HUMAN:BTK

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BTK (synonyms: AGMX1, ATK, BPK)
Protein Name(s)	Tyrosine-protein kinase BTK Agammaglobulinemia tyrosine kinase ATK B-cell progenitor kinase BPK Bruton tyrosine kinase
External Links
UniProt	Q06187
EMBL	X58957 U10087 U10084 U10085 U10086 L31572 L31557 L31558 L31559 L31561 L31563 L31564 L31565 L31566 L31567 L31568 L31569 L31570 L31571 U13433 U13410 U13412 U13413 U13414 U13415 U13416 U13417 U13422 U13423 U13424 U13425 U13427 U13428 U13429 U13430 U13431 U13432 U78027 AK314382 AL035422 BC109079 BC109080
CCDS	CCDS14482.1 CCDS76003.1
PIR	I37212
RefSeq	NP_000052.1 NP_001274273.1 NP_001274274.1
UniGene	Hs.159494 Hs.733206
PDB	1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3 4NWM 4OT5 4OT6 4OTQ 4OTR
PDBsum	1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3 4NWM 4OT5 4OT6 4OTQ 4OTR
ProteinModelPortal	Q06187
SMR	Q06187
BioGrid	107160
DIP	DIP-34071N
IntAct	Q06187
MINT	MINT-110243
STRING	9606.ENSP00000308176
BindingDB	Q06187
ChEMBL	CHEMBL5251
GuidetoPHARMACOLOGY	1948
PhosphoSite	Q06187
DMDM	547759
MaxQB	Q06187
PaxDb	Q06187
PRIDE	Q06187
DNASU	695
Ensembl	ENST00000308731 ENST00000621635
GeneID	695
KEGG	hsa:695
UCSC	uc004ehg.2
CTD	695
GeneCards	GC0XM100604
GeneReviews	BTK
HGNC	HGNC:1133
HPA	CAB016689 HPA001198 HPA002028
MIM	300300 300755 307200
neXtProt	NX_Q06187
Orphanet	632 47
PharmGKB	PA25454
eggNOG	COG0515
GeneTree	ENSGT00760000119011
HOGENOM	HOG000233859
HOVERGEN	HBG008761
InParanoid	Q06187
KO	K07370
OMA	KYGKWQG
PhylomeDB	Q06187
TreeFam	TF351634
BRENDA	2.7.10.2
Reactome	REACT_118700 REACT_147814 REACT_160086 REACT_163834 REACT_6788
SignaLink	Q06187
ChiTaRS	BTK
EvolutionaryTrace	Q06187
GeneWiki	Bruton%27s_tyrosine_kinase
GenomeRNAi	695
NextBio	2850
PRO	PR:Q06187
Proteomes	UP000005640
Bgee	Q06187
CleanEx	HS_BTK
ExpressionAtlas	Q06187
Genevestigator	Q06187
GO	GO:0005737 GO:0005829 GO:0043231 GO:0045121 GO:0005634 GO:0005886 GO:0005524 GO:0042802 GO:0046872 GO:0004715 GO:0005547 GO:0004713 GO:0002250 GO:0097190 GO:0042113 GO:0050853 GO:0019722 GO:0038095 GO:0045087 GO:0035556 GO:0007498 GO:0002755 GO:0018108 GO:0045579 GO:0051092 GO:0006468 GO:0002902 GO:0002721 GO:0034134 GO:0034142 GO:0002224 GO:0038123 GO:0038124 GO:0006351
Gene3D	2.30.29.30 3.30.505.10
InterPro	IPR011009 IPR001849 IPR011993 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635 IPR001562
Pfam	PF00779 PF00169 PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00402 PR00109
SMART	SM00107 SM00233 SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS50003 PS00107 PS50011 PS00109 PS50001 PS50002 PS51113

