MOUSE:CAV1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cav1 (synonyms: Cav)
Protein Name(s)	Caveolin-1
External Links
UniProt	P49817
EMBL	U07645 AB029929 AB029930 AB029931 AY439333 AK003489 AK028738 AK035592 AK090074 BC038280 BC052859
CCDS	CCDS19924.1
PIR	I48976
RefSeq	NP_001229993.1 NP_031642.1 XP_006505037.1 XP_006505038.1 XP_006505039.1
UniGene	Mm.28278
BioGrid	198514
DIP	DIP-35140N
IntAct	P49817
MINT	MINT-1542313
PhosphoSite	P49817
MaxQB	P49817
PaxDb	P49817
PRIDE	P49817
Ensembl	ENSMUST00000007799 ENSMUST00000115453 ENSMUST00000115454 ENSMUST00000115456
GeneID	12389
KEGG	mmu:12389
UCSC	uc009azo.2
CTD	857
MGI	MGI:102709
eggNOG	NOG86001
GeneTree	ENSGT00390000014924
HOGENOM	HOG000036550
HOVERGEN	HBG003422
InParanoid	P49817
KO	K06278
OMA	VHTFCDP
OrthoDB	EOG7V1FSD
PhylomeDB	P49817
TreeFam	TF315736
Reactome	REACT_211508 REACT_215995 REACT_216784 REACT_221264 REACT_245618 REACT_261840
NextBio	281122
PRO	PR:P49817
Proteomes	UP000000589
Bgee	P49817
CleanEx	MM_CAV1
ExpressionAtlas	P49817
Genevestigator	P49817
GO	GO:0002080 GO:0016324 GO:0016323 GO:0005901 GO:0005938 GO:0005929 GO:0031410 GO:0005783 GO:0005768 GO:0005794 GO:0000139 GO:0016021 GO:0005887 GO:0016020 GO:0045121 GO:0048471 GO:0005886 GO:0043234 GO:0016504 GO:0005198 GO:0001525 GO:0097190 GO:0055074 GO:0006816 GO:0070836 GO:0072584 GO:0006874 GO:0071455 GO:0009267 GO:0071560 GO:0042632 GO:0051480 GO:0006897 GO:0000188 GO:0007595 GO:0019915 GO:0030879 GO:0060056 GO:0000165 GO:0051899 GO:2000811 GO:0030514 GO:0090090 GO:0008285 GO:0001960 GO:0001937 GO:0030857 GO:0046426 GO:0043407 GO:0043409 GO:0045019 GO:0051001 GO:0033137 GO:0048550 GO:0032091 GO:0031397 GO:0009968 GO:0000122 GO:0042524 GO:0033484 GO:0010524 GO:0090263 GO:2001238 GO:2001244 GO:0048554 GO:0010952 GO:0033138 GO:0045907 GO:0051260 GO:0008104 GO:0051259 GO:2000286 GO:0030193 GO:0019217 GO:0052547 GO:0006940 GO:0002026 GO:0003057 GO:0051592 GO:0043627 GO:0001666 GO:0002931 GO:0032570 GO:0007519 GO:0031295 GO:0006641 GO:0001570 GO:0042310 GO:0016050
InterPro	IPR001612 IPR015504 IPR018361
PANTHER	PTHR10844 PTHR10844:SF5
Pfam	PF01146
PROSITE	PS01210

