HUMAN:FIBB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FGB
Protein Name(s)	Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain
External Links
UniProt	P02675
EMBL	J00129 J00131 J00130 J00132 J00133 M64983 AF388026 AK312972 CH471056 BC007030 BC106760 BC107766 AH002694 X05018
CCDS	CCDS3786.1
PIR	B43568
RefSeq	NP_001171670.1 NP_005132.2
UniGene	Hs.300774
PDB	1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3BVH 3E1I 3GHG 3H32 3HUS
PDBsum	1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3BVH 3E1I 3GHG 3H32 3HUS
ProteinModelPortal	P02675
SMR	P02675
BioGrid	108535
DIP	DIP-385N
IntAct	P02675
STRING	9606.ENSP00000306099
BindingDB	P02675
ChEMBL	CHEMBL2364709
DrugBank	DB00364
PhosphoSite	P02675
DMDM	399492
DOSAC-COBS-2DPAGE	P02675
OGP	P02675
REPRODUCTION-2DPAGE	IPI00298497 P02675
SWISS-2DPAGE	P02675
UCD-2DPAGE	P02675
MaxQB	P02675
PaxDb	P02675
PeptideAtlas	P02675
PRIDE	P02675
Ensembl	ENST00000302068
GeneID	2244
KEGG	hsa:2244
UCSC	uc003ioa.4
CTD	2244
GeneCards	GC04P155484
HGNC	HGNC:3662
HPA	CAB008624 HPA001900 HPA001901
MIM	134830 202400
neXtProt	NX_P02675
Orphanet	98880 98881 248408 101041
PharmGKB	PA163
eggNOG	NOG277105
HOGENOM	HOG000059561
HOVERGEN	HBG005707
InParanoid	P02675
KO	K03904
OMA	TIHNGMF
OrthoDB	EOG7X9G60
PhylomeDB	P02675
TreeFam	TF336658
Reactome	REACT_13552 REACT_1439 REACT_15381 REACT_15523
ChiTaRS	FGB
EvolutionaryTrace	P02675
GeneWiki	Fibrinogen_beta_chain
GenomeRNAi	2244
NextBio	35459926
PMAP-CutDB	P02675
PRO	PR:P02675
Proteomes	UP000005640
Bgee	P02675
CleanEx	HS_FGB
ExpressionAtlas	P02675
Genevestigator	P02675
GO	GO:0072562 GO:0005938 GO:0009986 GO:0009897 GO:0005576 GO:0005615 GO:0070062 GO:0005577 GO:0005886 GO:0031091 GO:0031093 GO:0031982 GO:0051087 GO:0005198 GO:0007596 GO:0007160 GO:0043623 GO:0071347 GO:0044320 GO:0030198 GO:0045087 GO:2000352 GO:1902042 GO:0030168 GO:0070527 GO:0002576 GO:0070374 GO:0045921 GO:0034116 GO:0090277 GO:0050714 GO:1900026 GO:0045907 GO:0051258 GO:0051592 GO:0007165
Gene3D	3.90.215.10 4.10.530.10
InterPro	IPR014716 IPR014715 IPR002181 IPR012290 IPR020837
Pfam	PF08702 PF00147
SMART	SM00186
SUPFAM	SSF56496
PROSITE	PS00514 PS51406

