HUMAN:CAV1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CAV1 (synonyms: CAV)
Protein Name(s)	Caveolin-1
External Links
UniProt	Q03135
EMBL	Z18951 AF095593 AF095591 AF095592 AJ133269 AF125348 BT007143 BC009685 BC082246
CCDS	CCDS55156.1 CCDS5767.1
PIR	S26884
RefSeq	NP_001744.2
UniGene	Hs.74034
ProteinModelPortal	Q03135
BioGrid	107305
DIP	DIP-5960N
IntAct	Q03135
MINT	MINT-152933
STRING	9606.ENSP00000339191
TCDB	8.A.26.1.1
PhosphoSite	Q03135
DMDM	13637934
MaxQB	Q03135
PaxDb	Q03135
PeptideAtlas	Q03135
PRIDE	Q03135
DNASU	857
Ensembl	ENST00000341049 ENST00000393467 ENST00000393468 ENST00000405348 ENST00000614113
GeneID	857
KEGG	hsa:857
UCSC	uc003vif.2
CTD	857
GeneCards	GC07P116164
HGNC	HGNC:1527
HPA	CAB003791
MIM	601047 606721 612526 615343
neXtProt	NX_Q03135
Orphanet	528 220393 275777 220402
PharmGKB	PA26107
eggNOG	NOG86001
GeneTree	ENSGT00390000014924
HOVERGEN	HBG003422
InParanoid	Q03135
KO	K06278
OMA	VHTFCDP
OrthoDB	EOG7V1FSD
PhylomeDB	Q03135
TreeFam	TF315736
Reactome	REACT_12477 REACT_12541 REACT_12560 REACT_200610 REACT_228016 REACT_494
SignaLink	Q03135
ChiTaRS	CAV1
GeneWiki	Caveolin_1
GenomeRNAi	857
NextBio	3556
PRO	PR:Q03135
Proteomes	UP000005640
Bgee	Q03135
CleanEx	HS_CAV1
ExpressionAtlas	Q03135
Genevestigator	Q03135
GO	GO:0002080 GO:0016324 GO:0016323 GO:0005901 GO:0005938 GO:0005929 GO:0031410 GO:0030666 GO:0005783 GO:0005768 GO:0005925 GO:0000139 GO:0005887 GO:0005622 GO:0005811 GO:0045121 GO:0048471 GO:0005886 GO:0043234 GO:0015485 GO:0019899 GO:0050998 GO:0005113 GO:0016504 GO:0032947 GO:0005102 GO:0005198 GO:0001525 GO:0097190 GO:0007596 GO:0055074 GO:0006816 GO:0070836 GO:0072584 GO:0006874 GO:0071455 GO:0009267 GO:0042632 GO:0030301 GO:0051480 GO:0000188 GO:0007595 GO:0050900 GO:0019915 GO:0032507 GO:0030879 GO:0060056 GO:0000165 GO:0051899 GO:2000811 GO:0030514 GO:0090090 GO:0001960 GO:0001937 GO:0030857 GO:0046426 GO:0043409 GO:0045019 GO:0051001 GO:0033137 GO:0048550 GO:0032091 GO:0031397 GO:0000122 GO:0042524 GO:0033484 GO:0046209 GO:0010524 GO:0090263 GO:2001238 GO:2001244 GO:0048554 GO:0033138 GO:0045907 GO:0051260 GO:0008104 GO:2000286 GO:0030193 GO:0019217 GO:0050999 GO:0052547 GO:0006940 GO:0003057 GO:0051592 GO:0043627 GO:0001666 GO:0002931 GO:0032570 GO:0007519 GO:0044281 GO:0031295 GO:0006641 GO:0001570 GO:0042310 GO:0016050 GO:0016032
InterPro	IPR001612 IPR015504 IPR018361
PANTHER	PTHR10844 PTHR10844:SF5
Pfam	PF01146
PROSITE	PS01210

