MOUSE:TLR2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tlr2
Protein Name(s)	Toll-like receptor 2
External Links
UniProt	Q9QUN7
EMBL	AF185284 AF124741 AF216289 AF165189 AK005043 AK154504
CCDS	CCDS17435.1
RefSeq	NP_036035.3
UniGene	Mm.87596
PDB	2Z81 2Z82 3A79 3A7B 3A7C
PDBsum	2Z81 2Z82 3A79 3A7B 3A7C
ProteinModelPortal	Q9QUN7
SMR	Q9QUN7
IntAct	Q9QUN7
STRING	10090.ENSMUSP00000029623
ChEMBL	CHEMBL3137289
PhosphoSite	Q9QUN7
PRIDE	Q9QUN7
GeneID	24088
KEGG	mmu:24088
CTD	7097
MGI	MGI:1346060
eggNOG	NOG251801
HOGENOM	HOG000110611
HOVERGEN	HBG108574
InParanoid	Q9QUN7
KO	K10159
PhylomeDB	Q9QUN7
EvolutionaryTrace	Q9QUN7
NextBio	304101
PRO	PR:Q9QUN7
Proteomes	UP000000589
CleanEx	MM_TLR2
Genevestigator	Q9QUN7
GO	GO:0009897 GO:0016021 GO:0030670 GO:0005886 GO:0035354 GO:0035355 GO:0042498 GO:0070891 GO:0046982 GO:0004888 GO:0042497 GO:0002752 GO:0071221 GO:0071223 GO:0071224 GO:0042892 GO:0050830 GO:0052063 GO:0006954 GO:0045087 GO:0002755 GO:0044130 GO:0032695 GO:0032700 GO:0032722 GO:0050715 GO:0050729 GO:0032728 GO:0032735 GO:0032741 GO:0032755 GO:0002687 GO:0060907 GO:0045429 GO:0051770 GO:0045944 GO:0042535 GO:0032760 GO:0009617 GO:0002238 GO:0032494 GO:0034134
Gene3D	3.40.50.10140
InterPro	IPR000483 IPR001611 IPR003591 IPR000157 IPR027185 IPR017241
PANTHER	PTHR24365:SF17
Pfam	PF13504 PF13855 PF01582
PIRSF	PIRSF037595
SMART	SM00369 SM00082 SM00255
SUPFAM	SSF52200
PROSITE	PS51450 PS50104

