MOUSE:CD28

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cd28
Protein Name(s)	T-cell-specific surface glycoprotein CD28
External Links
UniProt	P31041
EMBL	M34563 AL646054 AL672024 CR936842 CH466548 BC064058 M74361
CCDS	CCDS14992.1
PIR	A43523 I49584
RefSeq	NP_031668.3
UniGene	Mm.255003
ProteinModelPortal	P31041
SMR	P31041
DIP	DIP-60858N
IntAct	P31041
STRING	10090.ENSMUSP00000027165
PhosphoSite	P31041
PRIDE	P31041
Ensembl	ENSMUST00000027165
GeneID	12487
KEGG	mmu:12487
UCSC	uc007bev.2 uc007bew.2
CTD	940
MGI	MGI:88327
eggNOG	NOG48152
GeneTree	ENSGT00530000063873
HOGENOM	HOG000276892
HOVERGEN	HBG004094
InParanoid	P31041
KO	K06470
OMA	NHTDIYF
OrthoDB	EOG7W6WMJ
TreeFam	TF335679
Reactome	REACT_196588 REACT_204081 REACT_226151 REACT_226341 REACT_261451
NextBio	281396
PRO	PR:P31041
Proteomes	UP000000589
CleanEx	MM_CD28
Genevestigator	P31041
GO	GO:0009897 GO:0001772 GO:0016021 GO:0097190 GO:0006955 GO:0045060 GO:0046641 GO:0002863 GO:0045086 GO:0048304 GO:0045840 GO:0014068 GO:0051897 GO:0042102 GO:0045944 GO:0045066 GO:0031295 GO:0050852
Gene3D	2.60.40.10
InterPro	IPR008093 IPR013783 IPR003599 IPR013106
Pfam	PF07686
PRINTS	PR01717
SMART	SM00409

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0045086	positive regulation of interleukin-2 biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN002608477	P		Seeded From UniProt	complete
involved_in	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN000161013 UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN000161013 RGD:2299 UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN000161013 UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN000161013 RGD:2299	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 MGI:MGI:88556 PANTHER:PTN002608477 UniProtKB:P10747 UniProtKB:P16410	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN002608477 RGD:2299 UniProtKB:P10747 UniProtKB:P16410	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2299	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21245484^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06240	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:23589618^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:7688139^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:8125140^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000624)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:7790813^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:23793062^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:12874832^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	C		Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002863	positive regulation of inflammatory response to antigenic stimulus	PMID:10791997^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P	regulates_o_has_participant:(EMAPA:17577)	Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	F		Seeded From UniProt	complete
part_of	GO:0001772	immunological synapse	PMID:23793062^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098636	protein complex involved in cell adhesion	PMID:7544393^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:10429671^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	PMID:23589618^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050852	T cell receptor signaling pathway	PMID:23793062^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048304	positive regulation of isotype switching to IgG isotypes	PMID:7688139^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046641	positive regulation of alpha-beta T cell proliferation	PMID:9368605^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046641	positive regulation of alpha-beta T cell proliferation	PMID:9368605^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046641	positive regulation of alpha-beta T cell proliferation	PMID:8125140^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046641	positive regulation of alpha-beta T cell proliferation	PMID:14973438^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16809611^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1929913	P	regulates_o_occurs_in:(CL:0000084) has_regulation_target:(MGI:MGI:96548)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045589	regulation of regulatory T cell differentiation	PMID:21245484^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96756 MGI:MGI:98725	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2299	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:7688139^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045086	positive regulation of interleukin-2 biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045066	regulatory T cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045060	negative thymic T cell selection	PMID:10429671^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P	has_participant:(EMAPA:18768)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2299	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042110	T cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042110	T cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2299	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:7688139^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:10791997^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:15240667^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:12925852^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:12867038^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10747	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	PMID:23793062^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	PMID:9368605^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	PMID:7688139^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	PMID:9368605^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	PMID:8125140^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	PMID:15240667^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	PMID:12925852^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	PMID:10429671^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098636	protein complex involved in cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	C		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	P		Seeded From UniProt	complete
involved_in	GO:0045086	positive regulation of interleukin-2 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	P		Seeded From UniProt	complete
involved_in	GO:0045066	regulatory T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	P		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	C		Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10747 ensembl:ENSP00000324890	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008093	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008093	C		Seeded From UniProt	complete
involved_in	GO:0042129	regulation of T cell proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040216	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 Semple, K et al. (2011) Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling. Blood 117 3096-103 PubMed GONUTS page
↑ ^3.0 ^3.1 Ammann, JU et al. (2013) Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J. Immunol. 190 5030-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Shahinian, A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261 609-12 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hubbe, M & Altevogt, P (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur. J. Immunol. 24 731-7 PubMed GONUTS page
↑ Sperling, AI et al. (1995) CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182 139-46 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page
↑ Butler, JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J. Cell. Biochem. 89 975-91 PubMed GONUTS page
↑ ^9.0 ^9.1 Bai, XF et al. (2000) The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis. J. Clin. Invest. 105 1227-32 PubMed GONUTS page
↑ Fargeas, CA et al. (1995) Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182 667-75 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Kishimoto, H & Sprent, J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190 65-73 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Zhou, Q et al. (1997) Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion. Eur. J. Immunol. 27 2524-8 PubMed GONUTS page
↑ Heissmeyer, V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5 255-65 PubMed GONUTS page
↑ Cismasiu, VB et al. (2006) BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Blood 108 2695-702 PubMed GONUTS page
↑ ^15.0 ^15.1 Ng, LG et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 173 807-17 PubMed GONUTS page
↑ ^16.0 ^16.1 Suh, WK et al. (2003) The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 4 899-906 PubMed GONUTS page
↑ Egawa, T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr. Biol. 13 1252-8 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21245484-2] 2.0 ^2.1 Semple, K et al. (2011) Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling. Blood 117 3096-103 PubMed GONUTS page