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019065	receptor-mediated endocytosis of virus by host	PMID:21047970^[1]	ECO:0000316		UniProtKB:P51636	P		Fig. 2EFG Part of the caveola/lipid raft-mediated entry pathway	complete CACAO 2436
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:23319823^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:15734843^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:21109942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:21822278^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:19525939^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:24625804^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
involved_in	GO:1900027	regulation of ruffle assembly	PMID:24625804^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:24625804^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000535	regulation of entry of bacterium into host cell	PMID:24625804^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	PMID:24625804^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:24089527^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P55072) has_regulation_target:(UniProtKB:Q9BUN8)	Seeded From UniProt	complete
colocalizes_with	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	PMID:24089527^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55072	C		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:24089527^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55072	F		Seeded From UniProt	complete
involved_in	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process	PMID:24089527^[8]	ECO:0000305	curator inference used in manual assertion	GO:0005515 GO:0031398 GO:0034098	P	has_input:(UniProtKB:P35354)	Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:24089527^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P35354)	Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:25893292^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:25893292^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:25893292^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:25556234^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	PMID:25204797^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0060355	positive regulation of cell adhesion molecule production	PMID:25204797^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115) happens_during:(GO:0034138) has_input:(UniProtKB:P19320)	Seeded From UniProt	complete
involved_in	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	PMID:25204797^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:25204797^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0019065	receptor-mediated endocytosis of virus by host cell	PMID:21047970^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P51636	P		Seeded From UniProt	complete
involved_in	GO:1903598	positive regulation of gap junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P	occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0098911	regulation of ventricular cardiac muscle cell action potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0086098	angiotensin-activated signaling pathway involved in heart process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P	occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P	occurs_in:(CL:1001567)	Seeded From UniProt	complete
colocalizes_with	GO:0005925	focal adhesion	PMID:12091389^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:2000008)	Seeded From UniProt	complete
involved_in	GO:1903361	protein localization to basolateral plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33724	P		Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33724	P	occurs_in:(GO:0016323)	Seeded From UniProt	complete
involved_in	GO:0044860	protein localization to plasma membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33724	P	occurs_in:(GO:0016323)	Seeded From UniProt	complete
involved_in	GO:0016050	vesicle organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33724	P		Seeded From UniProt	complete
involved_in	GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction	PMID:18923542^[13]	ECO:0000305	curator inference used in manual assertion	GO:1903609	P		Seeded From UniProt	complete
involved_in	GO:1901380	negative regulation of potassium ion transmembrane transport	PMID:18923542^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903609	negative regulation of inward rectifier potassium channel activity	PMID:18923542^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q12809)	Seeded From UniProt	complete
involved_in	GO:0098903	regulation of membrane repolarization during action potential	PMID:18923542^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070320	inward rectifier potassium channel inhibitor activity	PMID:18923542^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q12809)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:18923542^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12809	F		Seeded From UniProt	complete
involved_in	GO:0061099	negative regulation of protein tyrosine kinase activity	PMID:25006397^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P12931)	Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	PMID:25006397^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49817	P	occurs_in:(CL:1001567)	Seeded From UniProt	complete
involved_in	GO:1900085	negative regulation of peptidyl-tyrosine autophosphorylation	PMID:25006397^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P12931)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25006397^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:25006397^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:14559243^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048550	negative regulation of pinocytosis	PMID:23583380^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway	PMID:16890161^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:16890161^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	PMID:12633858^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060056	mammary gland involution	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0052547	regulation of peptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:19052258^[20]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:19052258^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	PMID:12852865^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29474	F		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	C		Seeded From UniProt	complete
involved_in	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:17010968^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045019	negative regulation of nitric oxide biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0043409	negative regulation of MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0033484	nitric oxide homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:18081315^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P51636)	Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	PMID:18081315^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032507	maintenance of protein location in cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41350	P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:16890161^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0030857	negative regulation of epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0030193	regulation of blood coagulation	PMID:17848177^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0019217	regulation of fatty acid metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
enables	GO:0016504	peptidase activator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	F		Seeded From UniProt	complete
