DROME:ICENC

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Nc (ECO:0000312 with EMBL:AAF50180.1)
Protein Name(s)	Caspase Nc NEDD2-like caspase DRONC Caspase Nc subunit 1 Caspase Nc subunit 2
External Links
UniProt	Q9XYF4
EMBL	AF104357 AJ242796 AE014296 AY058747
RefSeq	NP_524017.1
UniGene	Dm.3230
PDB	1Q4Q 2FP3
PDBsum	1Q4Q 2FP3
ProteinModelPortal	Q9XYF4
SMR	Q9XYF4
BioGrid	64560
DIP	DIP-31484N
IntAct	Q9XYF4
MINT	MINT-8048660
STRING	7227.FBpp0076076
MEROPS	C14.019
PaxDb	Q9XYF4
PRIDE	Q9XYF4
EnsemblMetazoa	FBtr0076347
GeneID	39173
KEGG	dme:Dmel_CG8091
CTD	39173
FlyBase	FBgn0026404
eggNOG	NOG305976
GeneTree	ENSGT00760000118912
InParanoid	Q9XYF4
KO	K04489
OMA	LYFNPGF
OrthoDB	EOG7ZSHV0
PhylomeDB	Q9XYF4
EvolutionaryTrace	Q9XYF4
GenomeRNAi	39173
NextBio	812334
PRO	PR:Q9XYF4
Proteomes	UP000000803
Bgee	Q9XYF4
GO	GO:0043293 GO:0005737 GO:0050700 GO:0004197 GO:0004175 GO:0042803 GO:0006919 GO:0006915 GO:0048102 GO:0007417 GO:0048749 GO:0048813 GO:0008340 GO:0010623 GO:0035234 GO:0001700 GO:0008258 GO:0007516 GO:0035006 GO:0007552 GO:0008285 GO:0016322 GO:0045476 GO:0046672 GO:0012501 GO:0016540 GO:0051291 GO:0010506 GO:0010941 GO:0046668 GO:0035071 GO:0035070 GO:0007423 GO:0007291 GO:0031638
Gene3D	1.10.533.10 3.40.50.1460
InterPro	IPR029030 IPR017350 IPR011029 IPR011600 IPR001309 IPR016129 IPR002138 IPR015917
Pfam	PF00656
PIRSF	PIRSF038001
PRINTS	PR00376
SMART	SM00115
SUPFAM	SSF47986
PROSITE	PS01122 PS50207 PS50208

