PMID:10882130

Citation	Jiang, C, Lamblin, AF, Steller, H and Thummel, CS (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Mol. Cell 5:445-55
Abstract	The steroid hormone ecdysone signals the stage-specific programmed cell death of the larval salivary glands during Drosophila metamorphosis. This response is preceded by an ecdysone-triggered switch in gene expression in which the diap2 death inhibitor is repressed and the reaper (rpr) and head involution defective (hid) death activators are induced. Here we show that rpr is induced directly by the ecdysone-receptor complex through an essential response element in the rpr promoter. The Broad-Complex (BR-C) is required for both rpr and hid transcription, while E74A is required for maximal levels of hid induction. diap2 induction is dependent on betaFTZ-F1, while E75A and E75B are each sufficient to repress diap2. This study identifies transcriptional regulators of programmed cell death in Drosophila and provides a direct link between a steroid signal and a programmed cell death response.
Links	PubMed
Keywords	Animals; Apoptosis/genetics; DNA-Binding Proteins/metabolism; Dimerization; Drosophila/embryology; Drosophila/genetics; Drosophila Proteins; Ecdysone/pharmacology; Fushi Tarazu Transcription Factors; Gene Expression Regulation, Developmental; Homeodomain Proteins; Inhibitor of Apoptosis Proteins; Insect Proteins/genetics; Insect Proteins/metabolism; Metamorphosis, Biological; Neuropeptides/genetics; Peptides/genetics; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid/metabolism; Response Elements; Salivary Glands/cytology; Signal Transduction; Steroidogenic Factor 1; Transcription Factors/metabolism; Transcription, Genetic
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