involved_in	GO:0010524	positive regulation of calcium ion transport into cytosol	PMID:19052258^[20]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0006940	regulation of smooth muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:18081315^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:15703204^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001296) part_of:(CL:0000192)	Seeded From UniProt	complete
enables	GO:0005113	patched binding	PMID:11278759^[26]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:16890161^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75581	F		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0000188	inactivation of MAPK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:11294831^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:11294831^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	PMID:11294831^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:21382479^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PMID:21382479^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	PMID:22277751^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:21382479^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0072584	caveolin-mediated endocytosis	PMID:19931615^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071455	cellular response to hyperoxia	PMID:21382479^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:19931615^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000030)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:23262137^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:21382479^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:19931615^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000030)	Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:22277751^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	PMID:17287217^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20122998^[33]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16647	F		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:15219854^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23262137^[31]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:20682791^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49817	P		Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107570 PANTHER:PTN000851526 UniProtKB:P51636 UniProtKB:P56539 UniProtKB:Q03135	P		Seeded From UniProt	complete
involved_in	GO:0061099	negative regulation of protein tyrosine kinase activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 UniProtKB:Q03135	P		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107571 PANTHER:PTN000851526 RGD:2281 UniProtKB:P56539	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 RGD:2280 UniProtKB:Q03135	C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000090213 RGD:2280 UniProtKB:Q03135	F		Seeded From UniProt	complete
colocalizes_with	GO:0042383	sarcolemma	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107570 PANTHER:PTN000090155 RGD:2281 UniProtKB:P56539 UniProtKB:P79132 UniProtKB:Q2KI43 UniProtKB:Q66WT7	C		Seeded From UniProt	complete
colocalizes_with	GO:0032991	protein-containing complex	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107571 PANTHER:PTN000090155 RGD:2280 RGD:2281 RGD:620348 UniProtKB:P51636 UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000090213 RGD:2280 UniProtKB:Q03135	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000090155 RGD:2281	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 UniProtKB:Q03135	F		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 RGD:2280	P		Seeded From UniProt	complete
colocalizes_with	GO:0005925	focal adhesion	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107571 PANTHER:PTN000090155 RGD:2280 UniProtKB:P51636 UniProtKB:Q03135	C		Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107570 PANTHER:PTN000851526 RGD:2280 RGD:2281 RGD:620348 UniProtKB:P33724 UniProtKB:P35431 UniProtKB:P51636 UniProtKB:P79132 UniProtKB:Q03135 UniProtKB:Q2KI43 UniProtKB:Q66WT7 UniProtKB:Q6RVA9	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000851526 UniProtKB:P51636 WB:WBGene00000301	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 RGD:2280	C		Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000851526 RGD:2280 RGD:2281 RGD:620348	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000851526 UniProtKB:P33724 UniProtKB:Q03135	F		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 RGD:2280	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:12388746^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:24013648^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	PMID:12388746^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:22792322^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:24013648^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:17982011^[40]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010952	positive regulation of peptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016504	P		Seeded From UniProt	complete
involved_in	GO:0010952	positive regulation of peptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016504	P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:1903598	positive regulation of gap junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:1900085	negative regulation of peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0098911	regulation of ventricular cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0086098	angiotensin-activated signaling pathway involved in heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0061099	negative regulation of protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0060546	negative regulation of necroptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	F		Seeded From UniProt	complete
involved_in	GO:0060056	mammary gland involution	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0052547	regulation of peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0051001	negative regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	F		Seeded From UniProt	complete
involved_in	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
involved_in	GO:0045019	negative regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0043409	negative regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0033484	nitric oxide homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0030857	negative regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	F		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	F		Seeded From UniProt	complete
involved_in	GO:0019217	regulation of fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
enables	GO:0016504	peptidase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0010608	posttranscriptional regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0010524	positive regulation of calcium ion transport into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0006940	regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
involved_in	GO:0003057	regulation of the force of heart contraction by chemical signal	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
part_of	GO:0002080	acrosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	C		Seeded From UniProt	complete
