PMID:7622034

Citation	Grether, ME, Abrams, JM, Agapite, J, White, K and Steller, H (1995) The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev. 9:1694-708
Abstract	Deletions of chromosomal region, 75C1,2 block virtually all programmed cell death (PCD) in the Drosophila embryo. We have identified a gene previously in this interval, reaper (rpr), which encodes an important regulator of PCD. Here we report the isolation of a second gene in this region, head involution defective (hid), which plays a similar role in PCD. hid mutant embryos have decreased levels of cell death and contain extra cells in the head. We have cloned the hid gene and find that its expression is sufficient to induce PCD in cell death defective mutants. The hid gene appears to encode a novel 410-amino-acid protein, and its mRNA is expressed in regions of the embryo where cell death occurs. Ectopic expression of hid in the Drosophila retina results in eye ablation. This phenotype can be suppressed completely by expression of the anti-apoptotic p35 protein from baculovirus, indicating that p35 may act genetically downstream from hid.
Links	PubMed
Keywords	Alleles; Amino Acid Sequence; Animals; Apoptosis/genetics; Base Sequence; Chromosome Mapping; Cloning, Molecular; DNA/genetics; DNA Primers/genetics; Drosophila Proteins; Drosophila melanogaster/cytology; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Eye Abnormalities/embryology; Eye Abnormalities/genetics; Gene Deletion; Genes, Insect; Models, Genetic; Molecular Sequence Data; Neuropeptides/genetics; RNA, Messenger/genetics
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