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DROME:RPR

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) rpr
Protein Name(s) Cell death protein rpr

Protein reaper

External Links
UniProt Q24475
EMBL L31631
AE014296
BT023284
BT029413
RefSeq NP_524138.1
UniGene Dm.2529
BioGrid 65299
DIP DIP-21897N
IntAct Q24475
MINT MINT-937693
PRIDE Q24475
EnsemblMetazoa FBtr0075120
GeneID 40015
KEGG dme:Dmel_CG4319
CTD 40015
FlyBase FBgn0011706
eggNOG NOG304255
InParanoid Q24475
OMA QWRFLAT
OrthoDB EOG7BS4DC
PhylomeDB Q24475
GenomeRNAi 40015
NextBio 816567
Proteomes UP000000803
Bgee Q24475
GO GO:0005737
GO:0005741
GO:0005739
GO:0005543
GO:0042803
GO:0031625
GO:0006915
GO:0097190
GO:0008219
GO:0071480
GO:0035072
GO:0048803
GO:0008630
GO:0008627
GO:0035193
GO:0035096
GO:0043524
GO:0031398
GO:2000060
GO:0012501
GO:0042176
GO:0035071

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

PMID:10675328[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11818065[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021769[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021771[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005543

phospholipid binding

PMID:17998202[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:10511707[6]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:12917412[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005741

mitochondrial outer membrane

PMID:17998202[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006915

apoptotic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10910336[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:11818065[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:11880355[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:17998202[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:20837774[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:8171319[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:8948586[12]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:8948586[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:9294184[13]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008219

cell death

PMID:16887178[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008627

intrinsic apoptotic signaling pathway in response to osmotic stress

PMID:9751729[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:18688282[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:12006672[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:12072176[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:16168982[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031398

positive regulation of protein ubiquitination

PMID:12021769[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031624

ubiquitin conjugating enzyme binding

PMID:21886178[20]

IPI: Inferred from Physical Interaction

FB:FBgn0266717

F

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

PMID:12021769[3]

IPI: Inferred from Physical Interaction

FB:FBgn0260635

F

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

PMID:9294184[13]

IPI: Inferred from Physical Interaction

FB:FBgn0015247

F

Seeded From UniProt

complete

GO:0035071

salivary gland cell autophagic cell death

PMID:15150408[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0003997

P

Seeded From UniProt

complete

GO:0035072

ecdysone-mediated induction of salivary gland cell autophagic cell death

PMID:10882130[22]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0035096

larval midgut cell programmed cell death

PMID:15150408[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0003997

P

Seeded From UniProt

complete

GO:0035193

larval central nervous system remodeling

PMID:10821983[23]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042176

regulation of protein catabolic process

PMID:17998202[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042803

protein homodimerization activity

PMID:20837774[10]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0043524

negative regulation of neuron apoptotic process

PMID:21558369[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048803

imaginal disc-derived male genitalia morphogenesis

PMID:21389055[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071479

cellular response to ionizing radiation

PMID:11818065[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0071480

cellular response to gamma radiation

PMID:24265704[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:10481910[27]

IGI: Inferred from Genetic Interaction

FB:FBgn0260635

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:8628996[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:9814703[29]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000060

positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

PMID:12021769[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0011217

P

Seeded From UniProt

complete

GO:2001056

positive regulation of cysteine-type endopeptidase activity

PMID:17557079[30]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:2001272

positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

PMID:15107838[31]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

NOT

GO:0045476

nurse cell apoptotic process

PMID:11139280[32]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

NOT

GO:0045476

nurse cell apoptotic process

PMID:12072176[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

colocalizes_with

GO:0000502

proteasome complex

PMID:22036573[33]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Goyal, L et al. (2000) Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19 589-97 PubMed GONUTS page
  2. 2.0 2.1 2.2 Christich, A et al. (2002) The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Curr. Biol. 12 137-40 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Ryoo, HD et al. (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell Biol. 4 432-8 PubMed GONUTS page
  4. Wilson, R et al. (2002) The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat. Cell Biol. 4 445-50 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Freel, CD et al. (2008) Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions. J. Biol. Chem. 283 367-79 PubMed GONUTS page
  6. Abrams, JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol. 9 435-40 PubMed GONUTS page
  7. Olson, MR et al. (2003) A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. J. Biol. Chem. 278 44758-68 PubMed GONUTS page
  8. De Laurenzi, V & Melino, G (2000) Apoptosis. The little devil of death. Nature 406 135-6 PubMed GONUTS page
  9. Peterson, C et al. (2002) reaper is required for neuroblast apoptosis during Drosophila development. Development 129 1467-76 PubMed GONUTS page
  10. 10.0 10.1 Sandu, C et al. (2010) Drosophila IAP antagonists form multimeric complexes to promote cell death. J. Cell Biol. 190 1039-52 PubMed GONUTS page
  11. White, K et al. (1994) Genetic control of programmed cell death in Drosophila. Science 264 677-83 PubMed GONUTS page
  12. 12.0 12.1 Nordstrom, W et al. (1996) Activation of the reaper gene during ectopic cell killing in Drosophila. Dev. Biol. 180 213-26 PubMed GONUTS page
  13. 13.0 13.1 Vucic, D et al. (1997) Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs). Proc. Natl. Acad. Sci. U.S.A. 94 10183-8 PubMed GONUTS page
  14. Kuranaga, E et al. (2006) Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 126 583-96 PubMed GONUTS page
  15. Avdonin, V et al. (1998) Apoptotic proteins Reaper and Grim induce stable inactivation in voltage-gated K+ channels. Proc. Natl. Acad. Sci. U.S.A. 95 11703-8 PubMed GONUTS page
  16. Moon, NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 4 e1000153 PubMed GONUTS page
  17. Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page
  18. 18.0 18.1 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
  19. Rodriguez Moncalvo, VG & Campos, AR (2005) Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev. Biol. 286 549-58 PubMed GONUTS page
  20. Domingues, C & Ryoo, HD (2012) Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER. Cell Death Differ. 19 470-7 PubMed GONUTS page
  21. 21.0 21.1 Yin, VP & Thummel, CS (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 8022-7 PubMed GONUTS page
  22. Jiang, C et al. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Mol. Cell 5 445-55 PubMed GONUTS page
  23. Tissot, M & Stocker, RF (2000) Metamorphosis in drosophila and other insects: the fate of neurons throughout the stages. Prog. Neurobiol. 62 89-111 PubMed GONUTS page
  24. Tan, Y et al. (2011) Coordinated expression of cell death genes regulates neuroblast apoptosis. Development 138 2197-206 PubMed GONUTS page
  25. Kuranaga, E et al. (2011) Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia. Development 138 1493-9 PubMed GONUTS page
  26. Zhang, C et al. (2013) Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage. PLoS ONE 8 e78652 PubMed GONUTS page
  27. Wang, SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98 453-63 PubMed GONUTS page
  28. White, K et al. (1996) Cell killing by the Drosophila gene reaper. Science 271 805-7 PubMed GONUTS page
  29. Kurada, P & White, K (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95 319-29 PubMed GONUTS page
  30. Challa, M et al. (2007) Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 26 3144-56 PubMed GONUTS page
  31. Yan, N et al. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat. Struct. Mol. Biol. 11 420-8 PubMed GONUTS page
  32. Buszczak, M & Cooley, L (2000) Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ. 7 1071-4 PubMed GONUTS page
  33. Guruharsha, KG et al. (2011) A protein complex network of Drosophila melanogaster. Cell 147 690-703 PubMed GONUTS page