involved_in	GO:0002026	regulation of the force of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0001960	negative regulation of cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0000188	inactivation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49817 ensembl:ENSMUSP00000007799	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015504	C		Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001612 InterPro:IPR015504	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:16904002^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:16904002^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:15657086^[42]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	PMID:15657086^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:15657086^[42]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:15657086^[42]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:24089527^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	PMID:19052258^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:11294831^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030301	cholesterol transport	PMID:11294831^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:11294831^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1904886	beta-catenin destruction complex disassembly	Reactome:R-HSA-4641262	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	Reactome:R-HSA-203641 Reactome:R-HSA-203615	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	Reactome:R-HSA-5368596	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-203625	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-9624985 Reactome:R-HSA-5368596 Reactome:R-HSA-203716 Reactome:R-HSA-203712 Reactome:R-HSA-203662 Reactome:R-HSA-203625 Reactome:R-HSA-203565 Reactome:R-HSA-202144 Reactome:R-HSA-202129 Reactome:R-HSA-202110	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	Reactome:R-HSA-203712 Reactome:R-HSA-202144	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-204549	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0035	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hunt, CL et al. (2011) The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J. Virol. 85 334-47 PubMed GONUTS page
↑ Gong, H et al. (2013) Downregulation of miR-138 sustains NF-κB activation and promotes lipid raft formation in esophageal squamous cell carcinoma. Clin. Cancer Res. 19 1083-93 PubMed GONUTS page
↑ Cohen, AW et al. (2005) Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue. Diabetes 54 679-86 PubMed GONUTS page
↑ Nohata, N et al. (2011) Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma. Int. J. Oncol. 38 209-17 PubMed GONUTS page
↑ Ritz, D et al. (2011) Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol. 13 1116-23 PubMed GONUTS page
↑ Hansen, CG et al. (2009) SDPR induces membrane curvature and functions in the formation of caveolae. Nat. Cell Biol. 11 807-14 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Lim, JS et al. (2014) Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization. J. Infect. Dis. 210 793-802 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Chen, SF et al. (2013) Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. J. Biol. Chem. 288 33462-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page
↑ Kipper, S et al. (2015) New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. Mol. Cell Proteomics 14 532-43 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Fork, C et al. (2014) Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res. Cardiol. 109 439 PubMed GONUTS page
↑ Lee, H et al. (2002) Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. J. Biol. Chem. 277 34556-67 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Lin, J et al. (2008) The regulation of the cardiac potassium channel (HERG) by caveolin-1. Biochem. Cell Biol. 86 405-15 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Bakhshi, FR et al. (2013) Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm Circ 3 816-30 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Hood, JL et al. (2003) Association of the calpain/calpastatin network with subcellular organelles. Biochem. Biophys. Res. Commun. 310 1200-12 PubMed GONUTS page
↑ Singh, RD et al. (2013) Prominin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosis. Biochem. Biophys. Res. Commun. 434 466-72 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Yamamoto, H et al. (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev. Cell 11 213-23 PubMed GONUTS page
↑ Lahtinen, U et al. (2003) Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. FEBS Lett. 538 85-8 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Sundivakkam, PC et al. (2009) Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Am. J. Physiol., Cell Physiol. 296 C403-13 PubMed GONUTS page
↑ Linton, EA et al. (2003) Caveolae and caveolin-1 in human term villous trophoblast. Placenta 24 745-57 PubMed GONUTS page
↑ Tellier, E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp. Cell Res. 312 3969-80 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Sowa, G et al. (2008) Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. Biochemistry 47 101-11 PubMed GONUTS page
↑ Banfi, C et al. (2007) Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J. Thromb. Haemost. 5 2437-44 PubMed GONUTS page
↑ Brainard, AM et al. (2005) Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current. Am. J. Physiol., Cell Physiol. 289 C49-57 PubMed GONUTS page
↑ Karpen, HE et al. (2001) The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J. Biol. Chem. 276 19503-11 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 de Marco, MC et al. (2001) BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells. J. Biol. Chem. 276 23009-17 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 Zhang, M et al. (2011) Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis. Free Radic. Biol. Med. 50 1252-62 PubMed GONUTS page
↑ ^29.0 ^29.1 Chunhacha, P et al. (2012) Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells. Am. J. Physiol., Cell Physiol. 302 C1284-92 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Lanciotti, A et al. (2010) MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation. Neurobiol. Dis. 37 581-95 PubMed GONUTS page
↑ ^31.0 ^31.1 Tiwari, A et al. (2013) The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling. Am. J. Physiol. Heart Circ. Physiol. 304 H687-96 PubMed GONUTS page
↑ Ohnuma, K et al. (2007) Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. J. Biol. Chem. 282 10117-31 PubMed GONUTS page
↑ Cathcart, MC et al. (2010) The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer. Biochim. Biophys. Acta 1805 153-66 PubMed GONUTS page
↑ Vainonen, JP et al. (2004) N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes. Biochem. Biophys. Res. Commun. 320 480-6 PubMed GONUTS page
↑ Gorbea, C et al. (2010) A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J. Biol. Chem. 285 31616-33 PubMed GONUTS page
↑ ^36.00 ^36.01 ^36.02 ^36.03 ^36.04 ^36.05 ^36.06 ^36.07 ^36.08 ^36.09 ^36.10 ^36.11 ^36.12 ^36.13 ^36.14 ^36.15 ^36.16 ^36.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^37.0 ^37.1 Park, DS et al. (2002) Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Mol. Biol. Cell 13 3416-30 PubMed GONUTS page
↑ ^38.0 ^38.1 Ludwig, A et al. (2013) Molecular composition and ultrastructure of the caveolar coat complex. PLoS Biol. 11 e1001640 PubMed GONUTS page
↑ Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page
↑ Volonte, D et al. (2008) Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis. Am. J. Physiol. Heart Circ. Physiol. 294 H392-401 PubMed GONUTS page
↑ ^41.0 ^41.1 Krasteva, G et al. (2006) Caveolin-1 and -2 in airway epithelium: expression and in situ association as detected by FRET-CLSM. Respir. Res. 7 108 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 ^42.3 Nohe, A et al. (2005) Dynamics and interaction of caveolin-1 isoforms with BMP-receptors. J. Cell. Sci. 118 643-50 PubMed GONUTS page