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043152	induction of bacterial agglutination	PMID:24367264^[1]	ECO:0000314			P		Figure 2. Fg induced agglutination in all of wild type strains of S. aureus	complete CACAO 10016
enables	GO:0005201	extracellular matrix structural constituent	PMID:25037231^[2]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0001155)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:28327460^[3]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(CL:0002540)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002540)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28344315^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002371)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:28344315^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0002371)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)\|part_of:(UBERON:0001911)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:28675934^[5]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0003688)\|occurs_in:(UBERON:0001911)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:25037231^[2]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0072378	blood coagulation, fibrin clot formation	PMID:16846481^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042730	fibrinolysis	PMID:16846481^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031639	plasminogen activation	PMID:16846481^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005577	fibrinogen complex	PMID:16846481^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005577	fibrinogen complex	PMID:18676163^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043152	induction of bacterial agglutination	PMID:24367264^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:24769233^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)	Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	PMID:10903502^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:10903502^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0090277	positive regulation of peptide hormone secretion	PMID:19193866^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05305) occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0070527	platelet aggregation	PMID:6281794^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:10903502^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:19193866^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051258	protein polymerization	PMID:12706644^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0050839	cell adhesion molecule binding	PMID:9182580^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	PMID:19193866^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P04275) occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0045921	positive regulation of exocytosis	PMID:19193866^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	PMID:15739255^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001980) occurs_in:(UBERON:0008488)\|occurs_in:(UBERON:0000947)\|occurs_in:(UBERON:0002060)	Seeded From UniProt	complete
involved_in	GO:0034622	cellular protein-containing complex assembly	PMID:8910396^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P02671) has_direct_input:(UniProtKB:P02675) has_direct_input:(UniProtKB:P02679)	Seeded From UniProt	complete
involved_in	GO:0034116	positive regulation of heterotypic cell-cell adhesion	PMID:8100742^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	PMID:10903502^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005577	fibrinogen complex	PMID:8910396^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	PMID:8910396^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0005102	signaling receptor binding	PMID:10903502^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[18]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[19]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
part_of	GO:0005577	fibrinogen complex	PMID:6688356^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	PMID:24041635^[21]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:19996109^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10909	F		Seeded From UniProt	complete
part_of	GO:0031091	platelet alpha granule	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:6777381^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19996109^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14718574^[24]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14480 ensembl:ENSRNOP00000009813	C		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14480 ensembl:ENSRNOP00000009813	P		Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14480 ensembl:ENSRNOP00000009813	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14480 ensembl:ENSRNOP00000009813	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K0E8 ensembl:ENSMUSP00000039472	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K0E8 ensembl:ENSMUSP00000039472	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012290	F		Seeded From UniProt	complete
part_of	GO:0005577	fibrinogen complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012290	C		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037580	P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012290	P		Seeded From UniProt	complete
involved_in	GO:0051258	protein polymerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012290	P		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	Reactome:R-HSA-1474244	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-140875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-114560	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8870678 Reactome:R-HSA-481007 Reactome:R-HSA-429441 Reactome:R-HSA-429415 Reactome:R-HSA-377644 Reactome:R-HSA-377643 Reactome:R-HSA-377641 Reactome:R-HSA-377640 Reactome:R-HSA-372705 Reactome:R-HSA-372697 Reactome:R-HSA-372693 Reactome:R-HSA-354165 Reactome:R-HSA-354149 Reactome:R-HSA-354124 Reactome:R-HSA-354087 Reactome:R-HSA-354073 Reactome:R-HSA-354066 Reactome:R-HSA-216082 Reactome:R-HSA-216069 Reactome:R-HSA-140851 Reactome:R-HSA-140842 Reactome:R-HSA-140840 Reactome:R-HSA-114560	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	Reactome:R-HSA-168898	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0007599	hemostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0356	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0094	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Walker, JN et al. (2013) The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis. PLoS Pathog. 9 e1003819 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ ^3.0 ^3.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ ^4.0 ^4.1 Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
↑ ^5.0 ^5.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Flood, VH et al. (2006) The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance. Br. J. Haematol. 134 220-6 PubMed GONUTS page
↑ Platè, M et al. () Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion. Blood Cells Mol. Dis. 41 292-7 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Pluskota, E & D'Souza, SE (2000) Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival. Eur. J. Biochem. 267 4693-704 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Sen, U et al. (2009) Fibrinogen-induced endothelin-1 production from endothelial cells. Am. J. Physiol., Cell Physiol. 296 C840-7 PubMed GONUTS page
↑ Hawiger, J et al. (1982) gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors. Proc. Natl. Acad. Sci. U.S.A. 79 2068-71 PubMed GONUTS page
↑ Meyer, M et al. (2003) Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aalpha 9, Leu-->Pro). Thromb. Res. 109 145-51 PubMed GONUTS page
↑ Gardiner, EE & D'Souza, SE (1997) A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1. J. Biol. Chem. 272 15474-80 PubMed GONUTS page
↑ Lominadze, D et al. (2005) Fibrinogen and fragment D-induced vascular constriction. Am. J. Physiol. Heart Circ. Physiol. 288 H1257-64 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Huang, S et al. (1996) The role of betagamma and alphagamma complexes in the assembly of human fibrinogen. J. Biol. Chem. 271 27942-7 PubMed GONUTS page
↑ Languino, LR et al. (1993) Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway. Cell 73 1423-34 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ Chung, DW et al. (1983) Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen. Biochemistry 22 3244-50 PubMed GONUTS page
↑ Snir, A et al. (2013) The role of fibrin matrices and tissue factor in early-term trophoblast proliferation and spreading. Thromb. Res. 132 477-83 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Phillips, DR et al. (1980) Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets. J. Biol. Chem. 255 11629-32 PubMed GONUTS page
↑ ^23.0 ^23.1 Wyatt, AR & Wilson, MR (2010) Identification of human plasma proteins as major clients for the extracellular chaperone clusterin. J. Biol. Chem. 285 3532-9 PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:24367264-1] 1.0 ^1.1 Walker, JN et al. (2013) The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis. PLoS Pathog. 9 e1003819 PubMed GONUTS page

