HUMAN:TLR4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TLR4
Protein Name(s)	Toll-like receptor 4 hToll
External Links
UniProt	O00206
EMBL	U93091 AB445638 DQ018107 DQ018108 DQ018109 AK290053 AK293068 AK303730 AL160272 AL160272 CH471090 CH471090 BC117422 EF535831 EF535832 EF535833 AF177765 AF177766 AF172171 AF172169 AF172170 U88880
CCDS	CCDS6818.1
RefSeq	NP_003257.1 NP_612564.1 NP_612567.1
UniGene	Hs.174312
PDB	2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A
PDBsum	2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A
ProteinModelPortal	O00206
SMR	O00206
BioGrid	112954
DIP	DIP-34769N
IntAct	O00206
MINT	MINT-3981856
BindingDB	O00206
ChEMBL	CHEMBL3038512
DrugBank	DB01183
GuidetoPHARMACOLOGY	1754
PhosphoSite	O00206
PaxDb	O00206
PRIDE	O00206
Ensembl	ENST00000355622 ENST00000394487
GeneID	7099
KEGG	hsa:7099
UCSC	uc004bjz.4
CTD	7099
GeneCards	GC09P120466
HGNC	HGNC:11850
HPA	CAB004025
MIM	603030 611488
neXtProt	NX_O00206
Orphanet	117
PharmGKB	PA36552
eggNOG	NOG249751
GeneTree	ENSGT00760000119006
HOVERGEN	HBG018823
InParanoid	O00206
KO	K10160
OMA	PESWDPC
OrthoDB	EOG7ZKS9G
PhylomeDB	O00206
TreeFam	TF351113
Reactome	REACT_150361 REACT_25148 REACT_25351 REACT_25374 REACT_6788 REACT_6894
SignaLink	O00206
EvolutionaryTrace	O00206
GeneWiki	TLR_4
GenomeRNAi	7099
NextBio	27773
PRO	PR:O00206
Proteomes	UP000005640
Bgee	O00206
ExpressionAtlas	O00206
Genevestigator	O00206
GO	GO:0005737 GO:0010008 GO:0009897 GO:0005887 GO:0046696 GO:0048471 GO:0005886 GO:0001530 GO:0001875 GO:0004872 GO:0004888 GO:0000187 GO:0002322 GO:0071222 GO:0071223 GO:0071260 GO:0042742 GO:0050829 GO:0016046 GO:0032497 GO:0007249 GO:0007252 GO:0006955 GO:0045087 GO:0032609 GO:0060729 GO:0031663 GO:0042116 GO:0002755 GO:0002756 GO:0070373 GO:0032689 GO:0032700 GO:0032707 GO:0032715 GO:0045671 GO:0032720 GO:0002537 GO:0030890 GO:0032722 GO:0070374 GO:0050729 GO:0032727 GO:0045359 GO:0032728 GO:0032729 GO:0032732 GO:0032733 GO:0045084 GO:0032735 GO:0032755 GO:0045416 GO:0032757 GO:0046330 GO:0060907 GO:0045348 GO:0042346 GO:0051092 GO:0045429 GO:0051770 GO:0070430 GO:0070434 GO:0010572 GO:0045944 GO:0042535 GO:0032760 GO:0050707 GO:0032496 GO:0042088 GO:0034134 GO:0034138 GO:0034142 GO:0002224 GO:0038123 GO:0038124 GO:0035666
Gene3D	3.40.50.10140
InterPro	IPR000483 IPR001611 IPR025875 IPR003591 IPR000157 IPR027168 IPR017241
PANTHER	PTHR24365:SF230
Pfam	PF12799 PF13855 PF01582
PIRSF	PIRSF037595
SMART	SM00369 SM00082 SM00255
SUPFAM	SSF52200
PROSITE	PS51450 PS50104

