GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:7790813
| Citation |
Sperling, AI, Green, JM, Mosley, RL, Smith, PL, DiPaolo, RJ, Klein, JR, Bluestone, JA and Thompson, CB (1995) CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182:139-46 |
|---|---|
| Abstract |
Costimulation mediated by the CD28 receptor has been shown to play an important role in the development of a vigorous T cell immune response. Nevertheless, CD28-deficient mice can mount effective T cell-dependent immune responses. These data suggest that other costimulatory molecules may play a role in T cell activation. In a search for other costimulatory receptors on T cells, we have characterized a monoclonal antibody (mAb) that can costimulate T cells in the absence of accessory cells. Similar to CD28 antibodies, this mAb, R2/60, was found to synergize with T cell receptor engagement in inducing proliferation. Independent ligation of CD3 and the ligand recognized by R2/60 results in T cell proliferation, suggesting that the two molecules do not have to colocalize to activate the R2/60 costimulatory pathway. R2/60 does not react with CD28, and furthermore, R2/60 costimulates in a CD28-independent fashion since the mAb costimulates T cells from the CD28-deficient mice as well as wild-type mice. Expression cloning of the R2/60 antigen identified the ligand as murine CD43. Together, these data demonstrate that CD43 can serve as a receptor on T cells that can provide CD28-independent costimulation. |
| Links | |
| Keywords |
Animals; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/pharmacology; Antigens, CD; Antigens, CD28/genetics; Antigens, CD28/physiology; Antigens, CD3/immunology; Antigens, CD43; Ligands; Lymph Nodes/cytology; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Sialoglycoproteins/immunology; Sialoglycoproteins/physiology; Signal Transduction; Specific Pathogen-Free Organisms; T-Lymphocyte Subsets/immunology; Thymus Gland/cytology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