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060546	negative regulation of necroptosis	PMID:23049990^[1]	ECO:0000315			P		Figure 5 shows that "fibrosis and cell death characterises adipose tissue from CAV1 -/- mice".	complete CACAO 6147
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:15734843^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
involved_in	GO:0060546	negative regulation of necroptotic process	PMID:23049990^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:25017399^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	PMID:25017399^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:25017399^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005925	focal adhesion	PMID:12091389^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:8552590^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9361015^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9WVC3	F		Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	PMID:25006397^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q03135	P	occurs_in:(CL:1001567)	Seeded From UniProt	complete
involved_in	GO:1903598	positive regulation of gap junction assembly	PMID:25017399^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0086098	angiotensin-activated signaling pathway involved in heart process	PMID:25017399^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09470	P		Seeded From UniProt	complete
involved_in	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	PMID:25017399^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:25017399^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098911	regulation of ventricular cardiac muscle cell action potential	PMID:25017399^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25017399^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P23242) occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0010608	posttranscriptional regulation of gene expression	PMID:25017399^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P23242) occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:1900085	negative regulation of peptidyl-tyrosine autophosphorylation	PMID:25017399^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P05480) occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0061099	negative regulation of protein tyrosine kinase activity	PMID:25017399^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P05480) occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	PMID:25017399^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09470	P	occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	PMID:25017399^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P70313	F	occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:25017399^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05480	F	occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:19052258^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010524	positive regulation of calcium ion transport into cytosol	PMID:19052258^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	PMID:22277751^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:10816572^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:22277751^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10816572^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107570 PANTHER:PTN000851526 UniProtKB:P51636 UniProtKB:P56539 UniProtKB:Q03135	P		Seeded From UniProt	complete
involved_in	GO:0061099	negative regulation of protein tyrosine kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 UniProtKB:Q03135	P		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107571 PANTHER:PTN000851526 RGD:2281 UniProtKB:P56539	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 RGD:2280 UniProtKB:Q03135	C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000090213 RGD:2280 UniProtKB:Q03135	F		Seeded From UniProt	complete
colocalizes_with	GO:0042383	sarcolemma	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107570 PANTHER:PTN000090155 RGD:2281 UniProtKB:P56539 UniProtKB:P79132 UniProtKB:Q2KI43 UniProtKB:Q66WT7	C		Seeded From UniProt	complete
colocalizes_with	GO:0032991	protein-containing complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107571 PANTHER:PTN000090155 RGD:2280 RGD:2281 RGD:620348 UniProtKB:P51636 UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000090213 RGD:2280 UniProtKB:Q03135	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000090155 RGD:2281	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 UniProtKB:Q03135	F		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 RGD:2280	P		Seeded From UniProt	complete
colocalizes_with	GO:0005925	focal adhesion	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107571 PANTHER:PTN000090155 RGD:2280 UniProtKB:P51636 UniProtKB:Q03135	C		Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 MGI:MGI:107570 PANTHER:PTN000851526 RGD:2280 RGD:2281 RGD:620348 UniProtKB:P33724 UniProtKB:P35431 UniProtKB:P51636 UniProtKB:P79132 UniProtKB:Q03135 UniProtKB:Q2KI43 UniProtKB:Q66WT7 UniProtKB:Q6RVA9	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000851526 UniProtKB:P51636 WB:WBGene00000301	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 RGD:2280	C		Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000851526 RGD:2280 RGD:2281 RGD:620348	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000851526 UniProtKB:P33724 UniProtKB:Q03135	F		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102709 PANTHER:PTN000090213 RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001258	negative regulation of cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000811	negative regulation of anoikis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000535	regulation of entry of bacterium into host cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903609	negative regulation of inward rectifier potassium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901380	negative regulation of potassium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900085	negative regulation of peptidyl-tyrosine autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900027	regulation of ruffle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098903	regulation of membrane repolarization during action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090398	cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072584	caveolin-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:21829547^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071455	cellular response to hyperoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071360	cellular response to exogenous dsRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070836	caveola assembly	PMID:12759260^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180372	P	occurs_in:(EMAPA:32743) occurs_in:(CL:0000071)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070836	caveola assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