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0043065	positive regulation of apoptotic process	PMID:10200258^[1]	ECO:0000314			P	In figure 3 apoptosis occurs in cells with DRONC	complete
enables	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026404 PANTHER:PTN000047948 UniProtKB:Q14790 UniProtKB:Q92851	F	Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000825206 UniProtKB:Q14790	P	Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:97295 PANTHER:PTN000047947 UniProtKB:P42574 UniProtKB:Q14790	F	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026404 MGI:MGI:1261423 PANTHER:PTN000047948	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010501 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033659 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:1277950 MGI:MGI:1312922 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:69274 UniProtKB:O15519 UniProtKB:P42574 UniProtKB:P55210 UniProtKB:P55211 UniProtKB:Q14790 WB:WBGene00000417	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033051 MGI:MGI:107739 MGI:MGI:1261423 MGI:MGI:1336166 MGI:MGI:97295 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:70967 UniProtKB:O15519 UniProtKB:P31944 UniProtKB:Q95ND5 UniProtKB:Q9ULZ3 WB:WBGene00000417	C	Seeded From UniProt	complete
involved_in	GO:0035006	melanization defense response	PMID:24746817^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:24036278^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0260945	P	Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	PMID:23722427^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0259822	P	Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	PMID:23722427^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035234	ectopic germ cell programmed cell death	PMID:23523076^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:22555454^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	PMID:21220123^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	PMID:21220123^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050700	CARD domain binding	PMID:21220123^[8]	ECO:0000255	match to sequence model evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
part_of	GO:0043293	apoptosome	PMID:21220123^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	PMID:21120926^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010941	regulation of cell death	PMID:20700104^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	PMID:20445064^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:17310982^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045476	nurse cell apoptotic process	PMID:17464325^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0033051	P	Seeded From UniProt	complete
involved_in	GO:0010623	programmed cell death involved in cell development	PMID:16980627^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035070	salivary gland histolysis	PMID:16485033^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046672	positive regulation of compound eye retinal cell programmed cell death	PMID:16485033^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	PMID:16980964^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016540	protein autoprocessing	PMID:16446367^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031638	zymogen activation	PMID:16446367^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:16446367^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0031638	zymogen activation	PMID:16446367^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:16446367^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:16222340^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0022416	chaeta development	PMID:16222340^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007291	sperm individualization	PMID:16362035^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:16303568^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:15800001^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007516	hemocyte development	PMID:15572131^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:15572131^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008258	head involution	PMID:15572131^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048749	compound eye development	PMID:15572131^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:15572131^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	PMID:15107838^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	PMID:15107838^[23]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:12938178^[24]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007291	sperm individualization	PMID:14737191^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046668	regulation of retinal cell programmed cell death	PMID:12547518^[26]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001700	embryonic development via the syncytial blastoderm	PMID:11139276^[27]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10675329^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10675329^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0260635	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10675329^[28]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0260635	P	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:10675329^[28]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
NOT\|part_of	GO:0005739	mitochondrion	PMID:10200258^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:10200258^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	WB:WBGene00000417	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10200258^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:10200258^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10200258^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10200258^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010940	positive regulation of necrotic cell death	PMID:28945745^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097199	P	Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097199	P	Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097199	P	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398	P	Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015917	F	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:12547518^[26] PMID:12072176^[30] PMID:11139276^[27] PMID:11178240^[31] PMID:10511707^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001700	embryonic development via the syncytial blastoderm	PMID:12072176^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:12072176^[30] PMID:11139276^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007552	metamorphosis	PMID:11139276^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Dorstyn, L et al. (1999) DRONC, an ecdysone-inducible Drosophila caspase. Proc. Natl. Acad. Sci. U.S.A. 96 4307-12 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Obata, F et al. (2014) Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis. Cell Rep 7 821-33 PubMed GONUTS page
↑ Liu, H et al. (2013) Balancing crosstalk between 20-hydroxyecdysone-induced autophagy and caspase activity in the fat body during Drosophila larval-prepupal transition. Insect Biochem. Mol. Biol. 43 1068-78 PubMed GONUTS page
↑ ^5.0 ^5.1 Kanamori, T et al. (2013) Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons. Science 340 1475-8 PubMed GONUTS page
↑ Yacobi-Sharon, K et al. (2013) Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart. Dev. Cell 25 29-42 PubMed GONUTS page
↑ Verghese, S et al. (2012) Hippo signalling controls Dronc activity to regulate organ size in Drosophila. Cell Death Differ. 19 1664-76 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Yuan, S et al. (2011) Structure of the Drosophila apoptosome at 6.9 å resolution. Structure 19 128-40 PubMed GONUTS page
↑ Lee, G et al. (2011) Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. J. Comp. Neurol. 519 34-48 PubMed GONUTS page
↑ Yang, CS et al. (2010) Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. EMBO J. 29 3196-207 PubMed GONUTS page
↑ Schoenmann, Z et al. (2010) Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. J. Neurosci. 30 6375-86 PubMed GONUTS page
↑ Akdemir, F et al. (2007) p53 directs focused genomic responses in Drosophila. Oncogene 26 5184-93 PubMed GONUTS page
↑ Baum, JS et al. (2007) The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ. 14 1508-17 PubMed GONUTS page
↑ Kondo, S et al. (2006) DRONC coordinates cell death and compensatory proliferation. Mol. Cell. Biol. 26 7258-68 PubMed GONUTS page
↑ ^15.0 ^15.1 Leulier, F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 13 1663-74 PubMed GONUTS page
↑ Williams, DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat. Neurosci. 9 1234-6 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Yan, N et al. (2006) Structure and activation mechanism of the Drosophila initiator caspase Dronc. J. Biol. Chem. 281 8667-74 PubMed GONUTS page
↑ ^18.0 ^18.1 Kanuka, H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 24 3793-806 PubMed GONUTS page
↑ Arama, E et al. (2006) The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J. 25 232-43 PubMed GONUTS page
↑ Bauer, JH et al. (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15 2063-8 PubMed GONUTS page
↑ Xu, D et al. (2005) The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 132 2125-34 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Chew, SK et al. (2004) The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev. Cell 7 897-907 PubMed GONUTS page
↑ ^23.0 ^23.1 Yan, N et al. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat. Struct. Mol. Biol. 11 420-8 PubMed GONUTS page
↑ Lawen, A (2003) Apoptosis-an introduction. Bioessays 25 888-96 PubMed GONUTS page
↑ Huh, JR et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2 E15 PubMed GONUTS page
↑ ^26.0 ^26.1 Brachmann, CB & Cagan, RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet. 19 91-6 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Kumar, S & Doumanis, J (2000) The fly caspases. Cell Death Differ. 7 1039-44 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Meier, P et al. (2000) The Drosophila caspase DRONC is regulated by DIAP1. EMBO J. 19 598-611 PubMed GONUTS page
↑ Napoletano, F et al. (2017) p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis. PLoS Genet. 13 e1007024 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
↑ Tittel, JN & Steller, H (2000) A comparison of programmed cell death between species. Genome Biol. 1 REVIEWS0003 PubMed GONUTS page
↑ Abrams, JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol. 9 435-40 PubMed GONUTS page

[PMID:10200258-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Dorstyn, L et al. (1999) DRONC, an ecdysone-inducible Drosophila caspase. Proc. Natl. Acad. Sci. U.S.A. 96 4307-12 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24746817-3] Obata, F et al. (2014) Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis. Cell Rep 7 821-33 PubMed GONUTS page

[PMID:24036278-4] Liu, H et al. (2013) Balancing crosstalk between 20-hydroxyecdysone-induced autophagy and caspase activity in the fat body during Drosophila larval-prepupal transition. Insect Biochem. Mol. Biol. 43 1068-78 PubMed GONUTS page

[PMID:23722427-5] 5.0 ^5.1 Kanamori, T et al. (2013) Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons. Science 340 1475-8 PubMed GONUTS page

[PMID:23523076-6] Yacobi-Sharon, K et al. (2013) Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart. Dev. Cell 25 29-42 PubMed GONUTS page

[PMID:22555454-7] Verghese, S et al. (2012) Hippo signalling controls Dronc activity to regulate organ size in Drosophila. Cell Death Differ. 19 1664-76 PubMed GONUTS page

[PMID:21220123-8] 8.0 ^8.1 ^8.2 ^8.3 Yuan, S et al. (2011) Structure of the Drosophila apoptosome at 6.9 å resolution. Structure 19 128-40 PubMed GONUTS page

[PMID:21120926-9] Lee, G et al. (2011) Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. J. Comp. Neurol. 519 34-48 PubMed GONUTS page

[PMID:20700104-10] Yang, CS et al. (2010) Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. EMBO J. 29 3196-207 PubMed GONUTS page

[PMID:20445064-11] Schoenmann, Z et al. (2010) Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. J. Neurosci. 30 6375-86 PubMed GONUTS page

[PMID:17310982-12] Akdemir, F et al. (2007) p53 directs focused genomic responses in Drosophila. Oncogene 26 5184-93 PubMed GONUTS page

[PMID:17464325-13] Baum, JS et al. (2007) The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ. 14 1508-17 PubMed GONUTS page

[PMID:16980627-14] Kondo, S et al. (2006) DRONC coordinates cell death and compensatory proliferation. Mol. Cell. Biol. 26 7258-68 PubMed GONUTS page

[PMID:16485033-15] 15.0 ^15.1 Leulier, F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 13 1663-74 PubMed GONUTS page

[PMID:16980964-16] Williams, DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat. Neurosci. 9 1234-6 PubMed GONUTS page

[PMID:16446367-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Yan, N et al. (2006) Structure and activation mechanism of the Drosophila initiator caspase Dronc. J. Biol. Chem. 281 8667-74 PubMed GONUTS page

[PMID:16222340-18] 18.0 ^18.1 Kanuka, H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 24 3793-806 PubMed GONUTS page

[PMID:16362035-19] Arama, E et al. (2006) The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J. 25 232-43 PubMed GONUTS page

[PMID:16303568-20] Bauer, JH et al. (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15 2063-8 PubMed GONUTS page

[PMID:15800001-21] Xu, D et al. (2005) The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 132 2125-34 PubMed GONUTS page

[PMID:15572131-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Chew, SK et al. (2004) The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev. Cell 7 897-907 PubMed GONUTS page

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[PMID:14737191-25] Huh, JR et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2 E15 PubMed GONUTS page

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