HUMAN:CASP2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CASP2 (synonyms: ICH1, NEDD2)
Protein Name(s)	Caspase-2 CASP-2 Neural precursor cell expressed developmentally down-regulated protein 2 NEDD-2 Protease ICH-1 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12
External Links
UniProt	P42575
EMBL	U13021 U13022 AF314174 AF314175 CR541748 AK291274 AY219042 AC073342 AC073342 AC073342 AC073342 CH471198 CH471198 CH471198 BC002427 BT007240 AB209640
CCDS	CCDS5879.1
PIR	A54821
RefSeq	NP_001215.1 NP_116764.2 NP_116765.2
UniGene	Hs.368982
PDB	1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM
PDBsum	1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM
ProteinModelPortal	P42575
SMR	P42575
BioGrid	107285
IntAct	P42575
MINT	MINT-150255
STRING	9606.ENSP00000312664
BindingDB	P42575
ChEMBL	CHEMBL4884
GuidetoPHARMACOLOGY	1618
MEROPS	C14.006
PhosphoSite	P42575
DMDM	83300977
MaxQB	P42575
PaxDb	P42575
PeptideAtlas	P42575
PRIDE	P42575
DNASU	835
Ensembl	ENST00000310447
GeneID	835
KEGG	hsa:835
UCSC	uc003wco.3 uc003wcp.3
CTD	835
GeneCards	GC07P142985
HGNC	HGNC:1503
HPA	CAB012175
MIM	600639
neXtProt	NX_P42575
PharmGKB	PA26086
eggNOG	NOG305976
GeneTree	ENSGT00760000118912
HOVERGEN	HBG103962
InParanoid	P42575
KO	K02186
OMA	PCLQVKP
OrthoDB	EOG7TTQ7K
PhylomeDB	P42575
TreeFam	TF102023
BRENDA	3.4.22.55
Reactome	REACT_13526 REACT_75776
ChiTaRS	CASP2
EvolutionaryTrace	P42575
GeneWiki	Caspase_2
GenomeRNAi	835
NextBio	3472
PMAP-CutDB	P42575
PRO	PR:P42575
Proteomes	UP000005640
Bgee	P42575
CleanEx	HS_CASP2
ExpressionAtlas	P42575
Genevestigator	P42575
GO	GO:0005737 GO:0005829 GO:0016020 GO:0005739 GO:0005634 GO:0004197 GO:0097153 GO:0019899 GO:0019904 GO:0007568 GO:0006915 GO:0097190 GO:0007420 GO:0071260 GO:0006977 GO:0035234 GO:0097194 GO:0097192 GO:0008630 GO:0001554 GO:0003407 GO:0048011 GO:0043065 GO:2001235 GO:0043525 GO:0016485 GO:0043281
Gene3D	1.10.533.10 3.40.50.1460
InterPro	IPR001315 IPR029030 IPR017350 IPR011029 IPR011600 IPR001309 IPR016129 IPR002138 IPR015917
Pfam	PF00619 PF00656
PIRSF	PIRSF038001
PRINTS	PR00376
SMART	SM00114 SM00115
SUPFAM	SSF47986
PROSITE	PS50209 PS01122 PS01121 PS50207 PS50208

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0019904	protein domain specific binding	PMID:9044836^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P78560	F		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	PMID:9044836^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:9044836^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:11156409^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:11156409^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:10980123^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11076957^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9C000	F		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	PMID:21726810^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(UniProtKB:P78560)\|has_input(UniProtKB:Q00987)	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:11156409^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:21726810^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q00987)	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:10980123^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97295 PANTHER:PTN000048135	P		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:97295 PANTHER:PTN000047947 UniProtKB:P42574 UniProtKB:Q14790	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010501 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033659 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:1277950 MGI:MGI:1312922 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:69274 UniProtKB:O15519 UniProtKB:P42574 UniProtKB:P55210 UniProtKB:P55211 UniProtKB:Q14790 WB:WBGene00000417	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033051 MGI:MGI:107739 MGI:MGI:1261423 MGI:MGI:1336166 MGI:MGI:97295 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:70967 UniProtKB:O15519 UniProtKB:P31944 UniProtKB:Q95ND5 UniProtKB:Q9ULZ3 WB:WBGene00000417	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26871637^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42575	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42575	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22531785^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42575	F		Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29594 ensembl:ENSMUSP00000031895	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29594 ensembl:ENSMUSP00000031895	P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29594 ensembl:ENSMUSP00000031895	P		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29594 ensembl:ENSMUSP00000031895	F		Seeded From UniProt	complete
involved_in	GO:0035234	ectopic germ cell programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29594 ensembl:ENSMUSP00000031895	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29594 ensembl:ENSMUSP00000031895	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29594 ensembl:ENSMUSP00000031895	C		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55215 ensembl:ENSRNOP00000022672	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55215 ensembl:ENSRNOP00000022672	C		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55215 ensembl:ENSRNOP00000022672	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55215 ensembl:ENSRNOP00000022672	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55215 ensembl:ENSRNOP00000022672	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55215 ensembl:ENSRNOP00000022672	C		Seeded From UniProt	complete
involved_in	GO:0003407	neural retina development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55215 ensembl:ENSRNOP00000022672	P		Seeded From UniProt	complete
involved_in	GO:0001554	luteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55215 ensembl:ENSRNOP00000022672	P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015917	F		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001315	P		Seeded From UniProt	complete
enables	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR035702	F		Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	PMID:18309324^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:18309324^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:18309324^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18309324^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	Reactome:R-HSA-5633008	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6800798 Reactome:R-HSA-6800797 Reactome:R-HSA-205117	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Ahmad, M et al. (1997) CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 57 615-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Droin, N et al. (2000) Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. 60 7039-47 PubMed GONUTS page
↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
↑ ^4.0 ^4.1 Torban, E et al. (2000) PAX2 suppresses apoptosis in renal collecting duct cells. Am. J. Pathol. 157 833-42 PubMed GONUTS page
↑ Hlaing, T et al. (2001) Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J. Biol. Chem. 276 9230-8 PubMed GONUTS page
↑ ^6.0 ^6.1 Oliver, TG et al. (2011) Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol. Cell 43 57-71 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yang, X et al. (2016) Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell 164 805-17 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
↑ Imre, G et al. (2012) Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J. 31 2615-28 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

[PMID:9044836-1] 1.0 ^1.1 ^1.2 Ahmad, M et al. (1997) CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 57 615-9 PubMed GONUTS page

[PMID:11156409-2] 2.0 ^2.1 ^2.2 Droin, N et al. (2000) Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. 60 7039-47 PubMed GONUTS page

[PMID:19593445-3] Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page

[PMID:10980123-4] 4.0 ^4.1 Torban, E et al. (2000) PAX2 suppresses apoptosis in renal collecting duct cells. Am. J. Pathol. 157 833-42 PubMed GONUTS page

[PMID:11076957-5] Hlaing, T et al. (2001) Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J. Biol. Chem. 276 9230-8 PubMed GONUTS page

[PMID:21726810-6] 6.0 ^6.1 Oliver, TG et al. (2011) Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol. Cell 43 57-71 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26871637-8] Yang, X et al. (2016) Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell 164 805-17 PubMed GONUTS page

[PMID:25416956-9] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:22531785-10] Imre, G et al. (2012) Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J. 31 2615-28 PubMed GONUTS page

[PMID:18309324-11] 11.0 ^11.1 ^11.2 ^11.3 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

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HUMAN:CASP2

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Annotations

Notes

References

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