enables	GO:0070320	inward rectifier potassium channel inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061099	negative regulation of protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060355	positive regulation of cell adhesion molecule production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060056	mammary gland involution	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	has_participant:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055074	calcium ion homeostasis	PMID:12651616^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2654177	P	has_participant:(EMAPA:36554)\|has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0052547	regulation of peptidase activity	PMID:17349656^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	regulates_o_occurs_in:(EMAPA:17337) regulates_o_occurs_in:(CL:0000746) has_regulation_target:(MGI:MGI:97009)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051899	membrane depolarization	PMID:17098833^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	occurs_in:(EMAPA:18613) occurs_in:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	PMID:8552590^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	PMID:11884617^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051001	negative regulation of nitric-oxide synthase activity	PMID:18951881^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154537	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051001	negative regulation of nitric-oxide synthase activity	PMID:16380094^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154537	P	regulates_o_occurs_in:(EMAPA:16105) has_regulation_target:(MGI:MGI:97362)	Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048550	negative regulation of pinocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:8552590^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046785	microtubule polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	PMID:12388746^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97762	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	PMID:12388746^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045907	positive regulation of vasoconstriction	PMID:11884617^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045807	positive regulation of endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:17416589^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16728) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:12927782^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:12388746^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17759)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:12388596^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:12138167^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:11784086^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:10787428^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846) part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:10197531^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045019	negative regulation of nitric oxide biosynthetic process	PMID:12388077^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	regulates_o_occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
	GO:0038016	insulin receptor internalization	PMID:27110488^[29]	ECO:0000315			P		Figure 5D-F: Overexpression of mutant mouse CAV-1 results in increased domain density of the insulin receptor, increased size of insulin receptor domains, and increased numbers of insulin receptors present on the plasma membrane, indicating a decrease in insulin receptor internalization with the nonfunctional protein.	complete CACAO 12293
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	PMID:12388746^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17759) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	PMID:12388746^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043409	negative regulation of MAPK cascade	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043407	negative regulation of MAP kinase activity	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043085	positive regulation of catalytic activity	PMID:17349656^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	regulates_o_occurs_in:(EMAPA:17337) regulates_o_occurs_in:(CL:0000746) has_regulation_target:(MGI:MGI:97009)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042632	cholesterol homeostasis	PMID:16603689^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	regulates_o_occurs_in:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	PMID:12388746^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042310	vasoconstriction	PMID:17098833^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042060	wound healing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
colocalizes_with	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
enables	GO:0033612	receptor serine/threonine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033484	nitric oxide homeostasis	PMID:12177436^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033344	cholesterol efflux	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033137	negative regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17416589^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11881 UniProtKB:Q61056 UniProtKB:Q9QUQ5	C	part_of:(EMAPA:16728) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:24013648^[32]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032570	response to progesterone	PMID:12388746^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032507	maintenance of protein location in cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032091	negative regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031623	receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:22792322^[33]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031295	T cell costimulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031116	positive regulation of microtubule polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030857	negative regulation of epithelial cell differentiation	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	occurs_in:(EMAPA:17760) results_in_acquisition_of_features_of:(CL:0000150)\|occurs_in(EMAPA:36566) results_in_acquisition_of_features_of:(CL:0000150)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030193	regulation of blood coagulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019915	lipid storage	PMID:11884617^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	occurs_in:(EMAPA:36499)\|occurs_in:(EMAPA:17759)	Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019217	regulation of fatty acid metabolic process	PMID:11884617^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019065	receptor-mediated endocytosis of virus by host cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
enables	GO:0016504	peptidase activator activity	PMID:17349656^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	F	occurs_in:(EMAPA:17337) occurs_in:(CL:0000746) has_regulation_target:(MGI:MGI:97009)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10460238^[34]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16731532^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11784086^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11316799^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010656	negative regulation of muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009968	negative regulation of signal transduction	PMID:9685399^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009967	positive regulation of signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009612	response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17202321^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154537	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:12388077^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008104	protein localization	PMID:17416589^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154537	P		Seeded From UniProt	complete