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002218	activation of innate immune response	PMID:15501775^[1]	ECO:0000314			P		Figure 4(A) shows the results of a SuperArray blot. The assay shows that there is increased levels of mRNA for cytokines and cytokine receptors in the W/T mice treated with whole Helicobacter pylori as opposed to the control. 4(B and C) shows that TLR2 K/O mice do not produce IL-6 (a cytokine) in the presence of H. pylori, but do produce cytokine in the presence of E. coli. This suggests that TLR2 is the dominant toll-like receptor to activate the innate immune system in response to Helicobacter.	complete CACAO 9852
involved_in	GO:0030837	negative regulation of actin filament polymerization	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	part_of:(GO:1904646) regulates_o_occurs_in:(CL:0000235) causally_upstream_of:(GO:0006909)	Seeded From UniProt	complete
involved_in	GO:0050765	negative regulation of phagocytosis	PMID:22198949^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:1904646) regulates_o_occurs_in:(CL:0000235) has_regulation_target:(ComplexPortal:CPX-1134)	Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	part_of:(GO:1904646) regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:22198949^[2]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1134	F	occurs_in:(CL:0000129)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:22198949^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0000113) part_of:(GO:1904646) has_regulation_target:(UniProtKB:P01584)	Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0000113) part_of:(GO:1904646) has_regulation_target:(UniProtKB:P01375)	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0000113) part_of:(GO:1904646)	Seeded From UniProt	complete
involved_in	GO:0051964	negative regulation of synapse assembly	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P49768	P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P49768	P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0050765	negative regulation of phagocytosis	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P49768	P	occurs_in:(UBERON:0000956) has_regulation_target:(UniProtKB:P05067:PRO_0000000092)	Seeded From UniProt	complete
involved_in	GO:0032640	tumor necrosis factor production	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P49768	P	has_agent:(CL:0002092) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0014005	microglia development	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P49768	P	has_agent:(CL:0002092) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60603	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60603	C		Seeded From UniProt	complete
involved_in	GO:0071727	cellular response to triacyl bacterial lipopeptide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
involved_in	GO:0071726	cellular response to diacyl bacterial lipopeptide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	PMID:15356140^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15356140^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:15356140^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:15356140^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032741	positive regulation of interleukin-18 production	PMID:15356140^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	PMID:15356140^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:15356140^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687557 UniProtKB:O60603	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 UniProtKB:O00206	C		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138 RGD:735171	P		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687557 RGD:735138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904417	positive regulation of xenophagy	PMID:22033934^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P	occurs_in:(CL:0000235) regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:22033934^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P	occurs_in:(CL:0000235) regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071727	cellular response to triacyl bacterial lipopeptide	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071726	cellular response to diacyl bacterial lipopeptide	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
enables	GO:0071723	lipopeptide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071346	cellular response to interferon-gamma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071224	cellular response to peptidoglycan	PMID:16949315^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071223	cellular response to lipoteichoic acid	PMID:15690042^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071223	cellular response to lipoteichoic acid	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071221	cellular response to bacterial lipopeptide	PMID:15690042^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0070891	lipoteichoic acid binding	PMID:19931471^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070542	response to fatty acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:22033934^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P	regulates_o_occurs_in:(CL:0000235) occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060907	positive regulation of macrophage cytokine production	PMID:10549626^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0052063	induction by symbiont of defense-related host nitric oxide production	PMID:16239543^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P	has_participant:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:19139201^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:15690042^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:11067888^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050715	positive regulation of cytokine secretion	PMID:19770268^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2157947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:19931471^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9EPW9	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:17889651^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046209	nitric oxide metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:16239543^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P	regulates_o_occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:10549626^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P	regulates_o_occurs_in:(CL:0000581)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044130	negative regulation of growth of symbiont in host	PMID:15690042^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P	regulates_o_occurs_in:(EMAPA:25765)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044130	negative regulation of growth of symbiont in host	PMID:11067888^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P	regulates_o_occurs_in:(EMAPA:16332)\|regulates_o_occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	C		Seeded From UniProt	complete
enables	GO:0042834	peptidoglycan binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	PMID:16239543^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P	regulates_o_occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
enables	GO:0042498	diacyl lipopeptide binding	PMID:19931471^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042498	diacyl lipopeptide binding	PMID:17889651^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042497	triacyl lipopeptide binding	PMID:17889651^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042497	triacyl lipopeptide binding	PMID:17889651^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042496	detection of diacyl bacterial lipopeptide	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042495	detection of triacyl bacterial lipopeptide	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
part_of	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex	PMID:19931471^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9EPW9	C		Seeded From UniProt	complete
part_of	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	PMID:17889651^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	C		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034123	positive regulation of toll-like receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:16239543^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P	regulates_o_occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:15690042^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:12719478^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:11067888^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:10549626^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032757	positive regulation of interleukin-8 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:11067888^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:10549626^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:18261938^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032722	positive regulation of chemokine production	PMID:16239543^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P	regulates_o_occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032722	positive regulation of chemokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032700	negative regulation of interleukin-17 production	PMID:16239543^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P	regulates_o_occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032695	negative regulation of interleukin-12 production	PMID:16949315^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032613	interleukin-10 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032494	response to peptidoglycan	PMID:17114491^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032494	response to peptidoglycan	PMID:10549626^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032493	response to bacterial lipoprotein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032289	central nervous system myelin formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15220916^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:17114491^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P		Seeded From UniProt	complete
enables	GO:0008329	signaling pattern recognition receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007252	I-kappaB phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006952	defense response	PMID:12091878^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006691	leukotriene metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12719478^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	PMID:12719478^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108005	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002752	cell surface pattern recognition receptor signaling pathway	PMID:12719478^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002730	regulation of dendritic cell cytokine production	PMID:19047410^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002687	positive regulation of leukocyte migration	PMID:17114491^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674036	P	occurs_in:(EMAPA:16138) results_in_movement_of:(CL:0000738)\|occurs_in(EMAPA:16138) results_in_movement_of:(CL:0000775)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002374	cytokine secretion involved in immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002238	response to molecule of fungal origin	PMID:12719478^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178675	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002224	toll-like receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001775	cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001774	microglial cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735138	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000157	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	C		Seeded From UniProt	complete
involved_in	GO:0034134	toll-like receptor 2 signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0050707	regulation of cytokine secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0071221	cellular response to bacterial lipopeptide	PMID:15356140^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:15356140^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0030670	phagocytic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0205	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mandell, L et al. (2004) Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect. Immun. 72 6446-54 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Liu, S et al. (2012) TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. J. Immunol. 188 1098-107 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Anand, PK et al. (2011) TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J. Biol. Chem. 286 42981-91 PubMed GONUTS page
↑ ^6.0 ^6.1 Watanabe, T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25 473-85 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Hoebe, K et al. (2005) CD36 is a sensor of diacylglycerides. Nature 433 523-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Kang, JY et al. (2009) Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31 873-84 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Takeuchi, O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 443-51 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Kielian, T et al. (2005) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect. Immun. 73 7428-35 PubMed GONUTS page
↑ Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Takeuchi, O et al. (2000) Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165 5392-6 PubMed GONUTS page
↑ Tanne, A et al. (2009) A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J. Exp. Med. 206 2205-20 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Jin, MS et al. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130 1071-82 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Brown, GD et al. (2003) Dectin-1 mediates the biological effects of beta-glucans. J. Exp. Med. 197 1119-24 PubMed GONUTS page
↑ Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Mullaly, SC & Kubes, P (2006) The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J. Immunol. 177 8154-63 PubMed GONUTS page
↑ Watanabe, T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5 800-8 PubMed GONUTS page
↑ Alexopoulou, L et al. (2002) Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat. Med. 8 878-84 PubMed GONUTS page
↑ Kamda, JD & Singer, SM (2009) Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect. Immun. 77 685-93 PubMed GONUTS page

