards	GC13M031032
H-InvDB	HIX0030745
HGNC	HGNC:4983
HPA	CAB005873 HPA003506
MIM	163905
neXtProt	NX_P09429
PharmGKB	PA188
eggNOG	COG5648
GeneTree	ENSGT00760000119164
HOGENOM	HOG000197861
HOVERGEN	HBG009000
InParanoid	P09429
KO	K10802
OMA	RTKGKVD
OrthoDB	EOG7WHHBQ
PhylomeDB	P09429
TreeFam	TF105371
Reactome	REACT_118563 REACT_13462 REACT_21281 REACT_24969 REACT_25195
ChiTaRS	HMGB1
EvolutionaryTrace	P09429
GeneWiki	HMGB1
GenomeRNAi	3146
NextBio	12470
PRO	PR:P09429
Proteomes	UP000005640
Bgee	P09429
CleanEx	HS_HMGB1
ExpressionAtlas	P09429
Genevestigator	P09429
GO	GO:0009986 GO:0000793 GO:0005576 GO:0005615 GO:0005654 GO:0005634 GO:0042056 GO:0005125 GO:0003684 GO:0008301 GO:0003690 GO:0044822 GO:0050786 GO:0070491 GO:0003700 GO:0003697 GO:0008134 GO:0006309 GO:0006915 GO:0006288 GO:0006921 GO:0002407 GO:0051103 GO:0006310 GO:0006265 GO:0002437 GO:0045087 GO:0001773 GO:2000426 GO:0017055 GO:0000122 GO:0031175 GO:0050918 GO:0043065 GO:0043280 GO:0043388 GO:0045944 GO:0006357 GO:0033151
Gene3D	1.10.30.10
InterPro	IPR009071 IPR017967
Pfam	PF00505 PF09011
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS00353 PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043537	negative regulation of blood vessel endothelial cell migration	PMID:23148224^[1]	ECO:0000314			P		Figure 2 shows that HMGB1 inhibits HPAEC migration, which is a critical process for vascular regeneration.	complete CACAO 5868
	GO:0006954	inflammatory response	PMID:23146691^[2]	ECO:0000314			P		Figure 2	complete CACAO 5992
	GO:0080111	DNA demethylation	PMID:24082908^[3]	ECO:0000314			P		Figure 3 shows the expression of HMGB1 in normal and SLE CD4+ T cells.	complete CACAO 9360
	GO:0032755	positive regulation of interleukin-6 production	PMID:26961863^[4]	ECO:0000314			P		Figure 1b	complete CACAO 11517
	GO:0032757	positive regulation of interleukin-8 production	PMID:26961863^[4]	ECO:0000314			P		Figure 5b shows increased Interleukin-8 secretion when HMGB1 is added.	complete CACAO 11518
	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	PMID:26961863^[4]	ECO:0000314			P		Figure 5a	complete CACAO 11519
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:28276476^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_movement_of:(CL:0002546)	Seeded From UniProt	complete
involved_in	GO:1905564	positive regulation of vascular endothelial cell proliferation	PMID:28276476^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_division_of:(CL:0002546)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19158276^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P07305	P		Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:19158276^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P07305	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19158276^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P01375)	Seeded From UniProt	complete
part_of	GO:0035868	alphav-beta3 integrin-HMGB1 complex	PMID:20826760^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:20826760^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63158	P	occurs_in:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63158	C	part_of:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63158	C	produced_by:(CL:0000129) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0051106	positive regulation of DNA ligation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63159	P		Seeded From UniProt	complete
involved_in	GO:0043277	apoptotic cell clearance	PMID:18768881^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097350	neutrophil clearance	PMID:18768881^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:18768881^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045063	T-helper 1 cell differentiation	PMID:15944249^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001200	positive regulation of dendritic cell differentiation	PMID:15944249^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	PMID:15944249^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	PMID:15944249^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002840	regulation of T cell mediated immune response to tumor cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63158	P		Seeded From UniProt	complete
involved_in	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	P		Seeded From UniProt	complete
involved_in	GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	PMID:22473704^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035711	T-helper 1 cell activation	PMID:22473704^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	PMID:22473704^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	PMID:22473704^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	PMID:17803946^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:17803946^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032072	regulation of restriction endodeoxyribonuclease activity	PMID:17803946^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070182	DNA polymerase binding	PMID:17803946^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090026	positive regulation of monocyte chemotaxis	PMID:22370717^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019958	C-X-C chemokine binding	PMID:22370717^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:22370717^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:22370717^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:24971542^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:21660935^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:20819940^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990774	tumor necrosis factor secretion	PMID:12765338^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050716	positive regulation of interleukin-1 secretion	PMID:12765338^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	PMID:12765338^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:12765338^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:12765338^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032392	DNA geometric change	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9YH06	P		Seeded From UniProt	complete
