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DROME:RPR
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | rpr | |
| Protein Name(s) | Cell death protein rpr
Protein reaper | |
| External Links | ||
| UniProt | Q24475 | |
| EMBL | L31631 AE014296 BT023284 BT029413 | |
| RefSeq | NP_524138.1 | |
| UniGene | Dm.2529 | |
| BioGrid | 65299 | |
| DIP | DIP-21897N | |
| IntAct | Q24475 | |
| MINT | MINT-937693 | |
| PRIDE | Q24475 | |
| EnsemblMetazoa | FBtr0075120 | |
| GeneID | 40015 | |
| KEGG | dme:Dmel_CG4319 | |
| CTD | 40015 | |
| FlyBase | FBgn0011706 | |
| eggNOG | NOG304255 | |
| InParanoid | Q24475 | |
| OMA | QWRFLAT | |
| OrthoDB | EOG7BS4DC | |
| PhylomeDB | Q24475 | |
| GenomeRNAi | 40015 | |
| NextBio | 816567 | |
| Proteomes | UP000000803 | |
| Bgee | Q24475 | |
| GO | GO:0005737 GO:0005741 GO:0005739 GO:0005543 GO:0042803 GO:0031625 GO:0006915 GO:0097190 GO:0008219 GO:0071480 GO:0035072 GO:0048803 GO:0008630 GO:0008627 GO:0035193 GO:0035096 GO:0043524 GO:0031398 GO:2000060 GO:0012501 GO:0042176 GO:0035071 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:2001056 |
positive regulation of cysteine-type endopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008219 |
cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0012501 |
programmed cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035096 |
larval midgut cell programmed cell death |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0003997 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035071 |
salivary gland cell autophagic cell death |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0003997 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2001272 |
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
DOI:10.1016/S0168-9525(02)02778-6 |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000060 |
positive regulation of ubiquitin-dependent protein catabolic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0011217 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
FB:FBgn0260635 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071479 |
cellular response to ionizing radiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035072 |
ecdysone-mediated induction of salivary gland cell autophagic cell death |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097190 |
apoptotic signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0260635 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097190 |
apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
FB:FBgn0015247 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097190 |
apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071480 |
cellular response to gamma radiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031624 |
ubiquitin conjugating enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
FB:FBgn0266717 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048803 |
imaginal disc-derived male genitalia morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005543 |
phospholipid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042176 |
regulation of protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0012501 |
programmed cell death |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
NOT|involved_in |
GO:0045476 |
nurse cell apoptotic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035193 |
larval central nervous system remodeling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008627 |
intrinsic apoptotic signaling pathway in response to osmotic stress |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Challa, M et al. (2007) Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 26 3144-56 PubMed GONUTS page
- ↑ Kuranaga, E et al. (2006) Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 126 583-96 PubMed GONUTS page
- ↑ Rodriguez Moncalvo, VG & Campos, AR (2005) Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev. Biol. 286 549-58 PubMed GONUTS page
- ↑ 4.0 4.1 Yin, VP & Thummel, CS (2004) A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 8022-7 PubMed GONUTS page
- ↑ Yan, N et al. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat. Struct. Mol. Biol. 11 420-8 PubMed GONUTS page
- ↑ Olson, MR et al. (2003) A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. J. Biol. Chem. 278 44758-68 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Ryoo, HD et al. (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell Biol. 4 432-8 PubMed GONUTS page
- ↑ Peterson, C et al. (2002) reaper is required for neuroblast apoptosis during Drosophila development. Development 129 1467-76 PubMed GONUTS page
- ↑ 9.0 9.1 Christich, A et al. (2002) The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Curr. Biol. 12 137-40 PubMed GONUTS page
- ↑ Jiang, C et al. (2000) A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Mol. Cell 5 445-55 PubMed GONUTS page
- ↑ Wang, SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98 453-63 PubMed GONUTS page
- ↑ Kurada, P & White, K (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95 319-29 PubMed GONUTS page
- ↑ 13.0 13.1 Vucic, D et al. (1997) Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs). Proc. Natl. Acad. Sci. U.S.A. 94 10183-8 PubMed GONUTS page
- ↑ 14.0 14.1 Nordstrom, W et al. (1996) Activation of the reaper gene during ectopic cell killing in Drosophila. Dev. Biol. 180 213-26 PubMed GONUTS page
- ↑ White, K et al. (1996) Cell killing by the Drosophila gene reaper. Science 271 805-7 PubMed GONUTS page
- ↑ White, K et al. (1994) Genetic control of programmed cell death in Drosophila. Science 264 677-83 PubMed GONUTS page
- ↑ Zhang, C et al. (2013) Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage. PLoS ONE 8 e78652 PubMed GONUTS page
- ↑ Domingues, C & Ryoo, HD (2012) Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER. Cell Death Differ. 19 470-7 PubMed GONUTS page
- ↑ Tan, Y et al. (2011) Coordinated expression of cell death genes regulates neuroblast apoptosis. Development 138 2197-206 PubMed GONUTS page
- ↑ Kuranaga, E et al. (2011) Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia. Development 138 1493-9 PubMed GONUTS page
- ↑ 21.0 21.1 Sandu, C et al. (2010) Drosophila IAP antagonists form multimeric complexes to promote cell death. J. Cell Biol. 190 1039-52 PubMed GONUTS page
- ↑ Moon, NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 4 e1000153 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 Freel, CD et al. (2008) Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions. J. Biol. Chem. 283 367-79 PubMed GONUTS page
- ↑ 24.0 24.1 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
- ↑ Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page
- ↑ Buszczak, M & Cooley, L (2000) Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ. 7 1071-4 PubMed GONUTS page
- ↑ De Laurenzi, V & Melino, G (2000) Apoptosis. The little devil of death. Nature 406 135-6 PubMed GONUTS page
- ↑ Tissot, M & Stocker, RF (2000) Metamorphosis in drosophila and other insects: the fate of neurons throughout the stages. Prog. Neurobiol. 62 89-111 PubMed GONUTS page
- ↑ Abrams, JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol. 9 435-40 PubMed GONUTS page
- ↑ Avdonin, V et al. (1998) Apoptotic proteins Reaper and Grim induce stable inactivation in voltage-gated K+ channels. Proc. Natl. Acad. Sci. U.S.A. 95 11703-8 PubMed GONUTS page
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- GO:0035072 ! obsolete ecdysone-mediated induction of salivary gland cell autophagic cell death
- GO:2001056 ! obsolete positive regulation of cysteine-type endopeptidase activity
- GO:2001272 ! obsolete positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
- GO:0035071 ! obsolete salivary gland cell autophagic cell death
p
