MOUSE:BBC3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bbc3 (synonyms: Puma)
Protein Name(s)	Bcl-2-binding component 3 p53 up-regulated modulator of apoptosis
External Links
UniProt	Q99ML1
EMBL	AF332560 BC044782 BC060370
CCDS	CCDS20847.1
RefSeq	NP_573497.1 XP_006539640.1 XP_006539641.1 XP_006539642.1 XP_006539643.1 XP_006539644.1 XP_006539645.1
UniGene	Mm.7660
PDB	2ROC 2VOF
PDBsum	2ROC 2VOF
ProteinModelPortal	Q99ML1
SMR	Q99ML1
BioGrid	228430
DIP	DIP-29805N
IntAct	Q99ML1
PhosphoSite	Q99ML1
MaxQB	Q99ML1
PRIDE	Q99ML1
Ensembl	ENSMUST00000002152
GeneID	170770
KEGG	mmu:170770
UCSC	uc009fho.2
CTD	27113
MGI	MGI:2181667
eggNOG	NOG39678
GeneTree	ENSGT00390000002767
HOGENOM	HOG000060256
HOVERGEN	HBG050671
InParanoid	Q99ML1
KO	K10132
OMA	CEPGLPA
OrthoDB	EOG74FF2T
PhylomeDB	Q99ML1
TreeFam	TF338776
EvolutionaryTrace	Q99ML1
NextBio	370391
PRO	PR:Q99ML1
Proteomes	UP000000589
Bgee	Q99ML1
CleanEx	MM_BBC3
ExpressionAtlas	Q99ML1
Genevestigator	Q99ML1
GO	GO:0005740 GO:0005739 GO:0006919 GO:0097190 GO:0006974 GO:0071479 GO:0008340 GO:0097194 GO:0072332 GO:0042771 GO:0070059 GO:0030308 GO:0045926 GO:0043065 GO:2001056 GO:0043525 GO:1900740 GO:0070245 GO:0001836 GO:0034976 GO:1901998