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24585880^[1]	ECO:0000314			P		Figure 3 C stimulated with LPS show that when TLR4 is activated there is an increase of tyrosine receptor kinase A expression of mRNA (TrkA). This is further translated as indicated by the westerblot for TrkA in figure 3E.	complete CACAO 9646
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	occurs_in:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	C	part_of:(CL:0000129) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:26370079^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:20037584^[3]	ECO:0000305	curator inference used in manual assertion	GO:1904646	F		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:30883606^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	PMID:30883606^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	PMID:11672593^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	PMID:11672593^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404)	Seeded From UniProt	complete
involved_in	GO:1903223	positive regulation of oxidative stress-induced neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000540) occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:1900017	positive regulation of cytokine production involved in inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	occurs_in:(CL:0000235) part_of:(GO:1900017)	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	part_of:(GO:1904646) regulates_o_occurs_in:(CL:0000129) positively_regulates:(GO:0070997)	Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSG00000125538)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSG00000271503)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSG00000125538) part_of:(GO:1904646)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSG00000163739)\|regulates_o_occurs_in(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSG00000081041)\|regulates_o_occurs_in(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSG00000271503)	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404)	Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P	part_of:(GO:0050729)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20037584^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y2C9	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16338228^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20037584^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16671,UniProtKB:Q9Y2C9	C	part_of:(CL:0000576) coincident_with:(CHEBI:64647) exists_during:(GO:0006897)\|part_of(CL:0000576) coincident_with:(CHEBI:60151) exists_during:(GO:0006897)	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P16671,UniProtKB:Q9Y2C9	P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404)	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:11432859^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:11432859^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:20037584^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16671,UniProtKB:Q9Y2C9	C	part_of:(CL:0000576) coincident_with:(CHEBI:64647) part_of:(GO:0005622)\|part_of:(CL:0000576) coincident_with:(CHEBI:60151) part_of:(GO:0005622)	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:20037584^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16671,UniProtKB:Q9Y2C9	F	occurs_in:(CL:0000576) part_of:(GO:1904646)\|occurs_in(CL:0000576) part_of:(GO:0071404)	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P16671,UniProtKB:Q9Y2C9	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092,UniProtKB:P16671,UniProtKB:Q9Y2C9	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23817958^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134) has_regulation_target:(UniProtKB:O00182)	Seeded From UniProt	complete
involved_in	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:25204797^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002618)	Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	PMID:11274165^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0046696	lipopolysaccharide receptor complex	PMID:11274165^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0060729	intestinal epithelial structure maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:16514062^[11]	ECO:0000305	curator inference used in manual assertion	GO:0001530	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:19740627^[12]	ECO:0000305	curator inference used in manual assertion	GO:1901224	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032732	positive regulation of interleukin-1 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032727	positive regulation of interferon-alpha production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032707	negative regulation of interleukin-23 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:16514062^[11]	ECO:0000305	curator inference used in manual assertion	GO:0001530	P		Seeded From UniProt	complete
involved_in	GO:0010572	positive regulation of platelet activation	PMID:16514062^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16514062^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:16514062^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUK6	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:15027902^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000451)	Seeded From UniProt	complete
part_of	GO:0046696	lipopolysaccharide receptor complex	PMID:19252480^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045671	negative regulation of osteoclast differentiation	PMID:12133979^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045416	positive regulation of interleukin-8 biosynthetic process	PMID:17951129^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045084	positive regulation of interleukin-12 biosynthetic process	PMID:15027902^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	PMID:17951129^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042116	macrophage activation	PMID:10835634^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042088	T-helper 1 type immune response	PMID:11970998^[19]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032497	detection of lipopolysaccharide	PMID:19252480^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016046	detection of fungus	PMID:11254600^[20]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15027902^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000576)	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:11970998^[19]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001875	lipopolysaccharide receptor activity	PMID:19252480^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:10835634^[18]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96824 PANTHER:PTN000687406	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 UniProtKB:O00206	C		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138 RGD:735171	P		Seeded From UniProt	complete
enables	GO:0001875	lipopolysaccharide receptor activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687407 UniProtKB:O00206	F		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687407 RGD:3870 UniProtKB:O00206	F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12594207^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:12594207^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:10880523^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Y6Y9	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:10880523^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O95711	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:10880523^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23155421^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00206	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23059983^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00206	F		Seeded From UniProt	complete
