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PMID:19770268
| Citation |
Tanne, A, Ma, B, Boudou, F, Tailleux, L, Botella, H, Badell, E, Levillain, F, Taylor, ME, Drickamer, K, Nigou, J, Dobos, KM, Puzo, G, Vestweber, D, Wild, MK, Marcinko, M, Sobieszczuk, P, Stewart, L, Lebus, D, Gicquel, B and Neyrolles, O (2009) A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J. Exp. Med. 206:2205-20 |
|---|---|
| Abstract |
The C-type lectin dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) mediates the innate immune recognition of microbial carbohydrates. We investigated the function of this molecule in the host response to pathogens in vivo, by generating mouse lines lacking the DC-SIGN homologues SIGNR1, SIGNR3, and SIGNR5. Resistance to Mycobacterium tuberculosis was impaired only in SIGNR3-deficient animals. SIGNR3 was expressed in lung phagocytes during infection, and interacted with M. tuberculosis bacilli and mycobacterial surface glycoconjugates to induce secretion of critical host defense inflammatory cytokines, including tumor necrosis factor (TNF). SIGNR3 signaling was dependent on an intracellular tyrosine-based motif and the tyrosine kinase Syk. Thus, the mouse DC-SIGN homologue SIGNR3 makes a unique contribution to protection of the host against a pulmonary bacterial pathogen. |
| Links |
PubMed PMC2757888 Online version:10.1084/jem.20090188 |
| Keywords |
Animals; Antigens, CD/physiology; Cell Adhesion Molecules/physiology; Extracellular Signal-Regulated MAP Kinases/physiology; Female; Glycoconjugates/metabolism; Interleukin-6/biosynthesis; Lectins, C-Type/physiology; Lipopolysaccharides/metabolism; Lung/immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B/physiology; Proto-Oncogene Proteins c-raf/physiology; Receptors, Cell Surface/physiology; Signal Transduction; Toll-Like Receptor 2/physiology; Tuberculosis/immunology; Tumor Necrosis Factor-alpha/biosynthesis |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0001819: positive regulation of cytokine production |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:2157947 |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:C209B |
enables |
GO:0005537: mannose binding |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
MOUSE:C209B |
involved_in |
GO:0006897: endocytosis |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:C209D |
enables |
GO:0005537: mannose binding |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
MOUSE:C209D |
involved_in |
GO:0006897: endocytosis |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:C209D |
involved_in |
GO:0001819: positive regulation of cytokine production |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:C209D |
involved_in |
GO:0001819: positive regulation of cytokine production |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:1346060 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:C209D |
involved_in |
GO:0001819: positive regulation of cytokine production |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:99515 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:C209D |
involved_in |
GO:0042742: defense response to bacterium |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:5052162 |
P |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0001819: positive regulation of cytokine production |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:2157947 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050715: positive regulation of cytokine secretion |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:2157947 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050715: positive regulation of cytokine secretion |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:2157947 |
P |
Seeded From UniProt |
complete | ||
See also
References
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