HUMAN:CD38

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CD38
Protein Name(s)	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 2'-phospho-ADP-ribosyl cyclase 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase 2'-phospho-cyclic-ADP-ribose transferase ADP-ribosyl cyclase 1 ADPRC 1 Cyclic ADP-ribose hydrolase 1 cADPr hydrolase 1 T10
External Links
UniProt	P28907
EMBL	M34461 D84276 D84277 D84284 BC007964
CCDS	CCDS3417.1
PIR	A43521
RefSeq	NP_001766.2
UniGene	Hs.479214
PDB	1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4CMH 4F45 4F46 4OGW
PDBsum	1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4CMH 4F45 4F46 4OGW
ProteinModelPortal	P28907
SMR	P28907
BioGrid	107390
MINT	MINT-4536880
STRING	9606.ENSP00000226279
BindingDB	P28907
ChEMBL	CHEMBL4660
GuidetoPHARMACOLOGY	2766
PhosphoSite	P28907
DMDM	55977782
MaxQB	P28907
PaxDb	P28907
PeptideAtlas	P28907
PRIDE	P28907
DNASU	952
Ensembl	ENST00000226279 ENST00000502843
GeneID	952
KEGG	hsa:952
UCSC	uc003gol.1
CTD	952
GeneCards	GC04P015779
HGNC	HGNC:1667
HPA	CAB002493 CAB025255 HPA022132 HPA052381
MIM	107270
neXtProt	NX_P28907
PharmGKB	PA26214
eggNOG	NOG42596
GeneTree	ENSGT00390000017291
HOGENOM	HOG000293141
HOVERGEN	HBG005277
InParanoid	P28907
KO	K01242
OMA	KNPCNIT
OrthoDB	EOG7RBZ9B
PhylomeDB	P28907
TreeFam	TF332530
BioCyc	MetaCyc:HS00103-MONOMER
SABIO-RK	P28907
EvolutionaryTrace	P28907
GeneWiki	CD38
GenomeRNAi	952
NextBio	3962
PRO	PR:P28907
Proteomes	UP000005640
Bgee	P28907
CleanEx	HS_CD38
ExpressionAtlas	P28907
Genevestigator	P28907
GO	GO:0009986 GO:0070062 GO:0016021 GO:0016020 GO:0005634 GO:0005886 GO:0050135 GO:0003953 GO:0016849 GO:0016740 GO:0097190 GO:0050853 GO:0007565 GO:0060292 GO:0043066 GO:0045779 GO:0045892 GO:0030890 GO:0030307 GO:0007204 GO:0032024 GO:0045893 GO:0045907 GO:0042493 GO:0032355 GO:0033194 GO:0001666 GO:0070555 GO:0032570 GO:0032526 GO:0007165
Gene3D	3.40.50.720
InterPro	IPR003193 IPR016040
PANTHER	PTHR10912
Pfam	PF02267

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0003953	NAD+ nucleosidase activity	PMID:22027397^[1]	ECO:0000315			F	Fig. 5D	complete CACAO 2984
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8253715^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:17875758^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17875758^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17875758^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:17875758^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:17875758^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:17875758^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107474 PANTHER:PTN000857252 UniProtKB:P28907	P	Seeded From UniProt	complete
enables	GO:0016849	phosphorus-oxygen lyase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107474 PANTHER:PTN000857252	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000857252 RGD:2303	C	Seeded From UniProt	complete
enables	GO:0003953	NAD+ nucleosidase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000857252 RGD:2303 UniProtKB:Q10588	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56528 ensembl:ENSMUSP00000030964	F	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56528 ensembl:ENSMUSP00000030964	P	Seeded From UniProt	complete
enables	GO:0016849	phosphorus-oxygen lyase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56528 ensembl:ENSMUSP00000030964	F	Seeded From UniProt	complete
enables	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56528 ensembl:ENSMUSP00000030964	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56528 ensembl:ENSMUSP00000030964	C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56528 ensembl:ENSMUSP00000030964	C	Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0060292	long-term synaptic depression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0045779	negative regulation of bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	C	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0033194	response to hydroperoxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	C	Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	C	Seeded From UniProt	complete
involved_in	GO:0014824	artery smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	C	Seeded From UniProt	complete
enables	GO:0003953	NAD+ nucleosidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	F	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64244 ensembl:ENSRNOP00000004121	P	Seeded From UniProt	complete
enables	GO:0003953	NAD+ nucleosidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003193 InterPro:IPR033567	F	Seeded From UniProt	complete
enables	GO:0050135	NAD(P)+ nucleosidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033567	F	Seeded From UniProt	complete
enables	GO:0050135	NAD(P)+ nucleosidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.2.6	F	Seeded From UniProt	complete
enables	GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.2.6	F	Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:10777496^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8253715^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8253715^[3] Reactome:R-HSA-8938076	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0019674	NAD metabolic process	Reactome:R-HSA-196807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003953	NAD+ nucleosidase activity	Reactome:R-HSA-8938076	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mamik, MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8 145 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Takasawa, S et al. (1993) Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP. J. Biol. Chem. 268 26052-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Han, MK et al. (2000) Interaction of two classes of ADP-ribose transfer reactions in immune signaling. J. Biol. Chem. 275 20799-805 PubMed GONUTS page

[PMID:22027397-1] Mamik, MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8 145 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:8253715-3] 3.0 ^3.1 ^3.2 Takasawa, S et al. (1993) Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP. J. Biol. Chem. 268 26052-4 PubMed GONUTS page

[PMID:17875758-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10777496-6] Han, MK et al. (2000) Interaction of two classes of ADP-ribose transfer reactions in immune signaling. J. Biol. Chem. 275 20799-805 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

HUMAN:CD38

Contents

Annotations

Notes

References

a

b

c

e

f

h

i

l

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools