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DROME:HID

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) W (synonyms: Hid)
Protein Name(s) Cell death protein W

Protein head involution defective Protein wrinkled

External Links
UniProt Q24106
EMBL U31226
AE014296
AY075188
RefSeq NP_001262010.1
NP_524136.2
UniGene Dm.5624
PDB 1JD6
PDBsum 1JD6
BioGrid 65293
DIP DIP-20052N
IntAct Q24106
MINT MINT-824104
STRING 7227.FBpp0074899
EnsemblMetazoa FBtr0075133
FBtr0332862
GeneID 40009
KEGG dme:Dmel_CG5123
FlyBase FBgn0003997
eggNOG NOG237676
InParanoid Q24106
OMA EDEREYQ
OrthoDB EOG7BP83P
PhylomeDB Q24106
ChiTaRS W
GenomeRNAi 40009
NextBio 816537
Proteomes UP000000803
Bgee Q24106
ExpressionAtlas Q24106
GO GO:0005739
GO:0048800
GO:0006915
GO:0097190
GO:0008219
GO:0071480
GO:0009267
GO:0046667
GO:0048813
GO:0035072
GO:0043153
GO:0008258
GO:0002165
GO:0008630
GO:0035096
GO:0007424
GO:0043065
GO:2000685
GO:2001056
GO:0016239
GO:0012501
GO:0043281
GO:0046620
GO:0046668
GO:0010114
GO:0035071
GO:0007548

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008219

cell death

PMID:7622034[1]

ECO:0000315

P

Figures 1, 3, and 4

complete
CACAO 3546

involved_in

GO:1904747

positive regulation of apoptotic process involved in development

PMID:22615583[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008219

cell death

PMID:7622034[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071480

cellular response to gamma radiation

PMID:24265704[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:20837774[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:19100727[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009267

cellular response to starvation

PMID:18794330[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:18794330[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:18688282[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:18166655[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[9]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0033051

P

Seeded From UniProt

complete

enables

GO:1990525

BIR domain binding

PMID:16485033[9]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0015247

F

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:16485033[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[9]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0026404

P

Seeded From UniProt

complete

involved_in

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[9]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0019972

P

Seeded From UniProt

complete

involved_in

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[9]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0263864

P

Seeded From UniProt

complete

involved_in

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[9]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0028381

P

Seeded From UniProt

complete

enables

GO:1990525

BIR domain binding

PMID:16485033[9]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0260635

F

Seeded From UniProt

complete

involved_in

GO:0048813

dendrite morphogenesis

PMID:16980964[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008219

cell death

PMID:16280349[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0012501

programmed cell death

PMID:16168982[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007424

open tracheal system development

PMID:16198330[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048800

antennal morphogenesis

PMID:15464574[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035071

salivary gland cell autophagic cell death

PMID:15150408[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035071

salivary gland cell autophagic cell death

PMID:15150408[15]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0011706

P

Seeded From UniProt

complete

involved_in

GO:0035096

larval midgut cell programmed cell death

PMID:15150408[15]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0011706

P

Seeded From UniProt

complete

involved_in

GO:2001272

positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

PMID:15107838[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043153

entrainment of circadian clock by photoperiod

PMID:14960620[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010114

response to red light

PMID:14960620[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046620

regulation of organ growth

PMID:15066286[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000685

positive regulation of cellular response to X-ray

PMID:14729967[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007548

sex differentiation

PMID:12919673[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

DOI:10.1016/S0168-9525(02)02778-6

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046668

regulation of retinal cell programmed cell death

PMID:12547518[21]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:12021769[22]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0260635

F

Seeded From UniProt

complete

involved_in

GO:0035072

ecdysone-mediated induction of salivary gland cell autophagic cell death

PMID:10882130[23]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097190

apoptotic signaling pathway

PMID:10481910[24]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0260635

P

Seeded From UniProt

complete

involved_in

GO:2001056

positive regulation of cysteine-type endopeptidase activity

PMID:10481910[24]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097190

apoptotic signaling pathway

PMID:10220397[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:10220397[25]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097190

apoptotic signaling pathway

PMID:9814703[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0012501

programmed cell death

PMID:9144202[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0012501

programmed cell death

PMID:9144202[27]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0011706

P

Seeded From UniProt

complete

involved_in

GO:0097190

apoptotic signaling pathway

PMID:7622034[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002165

instar larval or pupal development

PMID:1752422[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008258

head involution

PMID:1752422[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0045476

nurse cell apoptotic process

PMID:12072176[29]
PMID:11139280[30]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0012501