enables	GO:0097100	supercoiled DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9YH06	F		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9YH06	F		Seeded From UniProt	complete
enables	GO:0000405	bubble DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9YH06	F		Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9YH06	F		Seeded From UniProt	complete
involved_in	GO:0002643	regulation of tolerance induction	PMID:18631454^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032425	positive regulation of mismatch repair	PMID:15014079^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:23146691^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	PMID:23148224^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000426	negative regulation of apoptotic cell clearance	PMID:20826760^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:19223331^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06400	F		Seeded From UniProt	complete
involved_in	GO:0051103	DNA ligation involved in DNA repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12682	P		Seeded From UniProt	complete
enables	GO:0050786	RAGE receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63159	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19223331^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[20]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[21]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	PMID:19223331^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	PMID:11748232^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:19800306^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:19800306^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	F		Seeded From UniProt	complete
involved_in	GO:0033151	V(D)J recombination	PMID:9166431^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63159	P		Seeded From UniProt	complete
involved_in	GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly	PMID:8006019^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	PMID:19158276^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19841752^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000576)	Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:19223331^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19223331^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25208	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:11748232^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	P		Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19223331^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8339930^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19841752^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000576)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63159	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:19223331^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	F		Seeded From UniProt	complete
involved_in	GO:0002437	inflammatory response to antigenic stimulus	PMID:19841752^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002407	dendritic cell chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	P		Seeded From UniProt	complete
involved_in	GO:0001773	myeloid dendritic cell activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10103	P		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:12925773^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19158276^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:P01375)	Seeded From UniProt	complete
involved_in	GO:1902741	positive regulation of interferon-alpha secretion	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002672476 UniProtKB:P10103	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 UniProtKB:P12682	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 UniProtKB:P09429	P		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 UniProtKB:P10103	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476	P		Seeded From UniProt	complete
involved_in	GO:0050716	positive regulation of interleukin-1 secretion	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 UniProtKB:P09429	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P26583 WB:WBGene00001972	P		Seeded From UniProt	complete
involved_in	GO:0045089	positive regulation of innate immune response	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682	P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 RGD:2802	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 RGD:2802 UniProtKB:P09429	P		Seeded From UniProt	complete
involved_in	GO:0032502	developmental process	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 RGD:2802 UniProtKB:P09429 UniProtKB:P10103 ZFIN:ZDB-GENE-030131-341	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002672476 RGD:2802	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 PANTHER:PTN002672476 RGD:2802 UniProtKB:P10103	P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004362 FB:FBgn0278608 PANTHER:PTN000345179 RGD:2802 SGD:S000002157 SGD:S000004676 SGD:S000006256 UniProtKB:F1RJ01 UniProtKB:F2Z594 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682 UniProtKB:P17741 UniProtKB:P26583 UniProtKB:P26584 UniProtKB:P40618 UniProtKB:P40673 UniProtKB:Q32L31 UniProtKB:Q8I616 UniProtKB:Q8IB14 UniProtKB:Q9YH06	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0278608 MGI:MGI:96157 PANTHER:PTN000345179 RGD:2802 UniProtKB:P09429	