[PMID:23589618-3] 3.0 ^3.1 Ammann, JU et al. (2013) Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J. Immunol. 190 5030-6 PubMed GONUTS page

[PMID:7688139-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Shahinian, A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261 609-12 PubMed GONUTS page

[PMID:8125140-5] 5.0 ^5.1 ^5.2 Hubbe, M & Altevogt, P (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur. J. Immunol. 24 731-7 PubMed GONUTS page

[PMID:7790813-6] Sperling, AI et al. (1995) CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182 139-46 PubMed GONUTS page

[PMID:23793062-7] 7.0 ^7.1 ^7.2 ^7.3 Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page

[PMID:12874832-8] Butler, JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J. Cell. Biochem. 89 975-91 PubMed GONUTS page

[PMID:10791997-9] 9.0 ^9.1 Bai, XF et al. (2000) The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis. J. Clin. Invest. 105 1227-32 PubMed GONUTS page

[PMID:7544393-10] Fargeas, CA et al. (1995) Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182 667-75 PubMed GONUTS page

[PMID:10429671-11] 11.0 ^11.1 ^11.2 Kishimoto, H & Sprent, J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190 65-73 PubMed GONUTS page

[PMID:9368605-12] 12.0 ^12.1 ^12.2 ^12.3 Zhou, Q et al. (1997) Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion. Eur. J. Immunol. 27 2524-8 PubMed GONUTS page

[PMID:14973438-13] Heissmeyer, V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5 255-65 PubMed GONUTS page

[PMID:16809611-14] Cismasiu, VB et al. (2006) BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Blood 108 2695-702 PubMed GONUTS page

[PMID:15240667-15] 15.0 ^15.1 Ng, LG et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 173 807-17 PubMed GONUTS page

[PMID:12925852-16] 16.0 ^16.1 Suh, WK et al. (2003) The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 4 899-906 PubMed GONUTS page

[PMID:12867038-17] Egawa, T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr. Biol. 13 1252-8 PubMed GONUTS page

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MOUSE:CD28

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