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PMID:24036278

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Citation

Liu, H, Jia, Q, Tettamanti, G and Li, S (2013) Balancing crosstalk between 20-hydroxyecdysone-induced autophagy and caspase activity in the fat body during Drosophila larval-prepupal transition. Insect Biochem. Mol. Biol. 43:1068-78

Abstract

In the fruitfly, Drosophila melanogaster, autophagy and caspase activity function in parallel in the salivary gland during metamorphosis and in a common regulatory hierarchy during oogenesis. Both autophagy and caspase activity progressively increase in the remodeling fat body, and they are induced by a pulse of the molting hormone (20-hydroxyecdysone, 20E) during the larval-prepupal transition. Inhibition of autophagy and/or caspase activity in the remodeling fat body results in 25-40% pupal lethality, depending on the genotypes. Interestingly, a balancing crosstalk occurs between autophagy and caspase activity in this tissue: the inhibition of autophagy induces caspase activity and the inhibition of caspases induces autophagy. The Drosophila remodeling fat body provides an in vivo model for understanding the molecular mechanism of the balancing crosstalk between autophagy and caspase activity, which oppose with each other and are induced by the common stimulus 20E, and blockage of either path reinforces the other path.

Links

PubMed Online version:10.1016/j.ibmb.2013.09.001

Keywords

Animals; Autophagy; Caspases/genetics; Caspases/metabolism; Drosophila/enzymology; Drosophila/genetics; Drosophila/growth & development; Drosophila/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Ecdysterone/metabolism; Fat Body/enzymology; Fat Body/metabolism; Gene Expression Regulation, Developmental; Larva/enzymology; Larva/genetics; Larva/growth & development; Larva/physiology; Pupa/enzymology; Pupa/genetics; Pupa/growth & development; Pupa/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:ECR

involved_in

GO:0010506: regulation of autophagy

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8MQJ7

involved_in

GO:0010506: regulation of autophagy

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0026404

P

Seeded From UniProt

complete

DROME:Q9VU14

involved_in

GO:0010506: regulation of autophagy

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0026404

P

Seeded From UniProt

complete

DROME:Q9W2S2

involved_in

GO:0006914: autophagy

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DRONC

involved_in

GO:0010506: regulation of autophagy

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0260945

P

Seeded From UniProt

complete

DROME:X2JEE0

involved_in

GO:0006914: autophagy

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:X2JJA8

involved_in

GO:0006914: autophagy

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:ICENC

involved_in

GO:0010506: regulation of autophagy

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0260945

P

Seeded From UniProt

complete

Notes

See also

References

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