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HUMAN:MYD88

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MYD88
Protein Name(s) Myeloid differentiation primary response protein MyD88
External Links
UniProt Q99836
EMBL U70451
U84408
AB446470
BT007376
AK296570
AK296716
AK298650
AK298666
AP006309
CH471055
BC013589
BI524129
RefSeq NP_001166037.1
NP_001166039.1
NP_001166040.1
NP_002459.2
UniGene Hs.82116
PDB 2JS7
2Z5V
3MOP
4DOM
4EO7
PDBsum 2JS7
2Z5V
3MOP
4DOM
4EO7
ProteinModelPortal Q99836
SMR Q99836
BioGrid 110700
DIP DIP-31349N
IntAct Q99836
MINT MINT-97233
STRING 9606.ENSP00000379625
ChEMBL CHEMBL5919
PhosphoSite Q99836
DMDM 18202671
MaxQB Q99836
PaxDb Q99836
PRIDE Q99836
DNASU 4615
Ensembl ENST00000443433
ENST00000495303
GeneID 4615
KEGG hsa:4615
UCSC uc003chx.3
uc011ayi.2
uc011ayj.2
uc011ayk.2
uc011ayl.2
CTD 4615
GeneCards GC03P038179
HGNC HGNC:7562
HPA CAB009104
HPA042919
MIM 602170
612260
neXtProt NX_Q99836
Orphanet 183713
33226
PharmGKB PA31361
eggNOG NOG70664
GeneTree ENSGT00510000048324
HOGENOM HOG000070050
HOVERGEN HBG052547
InParanoid Q99836
KO K04729
OrthoDB EOG7H792K
PhylomeDB Q99836
Reactome REACT_118563
REACT_13415
REACT_21281
REACT_22442
REACT_24938
REACT_24969
REACT_25024
REACT_25120
REACT_25222
REACT_27215
REACT_6788
SignaLink Q99836
ChiTaRS MYD88
EvolutionaryTrace Q99836
GeneWiki MYD88
GenomeRNAi 4615
NextBio 17764
PRO PR:Q99836
Proteomes UP000005640
Bgee Q99836
CleanEx HS_MYD88
ExpressionAtlas Q99836
Genevestigator Q99836
GO GO:0005829
GO:0010008
GO:0005886
GO:0014069
GO:0043234
GO:0005123
GO:0042802
GO:0070976
GO:0070935
GO:0007166
GO:0071260
GO:0019221
GO:0050830
GO:0090557
GO:0016064
GO:0006954
GO:0045087
GO:0007254
GO:0031663
GO:0002755
GO:0043066
GO:0044130
GO:0048011
GO:0045080
GO:0043123
GO:0032740
GO:0032747
GO:0032755
GO:0046330
GO:0050671
GO:0051092
GO:0048661
GO:0032760
GO:0032481
GO:0050727
GO:0070555
GO:0002238
GO:0032494
GO:0009615
GO:0007165
GO:0008063
GO:0034166
GO:0034134
GO:0034142
GO:0034146
GO:0034162
GO:0002224
GO:0038123
GO:0038124
GO:0045351
Gene3D 1.10.533.10
3.40.50.10140
InterPro IPR011029
IPR000488
IPR017281
IPR000157
Pfam PF00531
PF01582
PIRSF PIRSF037756
SMART SM00005
SM00255
SUPFAM SSF47986
SSF52200
PROSITE PS50017
PS50104

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0002224

toll-like receptor signaling pathway

PMID:PMC3409161

ECO:0000314

P

figure 2 shows cxcl2 activity relate to activator only

complete
CACAO 5106

involved_in

GO:0042742

defense response to bacterium

PMID:20219467[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900017

positive regulation of cytokine production involved in inflammatory response

PMID:20219467[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0042742)

Seeded From UniProt

complete

involved_in

GO:0032757

positive regulation of interleukin-8 production

PMID:20219467[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0042742)

Seeded From UniProt

complete

involved_in

GO:0006909

phagocytosis

PMID:30883606[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900017

positive regulation of cytokine production involved in inflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

regulates_o_occurs_in:(CL:0000235)

Seeded From UniProt

complete

involved_in

GO:0140052

cellular response to oxidised low-density lipoprotein particle stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

  • regulates_o_occurs_in:(CL:0000129)
  • regulates_expression_of:(ENSEMBL:ENSG00000125538)
  • part_of:(GO:1904646)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

  • regulates_o_occurs_in:(CL:0000235)
  • positively_regulates:(GO:0002269)
  • part_of:(GO:0071404)
  • regulates_expression_of:(ENSEMBL:ENSG00000163739)|regulates_o_occurs_in(CL:0000235)
  • positively_regulates:(GO:0002269)
  • part_of:(GO:0071404)
  • regulates_expression_of:(ENSEMBL:ENSG00000081041)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

  • regulates_o_occurs_in:(CL:0000235)
  • positively_regulates:(GO:0002269)
  • part_of:(GO:0071404)
  • regulates_expression_of:(ENSEMBL:ENSG00000125538)

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

PMID:23633945[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:22155231[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043621

protein self-association

PMID:22155231[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:22155231[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22155231[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22155231[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

PMID:23633945[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9013863[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070976

TIR domain binding

PMID:19509286[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P58753

F

Seeded From UniProt

complete

involved_in

GO:0070935

3'-UTR-mediated mRNA stabilization

PMID:15294994[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070555

response to interleukin-1

PMID:19281832[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050727

regulation of inflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

Seeded From UniProt

complete

involved_in

GO:0032755

positive regulation of interleukin-6 production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