acts_upstream_of_negative_effect	GO:0007595	lactation	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007519	skeletal muscle tissue development	PMID:17200204^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	results_in_development_of:(EMAPA:32716)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006940	regulation of smooth muscle contraction	PMID:17098833^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	regulates_o_occurs_in:(EMAPA:18613) regulates_o_has_participant:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006940	regulation of smooth muscle contraction	PMID:16782699^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	regulates_o_occurs_in:(EMAPA:35783) regulates_o_has_participant:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:17098833^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	occurs_in:(EMAPA:18613) occurs_in:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:17416589^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154537	P	occurs_in:(EMAPA:35176) occurs_in:(CL:0000071)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006641	triglyceride metabolic process	PMID:11884617^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:10631317^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:11784086^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
colocalizes_with	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:9148942^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:9008709^[43]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:18054955^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:16513830^[45]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:12388746^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17759)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:11884617^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16728)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:24013648^[32]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41350	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8552590^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20724702^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17349656^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17339) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16782699^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35783) part_of:(CL:0000192)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16603689^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16138) part_of:(CL:0000235)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14600260^[47]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35578) part_of:(CL:0000515)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12832401^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12138167^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32686)\|part_of:(EMAPA:16105) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10787428^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:10787428^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:10787428^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0005778	peroxisomal membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003057	regulation of the force of heart contraction by chemical signal	PMID:18951881^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97362	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002931	response to ischemia	PMID:17293479^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180372	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0002080	acrosomal membrane	PMID:11784086^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002026	regulation of the force of heart contraction	PMID:16380094^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154537	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001960	negative regulation of cytokine-mediated signaling pathway	PMID:12388746^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	regulates_o_occurs_in:(EMAPA:17759) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001937	negative regulation of endothelial cell proliferation	PMID:11884617^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	regulates_o_occurs_in:(EMAPA:32692)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:16601228^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154537	P	occurs_in:(EMAPA:36500)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:16601228^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154537	P	occurs_in:(EMAPA:36500)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:12759260^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95516	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000188	inactivation of MAPK activity	PMID:12388077^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180364	P	regulates_o_occurs_in:(EMAPA:16105) regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2280	F		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03135	C		Seeded From UniProt	complete
involved_in	GO:0010952	positive regulation of peptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016504	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:2000535	regulation of entry of bacterium into host cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:1903609	negative regulation of inward rectifier potassium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:1901380	negative regulation of potassium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:1900085	negative regulation of peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:1900027	regulation of ruffle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0098903	regulation of membrane repolarization during action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0072584	caveolin-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0071455	cellular response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
enables	GO:0070320	inward rectifier potassium channel inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	F		Seeded From UniProt	complete
involved_in	GO:0061099	negative regulation of protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0060355	positive regulation of cell adhesion molecule production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	F		Seeded From UniProt	complete
involved_in	GO:0048550	negative regulation of pinocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	F		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	F		Seeded From UniProt	complete
involved_in	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
part_of	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
involved_in	GO:0030193	regulation of blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	F		Seeded From UniProt	complete
involved_in	GO:0019065	receptor-mediated endocytosis of virus by host cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	F		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03135 ensembl:ENSP00000339191	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015504	C		Seeded From UniProt	complete
involved_in	GO:0070836	caveola assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001612 InterPro:IPR015504	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006897	endocytosis	PMID:10373486^[51]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:10373486^[51]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0035	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Martin, S et al. (2012) Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model. PLoS ONE 7 e46242 PubMed GONUTS page