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:11606584^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:15046600^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17823121^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17823121^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	PMID:17823121^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700360 UniProtKB:P42680	P	Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102960 MGI:MGI:96621 PANTHER:PTN000700360	P	Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231474 UniProtKB:P42680	P	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231474 UniProtKB:P42680 UniProtKB:P51813 UniProtKB:Q08881	F	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102960 MGI:MGI:96621 PANTHER:PTN000700360	P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:7518558^[5]	ECO:0000269	experimental evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:11577348^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q06187	F	Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0002553	C	Seeded From UniProt	complete
involved_in	GO:0098761	cellular response to interleukin-7	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	P	Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	C	Seeded From UniProt	complete
	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:11606584^[1]	ECO:0000314			P	When two additional peptides incorporating either the Y753F (peptide 2) or Y759F (peptide 3) mutation were used, it was shown that Tyr753 was phosphorylated in preference to Tyr759 (Fig. 6 B).	complete CACAO 9302
involved_in	GO:0030889	negative regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	P	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	P	Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	C	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	F	Seeded From UniProt	complete
involved_in	GO:0002344	B cell affinity maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	P	Seeded From UniProt	complete
involved_in	GO:0001818	negative regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35991 ensembl:ENSMUSP00000033617	P	Seeded From UniProt	complete
involved_in	GO:0071226	cellular response to molecule of fungal origin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	C	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	F	Seeded From UniProt	complete
involved_in	GO:0002553	histamine secretion by mast cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P	Seeded From UniProt	complete
involved_in	GO:0001812	positive regulation of type I hypersensitivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P	Seeded From UniProt	complete
involved_in	GO:0001805	positive regulation of type III hypersensitivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001562	P	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F	Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:8688094^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	PMID:8013627^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15046600^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:11913944^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:15046600^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11913944^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:11913944^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11913944^[9] Reactome:R-HSA-2424487 Reactome:R-HSA-2201322	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045579	positive regulation of B cell differentiation	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042113	B cell activation	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19290921^[10] Reactome:R-HSA-1112666	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19290921^[10] Reactome:R-HSA-9606151 Reactome:R-HSA-937079 Reactome:R-HSA-937059 Reactome:R-HSA-937022 Reactome:R-HSA-8964340 Reactome:R-HSA-8964333 Reactome:R-HSA-8964317 Reactome:R-HSA-8964284 Reactome:R-HSA-8964280 Reactome:R-HSA-8964274 Reactome:R-HSA-8964271 Reactome:R-HSA-8964246 Reactome:R-HSA-8964241 Reactome:R-HSA-5602672 Reactome:R-HSA-5602606 Reactome:R-HSA-5602383 Reactome:R-HSA-5602353 Reactome:R-HSA-2730858 Reactome:R-HSA-2730847 Reactome:R-HSA-2730833 Reactome:R-HSA-2559414 Reactome:R-HSA-2424487 Reactome:R-HSA-2424486 Reactome:R-HSA-2424485 Reactome:R-HSA-2424484 Reactome:R-HSA-2424481 Reactome:R-HSA-2424476 Reactome:R-HSA-2262777 Reactome:R-HSA-2262775 Reactome:R-HSA-2201322 Reactome:R-HSA-166363 Reactome:R-HSA-166362 Reactome:R-HSA-166286 Reactome:R-HSA-166284 Reactome:R-HSA-166119 Reactome:R-HSA-166091 Reactome:R-HSA-166082 Reactome:R-HSA-166072	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002902	regulation of B cell apoptotic process	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002721	regulation of B cell cytokine production	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:19290921^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:R-HSA-166058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Rodriguez, R et al. (2001) Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. J. Biol. Chem. 276 47982-92 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Carpenter, CL (2004) Btk-dependent regulation of phosphoinositide synthesis. Biochem. Soc. Trans. 32 326-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Manna, D et al. (2007) Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains. J. Biol. Chem. 282 32093-105 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kawakami, Y et al. (1994) Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking. Mol. Cell. Biol. 14 5108-13 PubMed GONUTS page
↑ Liu, W et al. (2001) Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. Nat. Immunol. 2 939-46 PubMed GONUTS page
↑ Uckun, FM et al. (1996) BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells. Science 273 1096-100 PubMed GONUTS page
↑ Duriez, B et al. (1994) An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency. FEBS Lett. 346 165-70 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Tsubata, T & Wienands, J (2001) B cell signaling. Introduction. Int. Rev. Immunol. 20 675-8 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Mohamed, AJ et al. (2009) Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol. Rev. 228 58-73 PubMed GONUTS page

[PMID:11606584-1] 1.0 ^1.1 Rodriguez, R et al. (2001) Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. J. Biol. Chem. 276 47982-92 PubMed GONUTS page

[PMID:15046600-2] 2.0 ^2.1 ^2.2 Carpenter, CL (2004) Btk-dependent regulation of phosphoinositide synthesis. Biochem. Soc. Trans. 32 326-9 PubMed GONUTS page

[PMID:17823121-3] 3.0 ^3.1 ^3.2 Manna, D et al. (2007) Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains. J. Biol. Chem. 282 32093-105 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7518558-5] Kawakami, Y et al. (1994) Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking. Mol. Cell. Biol. 14 5108-13 PubMed GONUTS page

[PMID:11577348-6] Liu, W et al. (2001) Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. Nat. Immunol. 2 939-46 PubMed GONUTS page

[PMID:8688094-7] Uckun, FM et al. (1996) BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells. Science 273 1096-100 PubMed GONUTS page

[PMID:8013627-8] Duriez, B et al. (1994) An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency. FEBS Lett. 346 165-70 PubMed GONUTS page

[PMID:11913944-9] 9.0 ^9.1 ^9.2 ^9.3 Tsubata, T & Wienands, J (2001) B cell signaling. Introduction. Int. Rev. Immunol. 20 675-8 PubMed GONUTS page

[PMID:19290921-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Mohamed, AJ et al. (2009) Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol. Rev. 228 58-73 PubMed GONUTS page

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HUMAN:BTK

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