involved_in	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:1903223	positive regulation of oxidative stress-induced neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:1900017	positive regulation of cytokine production involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0071223	cellular response to lipoteichoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0070430	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0060907	positive regulation of macrophage cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0060729	intestinal epithelial structure maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0050671	positive regulation of lymphocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0045359	positive regulation of interferon-beta biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032874	positive regulation of stress-activated MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032732	positive regulation of interleukin-1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032727	positive regulation of interferon-alpha production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032707	negative regulation of interleukin-23 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032609	interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0014002	astrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0010572	positive regulation of platelet activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	C		Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0002730	regulation of dendritic cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0002537	nitric oxide production involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0002322	B cell proliferation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUK6 ensembl:ENSMUSP00000045770	P		Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000157	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	C		Seeded From UniProt	complete
involved_in	GO:0034142	toll-like receptor 4 signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
involved_in	GO:0042116	macrophage activation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
part_of	GO:0046696	lipopolysaccharide receptor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	C		Seeded From UniProt	complete
involved_in	GO:0050707	regulation of cytokine secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:10426995^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:10426995^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:15356140^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:10426995^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	Reactome:R-HSA-2562564	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	Reactome:R-HSA-2569057	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Reactome:R-HSA-937061 Reactome:R-HSA-936964	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034142	toll-like receptor 4 signaling pathway	Reactome:R-HSA-166016	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034128	negative regulation of MyD88-independent toll-like receptor signaling pathway	Reactome:R-HSA-2559568	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	Reactome:R-HSA-937075 Reactome:R-HSA-937029 Reactome:R-HSA-936985 Reactome:R-HSA-936952 Reactome:R-HSA-936951 Reactome:R-HSA-936947 Reactome:R-HSA-936941 Reactome:R-HSA-5362500 Reactome:R-HSA-5362486 Reactome:R-HSA-450358 Reactome:R-HSA-2569057 Reactome:R-HSA-2562564 Reactome:R-HSA-2562541 Reactome:R-HSA-2559568 Reactome:R-HSA-2213017 Reactome:R-HSA-2201338 Reactome:R-HSA-2201293 Reactome:R-HSA-168921 Reactome:R-HSA-168915 Reactome:R-HSA-166271 Reactome:R-HSA-166245 Reactome:R-HSA-166175 Reactome:R-HSA-166168	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Reactome:R-HSA-937072	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-937079 Reactome:R-HSA-937059 Reactome:R-HSA-937022 Reactome:R-HSA-8870678 Reactome:R-HSA-8869667 Reactome:R-HSA-6805943 Reactome:R-HSA-5602672 Reactome:R-HSA-5602606 Reactome:R-HSA-5602383 Reactome:R-HSA-5602353 Reactome:R-HSA-5432852 Reactome:R-HSA-5432849 Reactome:R-HSA-5432825 Reactome:R-HSA-2559414 Reactome:R-HSA-2262777 Reactome:R-HSA-2262775 Reactome:R-HSA-2201322 Reactome:R-HSA-2201316 Reactome:R-HSA-2201293 Reactome:R-HSA-166363 Reactome:R-HSA-166362 Reactome:R-HSA-166286 Reactome:R-HSA-166284 Reactome:R-HSA-166119 Reactome:R-HSA-166091 Reactome:R-HSA-166082 Reactome:R-HSA-166072 Reactome:R-HSA-166041	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:R-HSA-166166	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:R-HSA-166058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	Reactome:R-HSA-168898	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Prencipe, G et al. (2014) Nerve growth factor downregulates inflammatory response in human monocytes through TrkA. J. Immunol. 192 3345-54 PubMed GONUTS page
↑ Okla, M et al. (2015) Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. J. Biol. Chem. 290 26476-90 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Stewart, CR et al. (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat. Immunol. 11 155-61 PubMed GONUTS page
↑ ^4.0 ^4.1 Skjesol, A et al. (2019) The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. PLoS Pathog. 15 e1007684 PubMed GONUTS page
↑ ^5.0 ^5.1 Mita, Y et al. (2001) Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor. Immunol. Lett. 78 97-101 PubMed GONUTS page
↑ Konno, K et al. (2006) A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. Biochem. Biophys. Res. Commun. 339 1076-82 PubMed GONUTS page
↑ ^7.0 ^7.1 Lee, SH et al. (2001) Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. J. Biol. Chem. 276 34495-500 PubMed GONUTS page
↑ Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page
↑ Fork, C et al. (2014) Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res. Cardiol. 109 439 PubMed GONUTS page
↑ ^10.0 ^10.1 da Silva Correia, J et al. (2001) Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 276 21129-35 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Ståhl, AL et al. (2006) Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. Blood 108 167-76 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Yu, N et al. (2009) Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J. Dermatol. Sci. 56 113-20 PubMed GONUTS page
↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Uronen-Hansson, H et al. (2004) Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria. Immunology 111 173-8 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Park, BS et al. (2009) The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458 1191-5 PubMed GONUTS page
↑ Takami, M et al. (2002) Stimulation by toll-like receptors inhibits osteoclast differentiation. J. Immunol. 169 1516-23 PubMed GONUTS page
↑ ^17.0 ^17.1 Begon, E et al. () Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin. Eur J Dermatol 17 497-506 PubMed GONUTS page
↑ ^18.0 ^18.1 Arbour, NC et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25 187-91 PubMed GONUTS page
↑ ^19.0 ^19.1 Dabbagh, K et al. (2002) Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J. Immunol. 168 4524-30 PubMed GONUTS page
↑ Wang, JE et al. (2001) Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect. Immun. 69 2402-6 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^22.0 ^22.1 Schröder, NW et al. (2003) Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J. Biol. Chem. 278 15587-94 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Ogata, H et al. (2000) The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192 23-9 PubMed GONUTS page
↑ Godfroy, JI 3rd et al. (2012) Isolated Toll-like receptor transmembrane domains are capable of oligomerization. PLoS ONE 7 e48875 PubMed GONUTS page
↑ Raghavan, B et al. (2012) Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2. EMBO Rep. 13 1109-15 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Brightbill, HD et al. (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285 732-6 PubMed GONUTS page
↑ Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page