↑ Cohen, AW et al. (2005) Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue. Diabetes 54 679-86 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 Yang, KC et al. (2014) Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase. Circ Arrhythm Electrophysiol 7 701-10 PubMed GONUTS page
↑ Lee, H et al. (2002) Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. J. Biol. Chem. 277 34556-67 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Scherer, PE et al. (1996) Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc. Natl. Acad. Sci. U.S.A. 93 131-5 PubMed GONUTS page
↑ Scherer, PE et al. (1997) Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J. Biol. Chem. 272 29337-46 PubMed GONUTS page
↑ Bakhshi, FR et al. (2013) Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm Circ 3 816-30 PubMed GONUTS page
↑ ^8.0 ^8.1 Sundivakkam, PC et al. (2009) Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Am. J. Physiol., Cell Physiol. 296 C403-13 PubMed GONUTS page
↑ ^9.0 ^9.1 Chunhacha, P et al. (2012) Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells. Am. J. Physiol., Cell Physiol. 302 C1284-92 PubMed GONUTS page
↑ ^10.0 ^10.1 Galbiati, F et al. (2000) Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains. J. Biol. Chem. 275 23368-77 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Samarakoon, R et al. (2011) Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression. PLoS ONE 6 e22896 PubMed GONUTS page
↑ ^13.0 ^13.1 Woodman, SE et al. (2003) Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli. Am. J. Pathol. 162 2059-68 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 ^14.15 ^14.16 ^14.17 Park, DS et al. (2002) Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Mol. Biol. Cell 13 3416-30 PubMed GONUTS page
↑ Cao, G et al. (2003) Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am. J. Pathol. 162 1241-8 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Chow, AK et al. (2007) Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart. J. Mol. Cell. Cardiol. 42 896-901 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Adebiyi, A et al. (2007) Caveolin-1 abolishment attenuates the myogenic response in murine cerebral arteries. Am. J. Physiol. Heart Circ. Physiol. 292 H1584-92 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Razani, B et al. (2002) Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol. Cell. Biol. 22 2329-44 PubMed GONUTS page
↑ ^19.0 ^19.1 Wunderlich, C et al. (2008) Nitric oxide synthases are crucially involved in the development of the severe cardiomyopathy of caveolin-1 knockout mice. Biochem. Biophys. Res. Commun. 377 769-74 PubMed GONUTS page
↑ ^20.0 ^20.1 Wunderlich, C et al. (2006) Disruption of caveolin-1 leads to enhanced nitrosative stress and severe systolic and diastolic heart failure. Biochem. Biophys. Res. Commun. 340 702-8 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Murata, T et al. (2007) Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J. Biol. Chem. 282 16631-43 PubMed GONUTS page
↑ Rouvinski, A et al. (2003) Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem. Biophys. Res. Commun. 308 750-8 PubMed GONUTS page
↑ Marchand, S et al. (2002) Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts. J. Neurosci. 22 8891-901 PubMed GONUTS page
↑ ^24.0 ^24.1 Woodman, SE et al. (2002) Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. J. Biol. Chem. 277 38988-97 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Travis, AJ et al. (2001) Expression and localization of caveolin-1, and the presence of membrane rafts, in mouse and Guinea pig spermatozoa. Dev. Biol. 240 599-610 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Garver, WS et al. (2000) Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. J. Lipid Res. 41 673-87 PubMed GONUTS page
↑ Brückner, K et al. (1999) EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron 22 511-24 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Cohen, AW et al. (2003) Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am. J. Physiol., Cell Physiol. 284 C457-74 PubMed GONUTS page
↑ Boothe, T et al. (2016) Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells. Mol Metab 5 366-78 PubMed GONUTS page
↑ ^30.0 ^30.1 Frank, PG et al. (2006) Caveolin-1 and regulation of cellular cholesterol homeostasis. Am. J. Physiol. Heart Circ. Physiol. 291 H677-86 PubMed GONUTS page
↑ Zhao, YY et al. (2002) Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc. Natl. Acad. Sci. U.S.A. 99 11375-80 PubMed GONUTS page
↑ ^32.0 ^32.1 Ludwig, A et al. (2013) Molecular composition and ultrastructure of the caveolar coat complex. PLoS Biol. 11 e1001640 PubMed GONUTS page
↑ Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page
↑ Lu, C et al. (1999) A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus. J. Neurosci. 19 7317-25 PubMed GONUTS page
↑ Dai, FF et al. (2006) The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J. Biol. Chem. 281 21942-53 PubMed GONUTS page
↑ Gargalovic, P & Dory, L (2001) Caveolin-1 and caveolin-2 expression in mouse macrophages. High density lipoprotein 3-stimulated secretion and a lack of significant subcellular co-localization. J. Biol. Chem. 276 26164-70 PubMed GONUTS page
↑ Engelman, JA et al. (1998) Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. J. Biol. Chem. 273 20448-55 PubMed GONUTS page
↑ Costa, MJ et al. (2007) Reciprocal negative regulation between thyrotropin/3',5'-cyclic adenosine monophosphate-mediated proliferation and caveolin-1 expression in human and murine thyrocytes. Mol. Endocrinol. 21 921-32 PubMed GONUTS page
↑ Schubert, W et al. (2007) Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation. Am. J. Pathol. 170 316-33 PubMed GONUTS page
↑ ^40.0 ^40.1 El-Yazbi, AF et al. (2006) Caveolin-1 knockout alters beta-adrenoceptors function in mouse small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 291 G1020-30 PubMed GONUTS page
↑ Kogo, H & Fujimoto, T (2000) Caveolin-1 isoforms are encoded by distinct mRNAs. Identification Of mouse caveolin-1 mRNA variants caused by alternative transcription initiation and splicing. FEBS Lett. 465 119-23 PubMed GONUTS page
↑ Babitt, J et al. (1997) Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae. J. Biol. Chem. 272 13242-9 PubMed GONUTS page
↑ Parton, RG et al. (1997) Caveolin-3 associates with developing T-tubules during muscle differentiation. J. Cell Biol. 136 137-54 PubMed GONUTS page
↑ Horikawa, YT et al. (2008) Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 44 123-30 PubMed GONUTS page
↑ Lu, X et al. (2006) DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147 3123-32 PubMed GONUTS page
↑ Sharma, A et al. (2010) A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis. Arterioscler. Thromb. Vasc. Biol. 30 2196-204 PubMed GONUTS page
↑ Smythe, GM et al. (2003) A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes. J. Cell. Sci. 116 4739-49 PubMed GONUTS page
↑ Widberg, CH et al. (2003) Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. J. Biol. Chem. 278 35093-101 PubMed GONUTS page
↑ Jasmin, JF et al. (2007) Caveolin-1 deficiency increases cerebral ischemic injury. Circ. Res. 100 721-9 PubMed GONUTS page
↑ ^50.0 ^50.1 Sbaa, E et al. (2006) Caveolin plays a central role in endothelial progenitor cell mobilization and homing in SDF-1-driven postischemic vasculogenesis. Circ. Res. 98 1219-27 PubMed GONUTS page
↑ ^51.0 ^51.1 Das, K et al. (1999) The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo. J. Biol. Chem. 274 18721-8 PubMed GONUTS page

