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DROME:HID

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) W (synonyms: Hid)
Protein Name(s) Cell death protein W

Protein head involution defective Protein wrinkled

External Links
UniProt Q24106
EMBL U31226
AE014296
AY075188
RefSeq NP_001262010.1
NP_524136.2
UniGene Dm.5624
PDB 1JD6
PDBsum 1JD6
BioGrid 65293
DIP DIP-20052N
IntAct Q24106
MINT MINT-824104
STRING 7227.FBpp0074899
EnsemblMetazoa FBtr0075133
FBtr0332862
GeneID 40009
KEGG dme:Dmel_CG5123
FlyBase FBgn0003997
eggNOG NOG237676
InParanoid Q24106
OMA EDEREYQ
OrthoDB EOG7BP83P
PhylomeDB Q24106
ChiTaRS W
GenomeRNAi 40009
NextBio 816537
Proteomes UP000000803
Bgee Q24106
ExpressionAtlas Q24106
GO GO:0005739
GO:0048800
GO:0006915
GO:0097190
GO:0008219
GO:0071480
GO:0009267
GO:0046667
GO:0048813
GO:0035072
GO:0043153
GO:0008258
GO:0002165
GO:0008630
GO:0035096
GO:0007424
GO:0043065
GO:2000685
GO:2001056
GO:0016239
GO:0012501
GO:0043281
GO:0046620
GO:0046668
GO:0010114
GO:0035071
GO:0007548

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0008219

cell death

PMID:7622034[1]

IMP: Inferred from Mutant Phenotype

P

Figures 1, 3, and 4

complete
CACAO 3546

GO:0002165

instar larval or pupal development

PMID:1752422[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10481910[3]

IPI: Inferred from Physical Interaction

FB:FBgn0260635

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10481910[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10675328[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021769[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021771[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14517550[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:10220397[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006915

apoptotic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10910336[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:20837774[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007424

open tracheal system development

PMID:16198330[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007548

sex differentiation

PMID:12919673[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008219

cell death

PMID:16280349[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008219

cell death

PMID:7622034[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008258

head involution

PMID:1752422[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:18688282[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009267

cellular response to starvation

PMID:18794330[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010114

response to red light

PMID:14960620[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:12006672[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:12072176[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:16168982[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:9144202[20]

IGI: Inferred from Genetic Interaction

FB:FBgn0011706

P

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:9144202[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016239

positive regulation of macroautophagy

PMID:18794330[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

PMID:12021769[5]

IPI: Inferred from Physical Interaction

FB:FBgn0260635

F

Seeded From UniProt

complete

GO:0035071

salivary gland cell autophagic cell death

PMID:15150408[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0011706

P

Seeded From UniProt

complete

GO:0035071

salivary gland cell autophagic cell death

PMID:15150408[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035072

ecdysone-mediated induction of salivary gland cell autophagic cell death

PMID:10882130[22]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0035096

larval midgut cell programmed cell death

PMID:15150408[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0011706

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptotic process

PMID:16485033[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptotic process

PMID:18166655[24]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptotic process

PMID:19100727[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043153

entrainment of circadian clock by photoperiod

PMID:14960620[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[23]

IGI: Inferred from Genetic Interaction

FB:FBgn0019972

P

Seeded From UniProt

complete

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[23]

IGI: Inferred from Genetic Interaction

FB:FBgn0026404

P

Seeded From UniProt

complete

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[23]

IGI: Inferred from Genetic Interaction

FB:FBgn0028381

P

Seeded From UniProt

complete

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[23]

IGI: Inferred from Genetic Interaction

FB:FBgn0033051

P

Seeded From UniProt

complete

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[23]

IGI: Inferred from Genetic Interaction

FB:FBgn0263864

P

Seeded From UniProt

complete

GO:0046620

regulation of organ growth

PMID:15066286[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046667

compound eye retinal cell programmed cell death

PMID:11735386[27]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046668

regulation of retinal cell programmed cell death

PMID:12547518[28]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0048800

antennal morphogenesis

PMID:15464574[29]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048813

dendrite morphogenesis

PMID:16980964[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071480

cellular response to gamma radiation

PMID:24265704[31]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:10220397[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:10481910[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0260635

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:7622034[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:9814703[32]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1990525

BIR domain binding

PMID:16485033[23]

IPI: Inferred from Physical Interaction

FB:FBgn0015247

F

Seeded From UniProt

complete

GO:1990525

BIR domain binding

PMID:16485033[23]