[PMID:21047970-1] 1.0 ^1.1 Hunt, CL et al. (2011) The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J. Virol. 85 334-47 PubMed GONUTS page

[PMID:23319823-2] Gong, H et al. (2013) Downregulation of miR-138 sustains NF-κB activation and promotes lipid raft formation in esophageal squamous cell carcinoma. Clin. Cancer Res. 19 1083-93 PubMed GONUTS page

[PMID:15734843-3] Cohen, AW et al. (2005) Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue. Diabetes 54 679-86 PubMed GONUTS page

[PMID:21109942-4] Nohata, N et al. (2011) Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma. Int. J. Oncol. 38 209-17 PubMed GONUTS page

[PMID:21822278-5] Ritz, D et al. (2011) Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol. 13 1116-23 PubMed GONUTS page

[PMID:19525939-6] Hansen, CG et al. (2009) SDPR induces membrane curvature and functions in the formation of caveolae. Nat. Cell Biol. 11 807-14 PubMed GONUTS page

[PMID:24625804-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Lim, JS et al. (2014) Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization. J. Infect. Dis. 210 793-802 PubMed GONUTS page

[PMID:24089527-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Chen, SF et al. (2013) Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. J. Biol. Chem. 288 33462-9 PubMed GONUTS page

[PMID:25893292-9] 9.0 ^9.1 ^9.2 Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page

[PMID:25556234-10] Kipper, S et al. (2015) New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. Mol. Cell Proteomics 14 532-43 PubMed GONUTS page

[PMID:25204797-11] 11.0 ^11.1 ^11.2 ^11.3 Fork, C et al. (2014) Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res. Cardiol. 109 439 PubMed GONUTS page

[PMID:12091389-12] Lee, H et al. (2002) Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. J. Biol. Chem. 277 34556-67 PubMed GONUTS page

[PMID:18923542-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Lin, J et al. (2008) The regulation of the cardiac potassium channel (HERG) by caveolin-1. Biochem. Cell Biol. 86 405-15 PubMed GONUTS page

[PMID:25006397-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Bakhshi, FR et al. (2013) Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm Circ 3 816-30 PubMed GONUTS page

[PMID:21423176-15] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:14559243-16] Hood, JL et al. (2003) Association of the calpain/calpastatin network with subcellular organelles. Biochem. Biophys. Res. Commun. 310 1200-12 PubMed GONUTS page

[PMID:23583380-17] Singh, RD et al. (2013) Prominin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosis. Biochem. Biophys. Res. Commun. 434 466-72 PubMed GONUTS page

[PMID:16890161-18] 18.0 ^18.1 ^18.2 ^18.3 Yamamoto, H et al. (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev. Cell 11 213-23 PubMed GONUTS page