[PMID:23049990-1] 1.0 ^1.1 Martin, S et al. (2012) Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model. PLoS ONE 7 e46242 PubMed GONUTS page

[PMID:15734843-2] Cohen, AW et al. (2005) Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue. Diabetes 54 679-86 PubMed GONUTS page

[PMID:25017399-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 Yang, KC et al. (2014) Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase. Circ Arrhythm Electrophysiol 7 701-10 PubMed GONUTS page

[PMID:12091389-4] Lee, H et al. (2002) Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. J. Biol. Chem. 277 34556-67 PubMed GONUTS page

[PMID:8552590-5] 5.0 ^5.1 ^5.2 ^5.3 Scherer, PE et al. (1996) Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc. Natl. Acad. Sci. U.S.A. 93 131-5 PubMed GONUTS page

[PMID:9361015-6] Scherer, PE et al. (1997) Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J. Biol. Chem. 272 29337-46 PubMed GONUTS page

[PMID:25006397-7] Bakhshi, FR et al. (2013) Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm Circ 3 816-30 PubMed GONUTS page

[PMID:19052258-8] 8.0 ^8.1 Sundivakkam, PC et al. (2009) Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Am. J. Physiol., Cell Physiol. 296 C403-13 PubMed GONUTS page

[PMID:22277751-9] 9.0 ^9.1 Chunhacha, P et al. (2012) Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells. Am. J. Physiol., Cell Physiol. 302 C1284-92 PubMed GONUTS page

[PMID:10816572-10] 10.0 ^10.1 Galbiati, F et al. (2000) Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains. J. Biol. Chem. 275 23368-77 PubMed GONUTS page

[PMID:21873635-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21829547-12] Samarakoon, R et al. (2011) Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression. PLoS ONE 6 e22896 PubMed GONUTS page

[PMID:12759260-13] 13.0 ^13.1 Woodman, SE et al. (2003) Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli. Am. J. Pathol. 162 2059-68 PubMed GONUTS page

[PMID:12388746-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 ^14.15 ^14.16 ^14.17 Park, DS et al. (2002) Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Mol. Biol. Cell 13 3416-30 PubMed GONUTS page

[PMID:12651616-15] Cao, G et al. (2003) Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am. J. Pathol. 162 1241-8 PubMed GONUTS page

