MOUSE:TYOBP

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tyrobp (synonyms: Dap12, Karap)
Protein Name(s)	TYRO protein tyrosine kinase-binding protein DNAX-activation protein 12 Killer-activating receptor-associated protein KAR-associated protein
External Links
UniProt	O54885
EMBL	AF024637 AF077829 BC056450
CCDS	CCDS21089.1
RefSeq	NP_035792.1
UniGene	Mm.46301
ProteinModelPortal	O54885
SMR	O54885
BioGrid	204396
DIP	DIP-29746N
PhosphoSite	O54885
PRIDE	O54885
Ensembl	ENSMUST00000032800
GeneID	22177
KEGG	mmu:22177
UCSC	uc009gef.1
CTD	7305
MGI	MGI:1277211
eggNOG	NOG44707
HOGENOM	HOG000056440
HOVERGEN	HBG061468
InParanoid	O54885
KO	K07992
OMA	NTQRPYY
OrthoDB	EOG7NW6CH
PhylomeDB	O54885
TreeFam	TF336898
Reactome	REACT_188185 REACT_188188 REACT_215628 REACT_231928
NextBio	302131
PRO	PR:O54885
Proteomes	UP000000589
Bgee	O54885
CleanEx	MM_TYROBP
ExpressionAtlas	O54885
Genevestigator	O54885
GO	GO:0009986 GO:0016021 GO:0005886 GO:0007229 GO:0002281 GO:0002283 GO:2001204
InterPro	IPR026200
PANTHER	PTHR17554

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	Go:0001933	negative regulation of protein phosphorylation	PMID:21727189^[1]	ECO:0000314			P		Figure 3 shows a great increase in phosphorlyation of DAP-12 deficient B-cells than in WT B cells.	complete CACAO 6325
involved_in	GO:0034241	positive regulation of macrophage fusion	PMID:18957693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0048678) occurs_in:(CL:0000129) regulates_o_occurs_in:(UBERON:0001650) part_of:(GO:0002282) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0032911	negative regulation of transforming growth factor beta1 production	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0048678) occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0045081	negative regulation of interleukin-10 biosynthetic process	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0048678) occurs_in:(CL:0000129) part_of:(GO:0002282) regulates_expression_of:(ENSEMBL:ENSMUSG00000022901)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0048678) occurs_in:(CL:0000129) part_of:(GO:0002282) regulates_expression_of:(ENSEMBL:ENSMUSG00000018774)	Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0048678) occurs_in:(CL:0000129) part_of:(GO:0002282)	Seeded From UniProt	complete
involved_in	GO:0050725	positive regulation of interleukin-1 beta biosynthetic process	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0048678) occurs_in:(CL:0000129) part_of:(GO:0002282)	Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0048678) occurs_in:(CL:0000129) part_of:(GO:0002282)	Seeded From UniProt	complete
involved_in	GO:0002282	microglial cell activation involved in immune response	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0048678) occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000129) has_agent:(UBERON:0001650)	Seeded From UniProt	complete
involved_in	GO:0032816	positive regulation of natural killer cell activation	PMID:9647200^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001206	positive regulation of osteoclast development	PMID:14969392^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043277	apoptotic cell clearance	PMID:15728241^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	PMID:18685038^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002421) part_of:(GO:0110090) occurs_in:(CL:0000129) regulates_o_occurs_in:(UBERON:0002421) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	PMID:18685038^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002421) occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0110090	positive regulation of hippocampal neuron apoptotic process	PMID:18685038^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002421) part_of:(GO:0030900) occurs_in:(CL:0000129) regulates_o_occurs_in:(UBERON:0002421) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:18685038^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002421) part_of:(GO:0030900) occurs_in:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:15601948^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000129) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:15601948^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:1902685	positive regulation of receptor localization to synapse	PMID:15601948^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000955) has_regulation_target:(UniProtKB:P15209)\|occurs_in(UBERON:0000955) has_regulation_target:(UniProtKB:P23818)\|occurs_in(UBERON:0000955) has_regulation_target:(UniProtKB:P23819)	Seeded From UniProt	complete
involved_in	GO:0030889	negative regulation of B cell proliferation	PMID:21727189^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002282	microglial cell activation involved in immune response	PMID:25690660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:18691974^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O43914	P		Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	PMID:15601948^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002421) regulates_o_occurs_in:(GO:0098685) occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	PMID:18685038^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:9647200^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:29518356^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99NH8	F	occurs_in:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O43914	C		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:17086186^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002283	neutrophil activation involved in immune response	PMID:17086186^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002281	macrophage activation involved in immune response	PMID:17086186^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001204	regulation of osteoclast development	PMID:22451653^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:3646642	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000010	positive regulation of protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43914	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43914	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034241	positive regulation of macrophage fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030889	negative regulation of B cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43914	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030316	osteoclast differentiation	PMID:21841309^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2179720	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030316	osteoclast differentiation	PMID:21841309^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450834	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030316	osteoclast differentiation	PMID:21841309^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030316	osteoclast differentiation	PMID:21841309^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43914	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43914	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43914	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002274	myeloid leukocyte activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43914	P		Seeded From UniProt	complete
involved_in	GO:2000010	positive regulation of protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43914 ensembl:ENSP00000262629	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43914 ensembl:ENSP00000262629	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43914 ensembl:ENSP00000262629	F		Seeded From UniProt	complete
involved_in	GO:0034241	positive regulation of macrophage fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43914 ensembl:ENSP00000262629	P		Seeded From UniProt	complete
involved_in	GO:0030889	negative regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43914 ensembl:ENSP00000262629	P		Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43914 ensembl:ENSP00000262629	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43914 ensembl:ENSP00000262629	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43914 ensembl:ENSP00000262629	F		Seeded From UniProt	complete
involved_in	GO:0002274	myeloid leukocyte activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43914 ensembl:ENSP00000262629	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-2395436 Reactome:R-MMU-2326808	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Nakano-Yokomizo, T et al. (2011) The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses. J. Exp. Med. 208 1661-71 PubMed GONUTS page
↑ Helming, L et al. (2008) Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Sci Signal 1 ra11 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Kobayashi, M et al. (2015) A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons. Glia 63 1073-82 PubMed GONUTS page
↑ ^4.0 ^4.1 Smith, KM et al. (1998) Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J. Immunol. 161 7-10 PubMed GONUTS page
↑ Humphrey, MB et al. (2004) The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J. Bone Miner. Res. 19 224-34 PubMed GONUTS page
↑ Takahashi, K et al. (2005) Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J. Exp. Med. 201 647-57 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Wakselman, S et al. (2008) Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. J. Neurosci. 28 8138-43 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Roumier, A et al. (2004) Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J. Neurosci. 24 11421-8 PubMed GONUTS page
↑ Zou, W et al. (2008) DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol. Cell 31 422-31 PubMed GONUTS page
↑ Zhao, Y et al. (2018) TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron 97 1023-1031.e7 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Mócsai, A et al. (2006) Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat. Immunol. 7 1326-33 PubMed GONUTS page
↑ Ishida-Kitagawa, N et al. (2012) Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J. Biol. Chem. 287 17493-502 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Barrow, AD et al. (2011) OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J. Clin. Invest. 121 3505-16 PubMed GONUTS page