programmed cell death

PMID:12072176[29]
PMID:12006672[31]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0046667

compound eye retinal cell programmed cell death

PMID:11735386[32]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:10910336[33]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Grether, ME et al. (1995) The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev. 9 1694-708 PubMed GONUTS page
  2. ↑ Schoenherr, JA et al. (2012) Drosophila activated Cdc42 kinase has an anti-apoptotic function. PLoS Genet. 8 e1002725 PubMed GONUTS page
  3. ↑ Zhang, C et al. (2013) Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage. PLoS ONE 8 e78652 PubMed GONUTS page
  4. ↑ Sandu, C et al. (2010) Drosophila IAP antagonists form multimeric complexes to promote cell death. J. Cell Biol. 190 1039-52 PubMed GONUTS page
  5. ↑ Tanaka-Matakatsu, M et al. (2009) Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev. Biol. 326 347-56 PubMed GONUTS page
  6. ↑ 6.0 6.1 Hou, YC et al. (2008) Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J. Cell Biol. 182 1127-39 PubMed GONUTS page
  7. ↑ Moon, NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 4 e1000153 PubMed GONUTS page
  8. ↑ Ribeiro, PS et al. (2007) DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. J. Cell Biol. 179 1467-80 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 Leulier, F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 13 1663-74 PubMed GONUTS page
  10. ↑ Williams, DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat. Neurosci. 9 1234-6 PubMed GONUTS page
  11. ↑ Werz, C et al. (2005) Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development 132 5343-52 PubMed GONUTS page
  12. ↑ Rodriguez Moncalvo, VG & Campos, AR (2005) Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev. Biol. 286 549-58 PubMed GONUTS page
  13. ↑ Guha, A & Kornberg, TB (2005) Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium. Dev. Biol. 287 192-200 PubMed GONUTS page
  14. ↑ Cullen, K & McCall, K (2004) Role of programmed cell death in patterning the Drosophila antennal arista. Dev. Biol. 275 82-92 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 Yin, VP & Thummel, CS (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 8022-7 PubMed GONUTS page
  16. ↑ Yan, N et al. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat. Struct. Mol. Biol. 11 420-8 PubMed GONUTS page
  17. ↑ 17.0 17.1 Klarsfeld, A et al. (2004) Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J. Neurosci. 24 1468-77 PubMed GONUTS page
  18. ↑ de la Cova, C et al. (2004) Drosophila myc regulates organ size by inducing cell competition. Cell 117 107-16 PubMed GONUTS page
  19. ↑ Brodsky, MH et al. (2004) Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell. Biol. 24 1219-31 PubMed GONUTS page
  20. ↑ DeFalco, TJ et al. (2003) Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev. Cell 5 205-16 PubMed GONUTS page
  21. ↑ Brachmann, CB & Cagan, RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet. 19 91-6 PubMed GONUTS page
  22. ↑ Ryoo, HD et al. (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell Biol. 4 432-8 PubMed GONUTS page
  23. ↑ Jiang, C et al. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Mol. Cell 5 445-55 PubMed GONUTS page
  24. ↑ 24.0 24.1 Wang, SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98 453-63 PubMed GONUTS page
  25. ↑ 25.0 25.1 Haining, WN et al. (1999) The proapoptotic function of Drosophila Hid is conserved in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 96 4936-41 PubMed GONUTS page
  26. ↑ Kurada, P & White, K (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95 319-29 PubMed GONUTS page
  27. ↑ 27.0 27.1 Zhou, L et al. (1997) Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc. Natl. Acad. Sci. U.S.A. 94 5131-6 PubMed GONUTS page
  28. ↑ 28.0 28.1 Abbott, MK & Lengyel, JA (1991) Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective. Genetics 129 783-9 PubMed GONUTS page
  29. ↑ 29.0 29.1 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
  30. ↑ Buszczak, M & Cooley, L (2000) Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ. 7 1071-4 PubMed GONUTS page
  31. ↑ Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page
  32. ↑ Baker, NE (2001) Cell proliferation, survival, and death in the Drosophila eye. Semin. Cell Dev. Biol. 12 499-507 PubMed GONUTS page
  33. ↑ De Laurenzi, V & Melino, G (2000) Apoptosis. The little devil of death. Nature 406 135-6 PubMed GONUTS page
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