[PMID:25037231-2] 2.0 ^2.1 ^2.2 ^2.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:28327460-3] 3.0 ^3.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:28344315-4] 4.0 ^4.1 Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page

[PMID:28675934-5] 5.0 ^5.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:16846481-6] 6.0 ^6.1 ^6.2 ^6.3 Flood, VH et al. (2006) The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance. Br. J. Haematol. 134 220-6 PubMed GONUTS page

[PMID:18676163-7] Platè, M et al. () Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion. Blood Cells Mol. Dis. 41 292-7 PubMed GONUTS page

[PMID:23533145-8] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:24769233-9] Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page

[PMID:10903502-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Pluskota, E & D'Souza, SE (2000) Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival. Eur. J. Biochem. 267 4693-704 PubMed GONUTS page

[PMID:19193866-11] 11.0 ^11.1 ^11.2 ^11.3 Sen, U et al. (2009) Fibrinogen-induced endothelin-1 production from endothelial cells. Am. J. Physiol., Cell Physiol. 296 C840-7 PubMed GONUTS page

[PMID:6281794-12] Hawiger, J et al. (1982) gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors. Proc. Natl. Acad. Sci. U.S.A. 79 2068-71 PubMed GONUTS page

[PMID:12706644-13] Meyer, M et al. (2003) Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aalpha 9, Leu-->Pro). Thromb. Res. 109 145-51 PubMed GONUTS page

[PMID:9182580-14] Gardiner, EE & D'Souza, SE (1997) A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1. J. Biol. Chem. 272 15474-80 PubMed GONUTS page

[PMID:15739255-15] Lominadze, D et al. (2005) Fibrinogen and fragment D-induced vascular constriction. Am. J. Physiol. Heart Circ. Physiol. 288 H1257-64 PubMed GONUTS page

[PMID:8910396-16] 16.0 ^16.1 ^16.2 Huang, S et al. (1996) The role of betagamma and alphagamma complexes in the assembly of human fibrinogen. J. Biol. Chem. 271 27942-7 PubMed GONUTS page

[PMID:8100742-17] Languino, LR et al. (1993) Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway. Cell 73 1423-34 PubMed GONUTS page

[PMID:22516433-18] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:16502470-19] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:6688356-20] Chung, DW et al. (1983) Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen. Biochemistry 22 3244-50 PubMed GONUTS page

[PMID:24041635-21] Snir, A et al. (2013) The role of fibrin matrices and tissue factor in early-term trophoblast proliferation and spreading. Thromb. Res. 132 477-83 PubMed GONUTS page

[PMID:6777381-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Phillips, DR et al. (1980) Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets. J. Biol. Chem. 255 11629-32 PubMed GONUTS page

[PMID:19996109-23] 23.0 ^23.1 Wyatt, AR & Wilson, MR (2010) Identification of human plasma proteins as major clients for the extracellular chaperone clusterin. J. Biol. Chem. 285 3532-9 PubMed GONUTS page

[PMID:14718574-24] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

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HUMAN:FIBB

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