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PMID:26961863
| Citation |
Shirasuna, K, Seno, K, Ohtsu, A, Shiratsuki, S, Ohkuchi, A, Suzuki, H, Matsubara, S, Nagayama, S, Iwata, H and Kuwayama, T (2016) AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration. Am. J. Reprod. Immunol. 75:557-68 |
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| Abstract |
Advanced glycation end products (AGEs) and high-mobility group box-1 (HMGB1) are considered contributing to placental inflammation. We examined the effect of AGEs and HMGB1 on cytokines from Sw.71 human trophoblast cell lines and the interactions between Sw.71 cells and THP-1-monocytes. |
| Links |
PubMed Online version:10.1111/aji.12506 |
| Keywords |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:2000778: positive regulation of interleukin-6 secretion |
ECO:0000315: |
P |
Figure 3 c shows increased secretions when NF-κB isn't inhibited (vs when it is, hence the IMP) |
complete | ||||
| GO:0032755: positive regulation of interleukin-6 production |
ECO:0000314: |
P |
Figure 1b |
complete | ||||
| GO:0032757: positive regulation of interleukin-8 production |
ECO:0000314: |
P |
Figure 5b shows increased Interleukin-8 secretion when HMGB1 is added. |
complete | ||||
| GO:2000343: positive regulation of chemokine (C-X-C motif) ligand 2 production |
ECO:0000314: |
P |
Figure 5a |
complete | ||||
Notes
See also
References
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