Seeded From UniProt

complete

involved_in

GO:0032747

positive regulation of interleukin-23 production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

Seeded From UniProt

complete

involved_in

GO:0032740

positive regulation of interleukin-17 production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

Seeded From UniProt

complete

involved_in

GO:0071260

cellular response to mechanical stimulus

PMID:19593445[9]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P22366

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:12761501[10]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:27107012[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99836

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25910212[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99836

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[13]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99836

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22155231[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99836

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21988832[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99836

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21516116[15]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99836

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:17258210[16]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99836

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:11544529[17]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99836

F

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017281

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000157
InterPro:IPR000488
InterPro:IPR034249

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017281

P

Seeded From UniProt

complete

enables

GO:0070976

TIR domain binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017281

F

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

PMID:9374458[18]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005123

death receptor binding

PMID:9374458[18]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

Reactome:R-HSA-9020702

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

Reactome:R-HSA-193639

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034162

toll-like receptor 9 signaling pathway

Reactome:R-HSA-168138

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032481

positive regulation of type I interferon production

Reactome:R-HSA-1834949

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0010008

endosome membrane

Reactome:R-HSA-975188
Reactome:R-HSA-975180
Reactome:R-HSA-975175
Reactome:R-HSA-975170
Reactome:R-HSA-975160
Reactome:R-HSA-975156
Reactome:R-HSA-975134
Reactome:R-HSA-975125
Reactome:R-HSA-975118
Reactome:R-HSA-975115
Reactome:R-HSA-975111
Reactome:R-HSA-975106
Reactome:R-HSA-975100
Reactome:R-HSA-975098

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-975880
Reactome:R-HSA-975879
Reactome:R-HSA-975878
Reactome:R-HSA-975874
Reactome:R-HSA-975873
Reactome:R-HSA-975866
Reactome:R-HSA-975865
Reactome:R-HSA-975861
Reactome:R-HSA-975857
Reactome:R-HSA-975853
Reactome:R-HSA-975852
Reactome:R-HSA-937079
Reactome:R-HSA-937059
Reactome:R-HSA-937022
Reactome:R-HSA-5602672
Reactome:R-HSA-5602603
Reactome:R-HSA-5602472
Reactome:R-HSA-5602353
Reactome:R-HSA-2262777
Reactome:R-HSA-2262775
Reactome:R-HSA-166363
Reactome:R-HSA-166362
Reactome:R-HSA-166286
Reactome:R-HSA-166284
Reactome:R-HSA-166119
Reactome:R-HSA-166091
Reactome:R-HSA-166082
Reactome:R-HSA-166072

ECO:0000304

author statement supported by traceable reference used in manual assertion




























C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-975880
Reactome:R-HSA-975866
Reactome:R-HSA-975175
Reactome:R-HSA-975098
Reactome:R-HSA-937079
Reactome:R-HSA-5602606
Reactome:R-HSA-5602383
Reactome:R-HSA-5602316
Reactome:R-HSA-450133
Reactome:R-HSA-446894
Reactome:R-HSA-446868
Reactome:R-HSA-446862
Reactome:R-HSA-446701
Reactome:R-HSA-446694
Reactome:R-HSA-446692
Reactome:R-HSA-446684
Reactome:R-HSA-446648
Reactome:R-HSA-446634
Reactome:R-HSA-3134953
Reactome:R-HSA-193695
Reactome:R-HSA-193665
Reactome:R-HSA-166072

ECO:0000304

author statement supported by traceable reference used in manual assertion






















C

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

Reactome:R-HSA-975871
Reactome:R-HSA-166058

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0002224

toll-like receptor signaling pathway

Reactome:R-HSA-168181

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Tang, B et al. (2010) Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation. FEBS Lett. 584 1481-6 PubMed GONUTS page
  2. ↑ Skjesol, A et al. (2019) The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. PLoS Pathog. 15 e1007684 PubMed GONUTS page
  3. ↑ 3.0 3.1 Chen, Y et al. (2013) HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1. PLoS Pathog. 9 e1003248 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Chaudhary, A et al. (2012) The Brucella TIR-like protein TcpB interacts with the death domain of MyD88. Biochem. Biophys. Res. Commun. 417 299-304 PubMed GONUTS page
  5. ↑ Bonnert, TP et al. (1997) The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. FEBS Lett. 402 81-4 PubMed GONUTS page
  6. ↑ Nagpal, K et al. (2009) A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J. Biol. Chem. 284 25742-8 PubMed GONUTS page
  7. ↑ Datta, S et al. (2004) Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA. J. Immunol. 173 2755-61 PubMed GONUTS page
  8. ↑ Luo, SF et al. (2009) Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. Toxicol. Appl. Pharmacol. 237 8-21 PubMed GONUTS page
  9. ↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
  10. ↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
  11. ↑ Yachie, N et al. (2016) Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol. Syst. Biol. 12 863 PubMed GONUTS page
  12. ↑ Sahni, N et al. (2015) Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161 647-660 PubMed GONUTS page
  13. ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  14. ↑ Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page
  15. ↑ Yu, H et al. (2011) Next-generation sequencing to generate interactome datasets. Nat. Methods 8 478-80 PubMed GONUTS page
  16. ↑ Ulrichts, P et al. (2007) MAPPIT analysis of TLR adaptor complexes. FEBS Lett. 581 629-36 PubMed GONUTS page
  17. ↑ Fitzgerald, KA et al. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413 78-83 PubMed GONUTS page
  18. ↑ 18.0 18.1 Muzio, M et al. (1997) IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278 1612-5 PubMed GONUTS page
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