[PMID:15501775-1] Mandell, L et al. (2004) Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect. Immun. 72 6446-54 PubMed GONUTS page

[PMID:22198949-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Liu, S et al. (2012) TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. J. Immunol. 188 1098-107 PubMed GONUTS page

[PMID:15356140-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22033934-5] 5.0 ^5.1 ^5.2 Anand, PK et al. (2011) TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J. Biol. Chem. 286 42981-91 PubMed GONUTS page

[PMID:16949315-6] 6.0 ^6.1 Watanabe, T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25 473-85 PubMed GONUTS page

[PMID:15690042-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Hoebe, K et al. (2005) CD36 is a sensor of diacylglycerides. Nature 433 523-7 PubMed GONUTS page

[PMID:19931471-8] 8.0 ^8.1 ^8.2 ^8.3 Kang, JY et al. (2009) Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31 873-84 PubMed GONUTS page

[PMID:10549626-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Takeuchi, O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 443-51 PubMed GONUTS page

[PMID:16239543-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Kielian, T et al. (2005) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect. Immun. 73 7428-35 PubMed GONUTS page

[PMID:19139201-11] Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page

[PMID:11067888-12] 12.0 ^12.1 ^12.2 ^12.3 Takeuchi, O et al. (2000) Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165 5392-6 PubMed GONUTS page

[PMID:19770268-13] Tanne, A et al. (2009) A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J. Exp. Med. 206 2205-20 PubMed GONUTS page

[PMID:17889651-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Jin, MS et al. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130 1071-82 PubMed GONUTS page

[PMID:12719478-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Brown, GD et al. (2003) Dectin-1 mediates the biological effects of beta-glucans. J. Exp. Med. 197 1119-24 PubMed GONUTS page

[PMID:18261938-16] Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page

[PMID:17114491-17] 17.0 ^17.1 ^17.2 Mullaly, SC & Kubes, P (2006) The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J. Immunol. 177 8154-63 PubMed GONUTS page

[PMID:15220916-18] Watanabe, T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5 800-8 PubMed GONUTS page

[PMID:12091878-19] Alexopoulou, L et al. (2002) Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat. Med. 8 878-84 PubMed GONUTS page

[PMID:19047410-20] Kamda, JD & Singer, SM (2009) Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect. Immun. 77 685-93 PubMed GONUTS page

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