[PMID:12633858-19] Lahtinen, U et al. (2003) Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. FEBS Lett. 538 85-8 PubMed GONUTS page

[PMID:19052258-20] 20.0 ^20.1 ^20.2 ^20.3 Sundivakkam, PC et al. (2009) Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Am. J. Physiol., Cell Physiol. 296 C403-13 PubMed GONUTS page

[PMID:12852865-21] Linton, EA et al. (2003) Caveolae and caveolin-1 in human term villous trophoblast. Placenta 24 745-57 PubMed GONUTS page

[PMID:17010968-22] Tellier, E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp. Cell Res. 312 3969-80 PubMed GONUTS page

[PMID:18081315-23] 23.0 ^23.1 ^23.2 Sowa, G et al. (2008) Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. Biochemistry 47 101-11 PubMed GONUTS page

[PMID:17848177-24] Banfi, C et al. (2007) Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J. Thromb. Haemost. 5 2437-44 PubMed GONUTS page

[PMID:15703204-25] Brainard, AM et al. (2005) Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current. Am. J. Physiol., Cell Physiol. 289 C49-57 PubMed GONUTS page

[PMID:11278759-26] Karpen, HE et al. (2001) The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J. Biol. Chem. 276 19503-11 PubMed GONUTS page

[PMID:11294831-27] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 de Marco, MC et al. (2001) BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells. J. Biol. Chem. 276 23009-17 PubMed GONUTS page

[PMID:21382479-28] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 Zhang, M et al. (2011) Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis. Free Radic. Biol. Med. 50 1252-62 PubMed GONUTS page

[PMID:22277751-29] 29.0 ^29.1 Chunhacha, P et al. (2012) Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells. Am. J. Physiol., Cell Physiol. 302 C1284-92 PubMed GONUTS page

[PMID:19931615-30] 30.0 ^30.1 ^30.2 Lanciotti, A et al. (2010) MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation. Neurobiol. Dis. 37 581-95 PubMed GONUTS page

[PMID:23262137-31] 31.0 ^31.1 Tiwari, A et al. (2013) The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling. Am. J. Physiol. Heart Circ. Physiol. 304 H687-96 PubMed GONUTS page

[PMID:17287217-32] Ohnuma, K et al. (2007) Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. J. Biol. Chem. 282 10117-31 PubMed GONUTS page

[PMID:20122998-33] Cathcart, MC et al. (2010) The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer. Biochim. Biophys. Acta 1805 153-66 PubMed GONUTS page

[PMID:15219854-34] Vainonen, JP et al. (2004) N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes. Biochem. Biophys. Res. Commun. 320 480-6 PubMed GONUTS page

[PMID:20682791-35] Gorbea, C et al. (2010) A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J. Biol. Chem. 285 31616-33 PubMed GONUTS page

[PMID:21873635-36] 36.00 ^36.01 ^36.02 ^36.03 ^36.04 ^36.05 ^36.06 ^36.07 ^36.08 ^36.09 ^36.10 ^36.11 ^36.12 ^36.13 ^36.14 ^36.15 ^36.16 ^36.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12388746-37] 37.0 ^37.1 Park, DS et al. (2002) Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Mol. Biol. Cell 13 3416-30 PubMed GONUTS page

[PMID:24013648-38] 38.0 ^38.1 Ludwig, A et al. (2013) Molecular composition and ultrastructure of the caveolar coat complex. PLoS Biol. 11 e1001640 PubMed GONUTS page

[PMID:22792322-39] Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page

[PMID:17982011-40] Volonte, D et al. (2008) Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis. Am. J. Physiol. Heart Circ. Physiol. 294 H392-401 PubMed GONUTS page

[PMID:16904002-41] 41.0 ^41.1 Krasteva, G et al. (2006) Caveolin-1 and -2 in airway epithelium: expression and in situ association as detected by FRET-CLSM. Respir. Res. 7 108 PubMed GONUTS page

[PMID:15657086-42] 42.0 ^42.1 ^42.2 ^42.3 Nohe, A et al. (2005) Dynamics and interaction of caveolin-1 isoforms with BMP-receptors. J. Cell. Sci. 118 643-50 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

HUMAN:CAV1

Contents

Annotations

Notes

References

a

b

c

e

f

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools