It is now the 5th OPEN Period for CACAO Fall 2017! It will end on Tuesday November 21, 2017 at 11:59 pm CST
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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DROME:ICENC

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Nc (ECO:0000312 with EMBL:AAF50180.1)
Protein Name(s) Caspase Nc

NEDD2-like caspase DRONC Caspase Nc subunit 1 Caspase Nc subunit 2

External Links
UniProt Q9XYF4
EMBL AF104357
AJ242796
AE014296
AY058747
RefSeq NP_524017.1
UniGene Dm.3230
PDB 1Q4Q
2FP3
PDBsum 1Q4Q
2FP3
ProteinModelPortal Q9XYF4
SMR Q9XYF4
BioGrid 64560
DIP DIP-31484N
IntAct Q9XYF4
MINT MINT-8048660
STRING 7227.FBpp0076076
MEROPS C14.019
PaxDb Q9XYF4
PRIDE Q9XYF4
EnsemblMetazoa FBtr0076347
GeneID 39173
KEGG dme:Dmel_CG8091
CTD 39173
FlyBase FBgn0026404
eggNOG NOG305976
GeneTree ENSGT00760000118912
InParanoid Q9XYF4
KO K04489
OMA LYFNPGF
OrthoDB EOG7ZSHV0
PhylomeDB Q9XYF4
EvolutionaryTrace Q9XYF4
GenomeRNAi 39173
NextBio 812334
PRO PR:Q9XYF4
Proteomes UP000000803
Bgee Q9XYF4
GO GO:0043293
GO:0005737
GO:0050700
GO:0004197
GO:0004175
GO:0042803
GO:0006919
GO:0006915
GO:0048102
GO:0007417
GO:0048749
GO:0048813
GO:0008340
GO:0010623
GO:0035234
GO:0001700
GO:0008258
GO:0007516
GO:0035006
GO:0007552
GO:0008285
GO:0016322
GO:0045476
GO:0046672
GO:0012501
GO:0016540
GO:0051291
GO:0010506
GO:0010941
GO:0046668
GO:0035071
GO:0035070
GO:0007423
GO:0007291
GO:0031638
Gene3D 1.10.533.10
3.40.50.1460
InterPro IPR029030
IPR017350
IPR011029
IPR011600
IPR001309
IPR016129
IPR002138
IPR015917
Pfam PF00656
PIRSF PIRSF038001
PRINTS PR00376
SMART SM00115
SUPFAM SSF47986
PROSITE PS01122
PS50207
PS50208

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0043065

positive regulation of apoptotic process

PMID:10200258[1]

IDA: Inferred from Direct Assay

P

In figure 3 apoptosis occurs in cells with DRONC

complete

GO:0001700

embryonic development via the syncytial blastoderm

PMID:11139276[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0001700

embryonic development via the syncytial blastoderm

PMID:12072176[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0004175

endopeptidase activity

PMID:16446367[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004197

cysteine-type endopeptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001309
InterPro:IPR002138
InterPro:IPR011600
InterPro:IPR016129

F

Seeded From UniProt

complete

GO:0004197

cysteine-type endopeptidase activity

PMID:10200258[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004197

cysteine-type endopeptidase activity

PMID:10511707[5]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004197

cysteine-type endopeptidase activity

PMID:10675329[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004197

cysteine-type endopeptidase activity

PMID:11139276[2]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004197

cysteine-type endopeptidase activity

PMID:11178240[7]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004197

cysteine-type endopeptidase activity

PMID:12072176[3]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004197

cysteine-type endopeptidase activity

PMID:12547518[8]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004197

cysteine-type endopeptidase activity

PMID:16222340[9]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10675329[6]

IPI: Inferred from Physical Interaction

UniProtKB:O01382

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10675329[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021771[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14517550[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20700104[12]

IPI: Inferred from Physical Interaction

UniProtKB:O01382

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20700104[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q24306

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:10200258[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001309
InterPro:IPR002138
InterPro:IPR011600
InterPro:IPR016129

P

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015917

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10200258[1]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10200258[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10675329[6]

IGI: Inferred from Genetic Interaction

FB:FBgn0260635

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10675329[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10675329[6]

IPI: Inferred from Physical Interaction

FB:FBgn0260635

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:11139276[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:12072176[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:12938178[13]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:15572131[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:15800001[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:17310982[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007291

sperm individualization

PMID:14737191[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007291

sperm individualization

PMID:16362035[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007417

central nervous system development

PMID:15572131[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007423

sensory organ development

PMID:16222340[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007516

hemocyte development

PMID:15572131[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007552

metamorphosis

PMID:11139276[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008233

peptidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

GO:0008234

cysteine-type peptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015917

F

Seeded From UniProt

complete

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

GO:0008258

head involution

PMID:15572131[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008285

negative regulation of cell proliferation

PMID:22555454[19]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:16303568[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010506

regulation of autophagy

PMID:24036278[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0260945

P

Seeded From UniProt

complete

GO:0010623

developmental programmed cell death

PMID:16980627[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010941

regulation of cell death

PMID:20700104[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:21120926[23]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016322

neuron remodeling

PMID:20445064[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016540

protein autoprocessing

PMID:16446367[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0031638

zymogen activation

PMID:16446367[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031638

zymogen activation

PMID:16446367[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035006

melanization defense response

PMID:24746817[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035070

salivary gland histolysis

PMID:16485033[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035071

salivary gland cell autophagic cell death

PMID:12593804[27]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0035234

ectopic germ cell programmed cell death

PMID:23523076[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042803

protein homodimerization activity

PMID:16446367[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0043293

apoptosome

PMID:21220123[29]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045476

nurse cell apoptotic process

PMID:17464325[30]

IGI: Inferred from Genetic Interaction

FB:FBgn0033051

P

Seeded From UniProt

complete

GO:0046668

regulation of retinal cell programmed cell death

PMID:12547518[8]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046672

positive regulation of compound eye retinal cell programmed cell death

PMID:16485033[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048102

autophagic cell death

PMID:12593804[27]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0048749

compound eye development

PMID:15572131[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048813

dendrite morphogenesis

PMID:16980964[31]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050700

CARD domain binding

PMID:21220123[29]

ISM: Inferred from Sequence Model

F

Seeded From UniProt

Missing: with/from

GO:0051291

protein heterooligomerization

PMID:21220123[29]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:15107838[32]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

PMID:21220123[29]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0097194

execution phase of apoptosis

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000825206

P

Seeded From UniProt

complete

GO:0097199

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

PMID:15107838[32]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0097200

cysteine-type endopeptidase activity involved in execution phase of apoptosis

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000825206

F

Seeded From UniProt

complete

GO:2001269

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

PMID:15107838[32]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

NOT

GO:0005739

mitochondrion

PMID:10200258[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

contributes_to

GO:0097199

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

PMID:21220123[29]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Dorstyn, L et al. (1999) DRONC, an ecdysone-inducible Drosophila caspase. Proc. Natl. Acad. Sci. U.S.A. 96 4307-12 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Kumar, S & Doumanis, J (2000) The fly caspases. Cell Death Differ. 7 1039-44 PubMed GONUTS page
  3. 3.0 3.1 3.2 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Yan, N et al. (2006) Structure and activation mechanism of the Drosophila initiator caspase Dronc. J. Biol. Chem. 281 8667-74 PubMed GONUTS page
  5. Abrams, JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol. 9 435-40 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Meier, P et al. (2000) The Drosophila caspase DRONC is regulated by DIAP1. EMBO J. 19 598-611 PubMed GONUTS page
  7. Tittel, JN & Steller, H (2000) A comparison of programmed cell death between species. Genome Biol. 1 REVIEWS0003 PubMed GONUTS page
  8. 8.0 8.1 Brachmann, CB & Cagan, RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet. 19 91-6 PubMed GONUTS page
  9. 9.0 9.1 Kanuka, H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 24 3793-806 PubMed GONUTS page
  10. Wilson, R et al. (2002) The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat. Cell Biol. 4 445-50 PubMed GONUTS page
  11. Chai, J et al. (2003) Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat. Struct. Biol. 10 892-8 PubMed GONUTS page
  12. 12.0 12.1 12.2 Yang, CS et al. (2010) Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. EMBO J. 29 3196-207 PubMed GONUTS page
  13. Lawen, A (2003) Apoptosis-an introduction. Bioessays 25 888-96 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 Chew, SK et al. (2004) The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev. Cell 7 897-907 PubMed GONUTS page
  15. Xu, D et al. (2005) The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 132 2125-34 PubMed GONUTS page
  16. Akdemir, F et al. (2007) p53 directs focused genomic responses in Drosophila. Oncogene 26 5184-93 PubMed GONUTS page
  17. Huh, JR et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2 E15 PubMed GONUTS page
  18. Arama, E et al. (2006) The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J. 25 232-43 PubMed GONUTS page
  19. Verghese, S et al. (2012) Hippo signalling controls Dronc activity to regulate organ size in Drosophila. Cell Death Differ. 19 1664-76 PubMed GONUTS page
  20. Bauer, JH et al. (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15 2063-8 PubMed GONUTS page
  21. Liu, H et al. (2013) Balancing crosstalk between 20-hydroxyecdysone-induced autophagy and caspase activity in the fat body during Drosophila larval-prepupal transition. Insect Biochem. Mol. Biol. 43 1068-78 PubMed GONUTS page
  22. Kondo, S et al. (2006) DRONC coordinates cell death and compensatory proliferation. Mol. Cell. Biol. 26 7258-68 PubMed GONUTS page
  23. Lee, G et al. (2011) Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. J. Comp. Neurol. 519 34-48 PubMed GONUTS page
  24. Schoenmann, Z et al. (2010) Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. J. Neurosci. 30 6375-86 PubMed GONUTS page
  25. Obata, F et al. (2014) Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis. Cell Rep 7 821-33 PubMed GONUTS page
  26. 26.0 26.1 Leulier, F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 13 1663-74 PubMed GONUTS page
  27. 27.0 27.1 Gorski, SM et al. (2003) A SAGE approach to discovery of genes involved in autophagic cell death. Curr. Biol. 13 358-63 PubMed GONUTS page
  28. Yacobi-Sharon, K et al. (2013) Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart. Dev. Cell 25 29-42 PubMed GONUTS page
  29. 29.0 29.1 29.2 29.3 29.4 Yuan, S et al. (2011) Structure of the Drosophila apoptosome at 6.9 å resolution. Structure 19 128-40 PubMed GONUTS page
  30. Baum, JS et al. (2007) The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ. 14 1508-17 PubMed GONUTS page
  31. Williams, DW et al. (2006) Local caspase activity directs engulfment of dendrites during pruning. Nat. Neurosci. 9 1234-6 PubMed GONUTS page
  32. 32.0 32.1 32.2 Yan, N et al. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat. Struct. Mol. Biol. 11 420-8 PubMed GONUTS page