IPI: Inferred from Physical Interaction

FB:FBgn0260635

F

Seeded From UniProt

complete

GO:2000685

positive regulation of cellular response to X-ray

PMID:14729967[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2001056

positive regulation of cysteine-type endopeptidase activity

PMID:10481910[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:2001272

positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

PMID:15107838[34]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

NOT

GO:0045476

nurse cell apoptotic process

PMID:11139280[35]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

NOT

GO:0045476

nurse cell apoptotic process

PMID:12072176[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Grether, ME et al. (1995) The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev. 9 1694-708 PubMed GONUTS page
  2. 2.0 2.1 Abbott, MK & Lengyel, JA (1991) Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective. Genetics 129 783-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Wang, SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98 453-63 PubMed GONUTS page
  4. Goyal, L et al. (2000) Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19 589-97 PubMed GONUTS page
  5. 5.0 5.1 Ryoo, HD et al. (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell Biol. 4 432-8 PubMed GONUTS page
  6. Wilson, R et al. (2002) The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat. Cell Biol. 4 445-50 PubMed GONUTS page
  7. Chai, J et al. (2003) Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat. Struct. Biol. 10 892-8 PubMed GONUTS page
  8. 8.0 8.1 Haining, WN et al. (1999) The proapoptotic function of Drosophila Hid is conserved in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 96 4936-41 PubMed GONUTS page
  9. De Laurenzi, V & Melino, G (2000) Apoptosis. The little devil of death. Nature 406 135-6 PubMed GONUTS page
  10. Sandu, C et al. (2010) Drosophila IAP antagonists form multimeric complexes to promote cell death. J. Cell Biol. 190 1039-52 PubMed GONUTS page
  11. Guha, A & Kornberg, TB (2005) Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium. Dev. Biol. 287 192-200 PubMed GONUTS page
  12. DeFalco, TJ et al. (2003) Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev. Cell 5 205-16 PubMed GONUTS page
  13. Werz, C et al. (2005) Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development 132 5343-52 PubMed GONUTS page
  14. Moon, NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 4 e1000153 PubMed GONUTS page
  15. 15.0 15.1 Hou, YC et al. (2008) Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J. Cell Biol. 182 1127-39 PubMed GONUTS page
  16. 16.0 16.1 Klarsfeld, A et al. (2004) Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J. Neurosci. 24 1468-77 PubMed GONUTS page
  17. Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page
  18. 18.0 18.1 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
  19. Rodriguez Moncalvo, VG & Campos, AR (2005) Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev. Biol. 286 549-58 PubMed GONUTS page
  20. 20.0 20.1 Zhou, L et al. (1997) Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc. Natl. Acad. Sci. U.S.A. 94 5131-6 PubMed GONUTS page
  21. 21.0 21.1 21.2 Yin, VP & Thummel, CS (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 8022-7 PubMed GONUTS page
  22. Jiang, C et al. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Mol. Cell 5 445-55 PubMed GONUTS page
  23. 23.0 23.1 23.2 23.3 23.4 23.5 23.6 23.7 Leulier, F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 13 1663-74 PubMed GONUTS page
  24. Ribeiro, PS et al. (2007) DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. J. Cell Biol. 179 1467-80 PubMed GONUTS page
  25. Tanaka-Matakatsu, M et al. (2009) Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev. Biol. 326 347-56 PubMed GONUTS page
  26. de la Cova, C et al. (2004) Drosophila myc regulates organ size by inducing cell competition. Cell 117 107-16 PubMed GONUTS page
  27. Baker, NE (2001) Cell proliferation, survival, and death in the Drosophila eye. Semin. Cell Dev. Biol. 12 499-507 PubMed GONUTS page
  28. Brachmann, CB & Cagan, RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet. 19 91-6 PubMed GONUTS page
  29. Cullen, K & McCall, K (2004) Role of programmed cell death in patterning the Drosophila antennal arista. Dev. Biol. 275 82-92 PubMed GONUTS page
  30. Williams, DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat. Neurosci. 9 1234-6 PubMed GONUTS page
  31. Zhang, C et al. (2013) Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage. PLoS ONE 8 e78652 PubMed GONUTS page
  32. Kurada, P & White, K (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95 319-29 PubMed GONUTS page
  33. Brodsky, MH et al. (2004) Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell. Biol. 24 1219-31 PubMed GONUTS page
  34. Yan, N et al. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat. Struct. Mol. Biol. 11 420-8 PubMed GONUTS page
  35. Buszczak, M & Cooley, L (2000) Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ. 7 1071-4 PubMed GONUTS page