MOUSE:ANXA6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Anxa6 (synonyms: Anx6)
Protein Name(s)	Annexin A6 67 kDa calelectrin Annexin VI Annexin-6 Calphobindin-II CPB-II Chromobindin-20 Lipocortin VI Protein III p68 p70
External Links
UniProt	P14824
EMBL	X13460 AK030728 AK146509 AK146592
CCDS	CCDS24705.1
PIR	S01786
RefSeq	NP_001103681.1 NP_038500.2
UniGene	Mm.265347
ProteinModelPortal	P14824
SMR	P14824
BioGrid	198112
IntAct	P14824
MINT	MINT-1862250
PhosphoSite	P14824
MaxQB	P14824
PaxDb	P14824
PRIDE	P14824
Ensembl	ENSMUST00000108883
GeneID	11749
KEGG	mmu:11749
UCSC	uc007iyr.2
CTD	309
MGI	MGI:88255
eggNOG	NOG267770
GeneTree	ENSGT00760000118972
HOGENOM	HOG000158803
HOVERGEN	HBG061815
InParanoid	P14824
KO	K17094
OMA	EKSLYSM
OrthoDB	EOG74XS72
TreeFam	TF105452
NextBio	279489
PRO	PR:P14824
Proteomes	UP000000589
Bgee	P14824
CleanEx	MM_ANXA6
ExpressionAtlas	P14824
Genevestigator	P14824
GO	GO:0070062 GO:0031902 GO:0005765 GO:0042470 GO:0048471 GO:0005509 GO:0005544 GO:0015485 GO:0005525 GO:0015276 GO:0006816 GO:0051260 GO:0006937
Gene3D	1.10.220.10
InterPro	IPR001464 IPR018502 IPR018252 IPR002393
PANTHER	PTHR10502:SF19
Pfam	PF00191
PRINTS	PR00196 PR00202
SMART	SM00335
PROSITE	PS00223

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0051560	mitochondrial calcium ion homeostasis	PMID:23341998^[1]	ECO:0000315			P		Figure 4	complete CACAO 6375
	GO:0097190	apoptotic signaling pathway	PMID:23341998^[1]	ECO:0000315			P		Figure 6	complete CACAO 6623
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28071719^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000006)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002048)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
involved_in	GO:0051560	mitochondrial calcium ion homeostasis	PMID:23341998^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:23341998^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88255 PANTHER:PTN002574762	P		Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	P		Seeded From UniProt	complete
involved_in	GO:0051560	mitochondrial calcium ion homeostasis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88255 PANTHER:PTN002574762	P		Seeded From UniProt	complete
involved_in	GO:0051283	negative regulation of sequestering of calcium ion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P08133	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	F		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P08133 UniProtKB:P79134	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 RGD:621172	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P08133	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	F		Seeded From UniProt	complete
enables	GO:0035374	chondroitin sulfate binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	F		Seeded From UniProt	complete
involved_in	GO:0031214	biomineral tissue development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	F		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P08133	F		Seeded From UniProt	complete
enables	GO:0015276	ligand-gated ion channel activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P08133	F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	F		Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88255 PANTHER:PTN002574762	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 RGD:621172 UniProtKB:P08133 UniProtKB:P79134	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P08133	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	F		Seeded From UniProt	complete
involved_in	GO:0003418	growth plate cartilage chondrocyte differentiation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	P		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P79134	F		Seeded From UniProt	complete
involved_in	GO:0001778	plasma membrane repair	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 ZFIN:ZDB-GENE-030707-3	P		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574762 UniProtKB:P51901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:15078881^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621172	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621172	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034220	ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621172	C		Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621172	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:23525114^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48037	C		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	F		Seeded From UniProt	complete
enables	GO:0015276	ligand-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	F		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621172	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006937	regulation of muscle contraction	PMID:11919174^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:11919174^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621172	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621172	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621172	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08133	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0051560	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0051560	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005262	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	P		Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	C		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	F		Seeded From UniProt	complete
enables	GO:0015276	ligand-gated ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	F		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08133 ensembl:ENSP00000346550	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001464 InterPro:IPR002393 InterPro:IPR018252 InterPro:IPR018502 InterPro:IPR037104	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001464 InterPro:IPR002393 InterPro:IPR018252 InterPro:IPR018502 InterPro:IPR037104	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-5332993	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0111	F		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Chlystun, M et al. (2013) Regulation of mitochondrial morphogenesis by annexin A6. PLoS ONE 8 e53774 PubMed GONUTS page
↑ Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
↑ ^3.0 ^3.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 ^4.23 ^4.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ te Vruchte, D et al. (2004) Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. J. Biol. Chem. 279 26167-75 PubMed GONUTS page
↑ Alvares, K et al. (2013) Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells. J. Biol. Chem. 288 13036-45 PubMed GONUTS page
↑ ^7.0 ^7.1 Song, G et al. (2002) Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice. FASEB J. 16 622-4 PubMed GONUTS page

[PMID:23341998-1] 1.0 ^1.1 ^1.2 ^1.3 Chlystun, M et al. (2013) Regulation of mitochondrial morphogenesis by annexin A6. PLoS ONE 8 e53774 PubMed GONUTS page

[PMID:28071719-2] Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page

[PMID:22159717-3] 3.0 ^3.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 ^4.23 ^4.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15078881-5] te Vruchte, D et al. (2004) Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. J. Biol. Chem. 279 26167-75 PubMed GONUTS page

[PMID:23525114-6] Alvares, K et al. (2013) Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells. J. Biol. Chem. 288 13036-45 PubMed GONUTS page

[PMID:11919174-7] 7.0 ^7.1 Song, G et al. (2002) Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice. FASEB J. 16 622-4 PubMed GONUTS page

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MOUSE:ANXA6

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Notes

References

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