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043065	positive regulation of apoptosis	PMID:20818388^[1]	ECO:0000315			P		Puma-deficiency rescued the atrophy of testes, and prevented the depletion of adult stem cells in the bone marrow, testes and brain of p53TSD/– mice (Figs 3a, b and 5d, f and Supplementary Information, Fig. S4).	complete
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	PMID:20818388^[1]	ECO:0000315			P		Consistent with the critical roles of Puma in p53-dependent apoptosis, The partial rescue of thymocytes by Puma-deficiency is probably due to the increased expression of other p53-target genes such as p21 and Bax in the thymus of p53TSD/–Puma–/– mice (Fig. 5j).	complete
	GO:0008285	negative regulation of cell proliferation	PMID:20818388^[1]	ECO:0000315			P		Four-month-old p53TSD/–Puma–/– mice were phenotypically similar to wild-type mice (Fig. 5a). p53TSD/–Puma–/– mice are also similar to wild-type mice in growth rate (Fig. 5b)	complete
	GO:0090343	positive regulation of cell aging	PMID:20818388^[1]	ECO:0000315			P		All p53TSD/–Puma–/– mice survived longer than 6 weeks of age, whereas all p53TSD/– mice died (Fig. 5c).	complete
	GO:0071865	regulation of apoptosis in bone marrow	PMID:20818388^[1]	ECO:0000315			P		Puma-deficiency rescued the atrophy of testes, and prevented the depletion of adult stem cells in the bone marrow, testes and brain of p53TSD/– mice (Figs 3a, b and 5d, f and Supplementary Information, Fig. S4). Note: a new more specific term (Positive regulation of apoptosis in haematopoietic stem cells) is suggested.	complete
	GO:0048133	male germ-line stem cell division	PMID:20818388^[1]	ECO:0000315			P		Puma-deficiency rescued the atrophy of testes, and prevented the depletion of adult stem cells in the bone marrow, testes and brain of p53TSD/– mice (Figs 3a, b and 5d, f and Supplementary Information, Fig. S4). Note: a new more specific term (Negative regulation of male germ-line stem cell division) is suggested	complete
	GO:2000178	negative regulation of neural precursor cell proliferation	PMID:20818388^[1]	ECO:0000315			P		Puma-deficiency rescued the atrophy of testes, and prevented the depletion of adult stem cells in the bone marrow, testes and brain of p53TSD/– mice (Figs 3a, b and 5d, f and Supplementary Information, Fig. S4).	complete
	GO:0070245	positive regulation of thymocyte apoptosis	PMID:20818388^[1]	ECO:0000315			P		Puma-deficiency also prevented anaemia and partially rescued the thymocyte-reduction phenotype in p53TSD/– mice (Fig. 5e and Supplementary Information, Fig. S4d).	complete
	GO:0050680	negative regulation of epithelial cell proliferation	PMID:20818388^[1]	ECO:0000315			P		Figure S6 Apoptosis is significantly increased in the crypt of small intestine of p53TSD/- mice, but suppressed to normal levels by Puma-deficiency.	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXH1	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80ZG6	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:16407291^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070245	positive regulation of thymocyte apoptotic process	PMID:20818388^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:20818388^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:20818388^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	PMID:21159964^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	PMID:22761832^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	PMID:11463391^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXH1	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:21159964^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:22761832^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045926	negative regulation of growth	PMID:11463391^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXH1	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:21159964^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:22761832^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:21159964^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:11463391^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXH1	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:11463391^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXH1	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:11463391^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXH1	P		Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2181667 PANTHER:PTN002008808	P		Seeded From UniProt	complete
involved_in	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2181667 PANTHER:PTN002008808 UniProtKB:Q96PG8	P		Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008808 UniProtKB:Q96PG8	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008808 UniProtKB:Q96PG8	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2181667 PANTHER:PTN002008808 UniProtKB:Q96PG8	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2181667 PANTHER:PTN002008808	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008808 UniProtKB:Q96PG8	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008808 RGD:631434 UniProtKB:Q96PG8	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008808 UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631434	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901998	toxin transport	PMID:23716698^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	PMID:16705087^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681654	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097194	execution phase of apoptosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXH1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097194	execution phase of apoptosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:11572983^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:U82987	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXH1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PMID:11463391^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:AF322558	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071479	cellular response to ionizing radiation	PMID:16286009^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096393 MGI:MGI:98834	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045926	negative regulation of growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:16832056^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681654	P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:14500851^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681654	P	regulates_o_occurs_in:(CL:0000057)\|regulates_o_occurs_in:(CL:0000542)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:16151013^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681654	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032464	positive regulation of protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	PMID:11463391^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:AF332558	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
colocalizes_with	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	C		Seeded From UniProt	complete
part_of	GO:0005740	mitochondrial envelope	PMID:11463391^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:AF332558	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631434	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PG8	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0032471	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031661	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031661	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031661	P		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031661	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Liu, D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat. Cell Biol. 12 993-8 PubMed GONUTS page
↑ Li, J et al. (2006) Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J. Biol. Chem. 281 7260-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Galehdar, Z et al. (2010) Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J. Neurosci. 30 16938-48 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ghosh, AP et al. (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7 e39586 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Yu, J et al. (2001) PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7 673-82 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Slater, LH et al. (2013) CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc. Natl. Acad. Sci. U.S.A. 110 9932-7 PubMed GONUTS page
↑ Ekert, PG et al. (2006) Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood 108 1461-8 PubMed GONUTS page
↑ Han, J et al. (2001) Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc. Natl. Acad. Sci. U.S.A. 98 11318-23 PubMed GONUTS page
↑ Wu, WS et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123 641-53 PubMed GONUTS page
↑ Bauer, A et al. (2006) The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc. Natl. Acad. Sci. U.S.A. 103 10979-84 PubMed GONUTS page
↑ Villunger, A et al. (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302 1036-8 PubMed GONUTS page
↑ Chipuk, JE et al. (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309 1732-5 PubMed GONUTS page

[PMID:20818388-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Liu, D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat. Cell Biol. 12 993-8 PubMed GONUTS page

[PMID:16407291-2] Li, J et al. (2006) Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J. Biol. Chem. 281 7260-70 PubMed GONUTS page

[PMID:21159964-3] 3.0 ^3.1 ^3.2 ^3.3 Galehdar, Z et al. (2010) Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J. Neurosci. 30 16938-48 PubMed GONUTS page

[PMID:22761832-4] 4.0 ^4.1 ^4.2 Ghosh, AP et al. (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7 e39586 PubMed GONUTS page

[PMID:11463391-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Yu, J et al. (2001) PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7 673-82 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23716698-7] Slater, LH et al. (2013) CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc. Natl. Acad. Sci. U.S.A. 110 9932-7 PubMed GONUTS page

[PMID:16705087-8] Ekert, PG et al. (2006) Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood 108 1461-8 PubMed GONUTS page

[PMID:11572983-9] Han, J et al. (2001) Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc. Natl. Acad. Sci. U.S.A. 98 11318-23 PubMed GONUTS page

[PMID:16286009-10] Wu, WS et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123 641-53 PubMed GONUTS page

[PMID:16832056-11] Bauer, A et al. (2006) The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc. Natl. Acad. Sci. U.S.A. 103 10979-84 PubMed GONUTS page

[PMID:14500851-12] Villunger, A et al. (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302 1036-8 PubMed GONUTS page

[PMID:16151013-13] Chipuk, JE et al. (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309 1732-5 PubMed GONUTS page

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MOUSE:BBC3

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