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0278608 MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN000346026 UniProtKB:P09429 UniProtKB:P26583 WB:WBGene00001972	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000345179 SGD:S000002157 SGD:S000006256	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P40673 UniProtKB:Q32L31	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 RGD:2802 UniProtKB:P26583	C		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002672476 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682	P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96157 PANTHER:PTN000346026 SGD:S000002160 UniProtKB:F1RJ01 UniProtKB:F2Z594 UniProtKB:P12682 UniProtKB:P17741	C		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017967	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017967	C		Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	Reactome:R-HSA-168249	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006309	apoptotic DNA fragmentation	Reactome:R-HSA-140342	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6805981 Reactome:R-HSA-266204	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-997411 Reactome:R-HSA-879411 Reactome:R-HSA-6805981 Reactome:R-HSA-6804100 Reactome:R-HSA-6804099 Reactome:R-HSA-6800434 Reactome:R-HSA-6798748 Reactome:R-HSA-5432825	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	Reactome:R-HSA-168898	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0098	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bauer, EM et al. (2013) High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s). J. Biol. Chem. 288 1365-73 PubMed GONUTS page
↑ ^2.0 ^2.1 Lee, W et al. (2013) Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo. Food Chem. Toxicol. 52 97-104 PubMed GONUTS page
↑ Li, Y et al. (2013) A possible role of HMGB1 in DNA demethylation in CD4+ T cells from patients with systemic lupus erythematosus. Clin. Dev. Immunol. 2013 206298 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Shirasuna, K et al. (2016) AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration. Am. J. Reprod. Immunol. 75 557-68 PubMed GONUTS page
↑ ^5.0 ^5.1 Khoo, CP et al. (2017) miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration. Sci Rep 7 44137 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 El Gazzar, M et al. (2009) Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol. Cell. Biol. 29 1959-71 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Friggeri, A et al. (2010) HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin. Am. J. Physiol., Cell Physiol. 299 C1267-76 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Liu, G et al. (2008) High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. J. Immunol. 181 4240-6 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Dumitriu, IE et al. (2005) Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. J. Immunol. 174 7506-15 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Wild, CA et al. (2012) HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells. Int. Immunol. 24 485-94 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Prasad, R et al. (2007) HMGB1 is a cofactor in mammalian base excision repair. Mol. Cell 27 829-41 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Schiraldi, M et al. (2012) HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J. Exp. Med. 209 551-63 PubMed GONUTS page
↑ Liu, L et al. (2014) HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE. Biochem. Biophys. Res. Commun. 450 851-6 PubMed GONUTS page
↑ Youn, JH et al. (2011) Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model. Eur. J. Immunol. 41 2753-62 PubMed GONUTS page
↑ Tang, D et al. (2010) Endogenous HMGB1 regulates autophagy. J. Cell Biol. 190 881-92 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Li, J et al. () Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol. Med. 9 37-45 PubMed GONUTS page
↑ Kazama, H et al. (2008) Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 29 21-32 PubMed GONUTS page
↑ Yuan, F et al. (2004) Evidence for involvement of HMGB1 protein in human DNA mismatch repair. J. Biol. Chem. 279 20935-40 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 Stros, M et al. (2009) HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha. Nucleic Acids Res. 37 2070-86 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^22.0 ^22.1 Stros, M et al. (2002) HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. J. Biol. Chem. 277 7157-64 PubMed GONUTS page
↑ ^23.0 ^23.1 Zhu, XM et al. (2009) Effect of high mobility group box-1 protein on apoptosis of peritoneal macrophages. Arch. Biochem. Biophys. 492 54-61 PubMed GONUTS page
↑ Sawchuk, DJ et al. (1997) V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins. J. Exp. Med. 185 2025-32 PubMed GONUTS page
↑ Ge, H & Roeder, RG (1994) The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein. J. Biol. Chem. 269 17136-40 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Kalyan, S & Chow, AW (2009) Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion. Mediators Inflamm. 2009 819408 PubMed GONUTS page
↑ Paull, TT et al. (1993) The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures. Genes Dev. 7 1521-34 PubMed GONUTS page
↑ Pallier, C et al. (2003) Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes. Mol. Biol. Cell 14 3414-26 PubMed GONUTS page
↑ ^29.00 ^29.01 ^29.02 ^29.03 ^29.04 ^29.05 ^29.06 ^29.07 ^29.08 ^29.09 ^29.10 ^29.11 ^29.12 ^29.13 ^29.14 ^29.15 ^29.16 ^29.17 ^29.18 ^29.19 ^29.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23148224-1] 1.0 ^1.1 Bauer, EM et al. (2013) High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s). J. Biol. Chem. 288 1365-73 PubMed GONUTS page