[PMID:24585880-1] Prencipe, G et al. (2014) Nerve growth factor downregulates inflammatory response in human monocytes through TrkA. J. Immunol. 192 3345-54 PubMed GONUTS page

[PMID:26370079-2] Okla, M et al. (2015) Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. J. Biol. Chem. 290 26476-90 PubMed GONUTS page

[PMID:20037584-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Stewart, CR et al. (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat. Immunol. 11 155-61 PubMed GONUTS page

[PMID:30883606-4] 4.0 ^4.1 Skjesol, A et al. (2019) The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. PLoS Pathog. 15 e1007684 PubMed GONUTS page

[PMID:11672593-5] 5.0 ^5.1 Mita, Y et al. (2001) Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor. Immunol. Lett. 78 97-101 PubMed GONUTS page

[PMID:16338228-6] Konno, K et al. (2006) A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. Biochem. Biophys. Res. Commun. 339 1076-82 PubMed GONUTS page

[PMID:11432859-7] 7.0 ^7.1 Lee, SH et al. (2001) Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. J. Biol. Chem. 276 34495-500 PubMed GONUTS page

[PMID:23817958-8] Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page

[PMID:25204797-9] Fork, C et al. (2014) Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res. Cardiol. 109 439 PubMed GONUTS page

[PMID:11274165-10] 10.0 ^10.1 da Silva Correia, J et al. (2001) Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 276 21129-35 PubMed GONUTS page

[PMID:16514062-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Ståhl, AL et al. (2006) Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. Blood 108 167-76 PubMed GONUTS page

[PMID:19740627-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Yu, N et al. (2009) Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J. Dermatol. Sci. 56 113-20 PubMed GONUTS page

[PMID:19593445-13] Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page

[PMID:15027902-14] 14.0 ^14.1 ^14.2 Uronen-Hansson, H et al. (2004) Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria. Immunology 111 173-8 PubMed GONUTS page

[PMID:19252480-15] 15.0 ^15.1 ^15.2 Park, BS et al. (2009) The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458 1191-5 PubMed GONUTS page

[PMID:12133979-16] Takami, M et al. (2002) Stimulation by toll-like receptors inhibits osteoclast differentiation. J. Immunol. 169 1516-23 PubMed GONUTS page

[PMID:17951129-17] 17.0 ^17.1 Begon, E et al. () Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin. Eur J Dermatol 17 497-506 PubMed GONUTS page

[PMID:10835634-18] 18.0 ^18.1 Arbour, NC et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25 187-91 PubMed GONUTS page

[PMID:11970998-19] 19.0 ^19.1 Dabbagh, K et al. (2002) Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J. Immunol. 168 4524-30 PubMed GONUTS page

[PMID:11254600-20] Wang, JE et al. (2001) Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect. Immun. 69 2402-6 PubMed GONUTS page

[PMID:21873635-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12594207-22] 22.0 ^22.1 Schröder, NW et al. (2003) Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J. Biol. Chem. 278 15587-94 PubMed GONUTS page

[PMID:10880523-23] 23.0 ^23.1 ^23.2 Ogata, H et al. (2000) The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192 23-9 PubMed GONUTS page

[PMID:23155421-24] Godfroy, JI 3rd et al. (2012) Isolated Toll-like receptor transmembrane domains are capable of oligomerization. PLoS ONE 7 e48875 PubMed GONUTS page

[PMID:23059983-25] Raghavan, B et al. (2012) Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2. EMBO Rep. 13 1109-15 PubMed GONUTS page

[PMID:10426995-26] 26.0 ^26.1 ^26.2 Brightbill, HD et al. (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285 732-6 PubMed GONUTS page

[PMID:15356140-27] Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page

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HUMAN:TLR4

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