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PMID:12633858

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Citation

Lahtinen, U, Honsho, M, Parton, RG, Simons, K and Verkade, P (2003) Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. FEBS Lett. 538:85-8

Abstract

Caveolins have been identified as key components of caveolae, specialized cholesterol-enriched raft domains visible as small flask-shaped invaginations of the plasma membrane. In polarized MDCK cells caveolin-1 and -2 are found together on basolateral caveolae whereas the apical membrane, where only caveolin-1 is present, lacks caveolae. Expression of a caveolin mutant prevented the formation of the large caveolin-1/-2 hetero-oligomeric complexes, and led to intracellular retention of caveolin-2 and disappearance of caveolae from the basolateral membrane. Correspondingly, in MDCK cells over-expressing caveolin-2 the basolateral membrane exhibited an increased number of caveolae. These results indicate the involvement of caveolin-2 in caveolar biogenesis.

Links

PubMed

Keywords

Animals; Caveolae/physiology; Caveolae/ultrastructure; Caveolin 2; Caveolins/physiology; Dogs; Electrophoresis, Gel, Two-Dimensional; Fluorescent Antibody Technique; Microscopy, Electron

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

PAPAN:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

FELCA:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

ECHTE:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

CANLF:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

ATEAB:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

AOTNA:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

MUNRE:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

MUSPF:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

NEONE:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

DASNO:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

SAIBB:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

SHEEP:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

MUNMU:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

ATEGE:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

RABIT:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

LOXAF:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

CHLAE:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

RHIFE:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

RAT:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

PONAB:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

GORGO:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

EULMM:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

DIDVI:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

MICMU:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

HORSE:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

PLEMO:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

CARPS:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

PIG:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

PANTR:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

CALJA:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

OTOGA:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

BOVIN:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

MOUSE:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P51636

P

Seeded From UniProt

complete

HUMAN:CAV1

involved_in

GO:0070836: caveola assembly

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CAV2

involved_in

GO:0070836: caveola assembly

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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