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PMID:16980964

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Citation

Williams, DW, Kondo, S, Krzyzanowska, A, Hiromi, Y and Truman, JW (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat. Neurosci. 9:1234-6

Abstract

Pruning is important for sculpting neural circuits, as it removes excessive or inaccurate projections. Here we show that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity. Suppressing caspase activity prevented dendrite removal, whereas a global activation of caspases within a neuron caused cell death. A new genetically encoded caspase probe revealed that caspase activity is confined to the degenerating dendrites of pruning neurons.

Links

PubMed Online version:10.1038/nn1774

Keywords

Analysis of Variance; Animals; Animals, Genetically Modified; Apoptosis; Caspases/genetics; Caspases/metabolism; Dendrites/enzymology; Dendrites/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster; Enzyme Activation/physiology; Enzyme Inhibitors/pharmacology; Fluorescent Antibody Technique/methods; Ganglia, Spinal/cytology; Neurons, Afferent/cytology; Time Factors

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q7KLI1

involved_in

GO:0048813: dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9U8R4

involved_in

GO:0048813: dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DRONC

involved_in

GO:0048813: dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:HID

involved_in

GO:0048813: dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:ICENC

involved_in

GO:0048813: dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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