[PMID:23146691-2] 2.0 ^2.1 Lee, W et al. (2013) Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo. Food Chem. Toxicol. 52 97-104 PubMed GONUTS page

[PMID:24082908-3] Li, Y et al. (2013) A possible role of HMGB1 in DNA demethylation in CD4+ T cells from patients with systemic lupus erythematosus. Clin. Dev. Immunol. 2013 206298 PubMed GONUTS page

[PMID:26961863-4] 4.0 ^4.1 ^4.2 Shirasuna, K et al. (2016) AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration. Am. J. Reprod. Immunol. 75 557-68 PubMed GONUTS page

[PMID:28276476-5] 5.0 ^5.1 Khoo, CP et al. (2017) miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration. Sci Rep 7 44137 PubMed GONUTS page

[PMID:19158276-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 El Gazzar, M et al. (2009) Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol. Cell. Biol. 29 1959-71 PubMed GONUTS page

[PMID:20826760-7] 7.0 ^7.1 ^7.2 Friggeri, A et al. (2010) HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin. Am. J. Physiol., Cell Physiol. 299 C1267-76 PubMed GONUTS page

[PMID:18768881-8] 8.0 ^8.1 ^8.2 Liu, G et al. (2008) High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. J. Immunol. 181 4240-6 PubMed GONUTS page

[PMID:15944249-9] 9.0 ^9.1 ^9.2 ^9.3 Dumitriu, IE et al. (2005) Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. J. Immunol. 174 7506-15 PubMed GONUTS page

[PMID:22473704-10] 10.0 ^10.1 ^10.2 ^10.3 Wild, CA et al. (2012) HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells. Int. Immunol. 24 485-94 PubMed GONUTS page

[PMID:17803946-11] 11.0 ^11.1 ^11.2 ^11.3 Prasad, R et al. (2007) HMGB1 is a cofactor in mammalian base excision repair. Mol. Cell 27 829-41 PubMed GONUTS page

[PMID:22370717-12] 12.0 ^12.1 ^12.2 ^12.3 Schiraldi, M et al. (2012) HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J. Exp. Med. 209 551-63 PubMed GONUTS page

[PMID:24971542-13] Liu, L et al. (2014) HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE. Biochem. Biophys. Res. Commun. 450 851-6 PubMed GONUTS page

[PMID:21660935-14] Youn, JH et al. (2011) Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model. Eur. J. Immunol. 41 2753-62 PubMed GONUTS page

[PMID:20819940-15] Tang, D et al. (2010) Endogenous HMGB1 regulates autophagy. J. Cell Biol. 190 881-92 PubMed GONUTS page

[PMID:12765338-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Li, J et al. () Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol. Med. 9 37-45 PubMed GONUTS page

[PMID:18631454-17] Kazama, H et al. (2008) Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 29 21-32 PubMed GONUTS page

[PMID:15014079-18] Yuan, F et al. (2004) Evidence for involvement of HMGB1 protein in human DNA mismatch repair. J. Biol. Chem. 279 20935-40 PubMed GONUTS page

[PMID:19223331-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 Stros, M et al. (2009) HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha. Nucleic Acids Res. 37 2070-86 PubMed GONUTS page

[PMID:22681889-20] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-21] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:11748232-22] 22.0 ^22.1 Stros, M et al. (2002) HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. J. Biol. Chem. 277 7157-64 PubMed GONUTS page

[PMID:19800306-23] 23.0 ^23.1 Zhu, XM et al. (2009) Effect of high mobility group box-1 protein on apoptosis of peritoneal macrophages. Arch. Biochem. Biophys. 492 54-61 PubMed GONUTS page

[PMID:9166431-24] Sawchuk, DJ et al. (1997) V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins. J. Exp. Med. 185 2025-32 PubMed GONUTS page

[PMID:8006019-25] Ge, H & Roeder, RG (1994) The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein. J. Biol. Chem. 269 17136-40 PubMed GONUTS page

[PMID:19841752-26] 26.0 ^26.1 ^26.2 Kalyan, S & Chow, AW (2009) Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion. Mediators Inflamm. 2009 819408 PubMed GONUTS page

[PMID:8339930-27] Paull, TT et al. (1993) The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures. Genes Dev. 7 1521-34 PubMed GONUTS page

[PMID:12925773-28] Pallier, C et al. (2003) Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes. Mol. Biol. Cell 14 3414-26 PubMed GONUTS page

[PMID:21873635-29] 29.00 ^29.01 ^29.02 ^29.03 ^29.04 ^29.05 ^29.06 ^29.07 ^29.08 ^29.09 ^29.10 ^29.11 ^29.12 ^29.13 ^29.14 ^29.15 ^29.16 ^29.17 ^29.18 ^29.19 ^29.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:HMGB1

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