[PMID:21727189-1] 1.0 ^1.1 Nakano-Yokomizo, T et al. (2011) The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses. J. Exp. Med. 208 1661-71 PubMed GONUTS page

[PMID:18957693-2] Helming, L et al. (2008) Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Sci Signal 1 ra11 PubMed GONUTS page

[PMID:25690660-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Kobayashi, M et al. (2015) A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons. Glia 63 1073-82 PubMed GONUTS page

[PMID:9647200-4] 4.0 ^4.1 Smith, KM et al. (1998) Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J. Immunol. 161 7-10 PubMed GONUTS page

[PMID:14969392-5] Humphrey, MB et al. (2004) The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J. Bone Miner. Res. 19 224-34 PubMed GONUTS page

[PMID:15728241-6] Takahashi, K et al. (2005) Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J. Exp. Med. 201 647-57 PubMed GONUTS page

[PMID:18685038-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Wakselman, S et al. (2008) Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. J. Neurosci. 28 8138-43 PubMed GONUTS page

[PMID:15601948-8] 8.0 ^8.1 ^8.2 ^8.3 Roumier, A et al. (2004) Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J. Neurosci. 24 11421-8 PubMed GONUTS page

[PMID:18691974-9] Zou, W et al. (2008) DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol. Cell 31 422-31 PubMed GONUTS page

[PMID:29518356-10] Zhao, Y et al. (2018) TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron 97 1023-1031.e7 PubMed GONUTS page

[PMID:17086186-11] 11.0 ^11.1 ^11.2 Mócsai, A et al. (2006) Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat. Immunol. 7 1326-33 PubMed GONUTS page

[PMID:22451653-12] Ishida-Kitagawa, N et al. (2012) Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J. Biol. Chem. 287 17493-502 PubMed GONUTS page

[PMID:21841309-13] 13.0 ^13.1 ^13.2 ^13.3 Barrow, AD et al. (2011) OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J. Clin. Invest. 121 3505-16 PubMed GONUTS page

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MOUSE:TYOBP

Contents

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