[PMID:17349656-16] 16.0 ^16.1 ^16.2 ^16.3 Chow, AK et al. (2007) Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart. J. Mol. Cell. Cardiol. 42 896-901 PubMed GONUTS page

[PMID:17098833-17] 17.0 ^17.1 ^17.2 ^17.3 Adebiyi, A et al. (2007) Caveolin-1 abolishment attenuates the myogenic response in murine cerebral arteries. Am. J. Physiol. Heart Circ. Physiol. 292 H1584-92 PubMed GONUTS page

[PMID:11884617-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Razani, B et al. (2002) Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol. Cell. Biol. 22 2329-44 PubMed GONUTS page

[PMID:18951881-19] 19.0 ^19.1 Wunderlich, C et al. (2008) Nitric oxide synthases are crucially involved in the development of the severe cardiomyopathy of caveolin-1 knockout mice. Biochem. Biophys. Res. Commun. 377 769-74 PubMed GONUTS page

[PMID:16380094-20] 20.0 ^20.1 Wunderlich, C et al. (2006) Disruption of caveolin-1 leads to enhanced nitrosative stress and severe systolic and diastolic heart failure. Biochem. Biophys. Res. Commun. 340 702-8 PubMed GONUTS page

[PMID:17416589-21] 21.0 ^21.1 ^21.2 ^21.3 Murata, T et al. (2007) Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J. Biol. Chem. 282 16631-43 PubMed GONUTS page

[PMID:12927782-22] Rouvinski, A et al. (2003) Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem. Biophys. Res. Commun. 308 750-8 PubMed GONUTS page

[PMID:12388596-23] Marchand, S et al. (2002) Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts. J. Neurosci. 22 8891-901 PubMed GONUTS page

[PMID:12138167-24] 24.0 ^24.1 Woodman, SE et al. (2002) Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. J. Biol. Chem. 277 38988-97 PubMed GONUTS page

[PMID:11784086-25] 25.0 ^25.1 ^25.2 ^25.3 Travis, AJ et al. (2001) Expression and localization of caveolin-1, and the presence of membrane rafts, in mouse and Guinea pig spermatozoa. Dev. Biol. 240 599-610 PubMed GONUTS page

[PMID:10787428-26] 26.0 ^26.1 ^26.2 ^26.3 Garver, WS et al. (2000) Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. J. Lipid Res. 41 673-87 PubMed GONUTS page

[PMID:10197531-27] Brückner, K et al. (1999) EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron 22 511-24 PubMed GONUTS page

[PMID:12388077-28] 28.0 ^28.1 ^28.2 Cohen, AW et al. (2003) Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am. J. Physiol., Cell Physiol. 284 C457-74 PubMed GONUTS page

[PMID:27110488-29] Boothe, T et al. (2016) Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells. Mol Metab 5 366-78 PubMed GONUTS page

[PMID:16603689-30] 30.0 ^30.1 Frank, PG et al. (2006) Caveolin-1 and regulation of cellular cholesterol homeostasis. Am. J. Physiol. Heart Circ. Physiol. 291 H677-86 PubMed GONUTS page

[PMID:12177436-31] Zhao, YY et al. (2002) Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc. Natl. Acad. Sci. U.S.A. 99 11375-80 PubMed GONUTS page

[PMID:24013648-32] 32.0 ^32.1 Ludwig, A et al. (2013) Molecular composition and ultrastructure of the caveolar coat complex. PLoS Biol. 11 e1001640 PubMed GONUTS page

[PMID:22792322-33] Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page

[PMID:10460238-34] Lu, C et al. (1999) A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus. J. Neurosci. 19 7317-25 PubMed GONUTS page

[PMID:16731532-35] Dai, FF et al. (2006) The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J. Biol. Chem. 281 21942-53 PubMed GONUTS page

[PMID:11316799-36] Gargalovic, P & Dory, L (2001) Caveolin-1 and caveolin-2 expression in mouse macrophages. High density lipoprotein 3-stimulated secretion and a lack of significant subcellular co-localization. J. Biol. Chem. 276 26164-70 PubMed GONUTS page

[PMID:9685399-37] Engelman, JA et al. (1998) Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. J. Biol. Chem. 273 20448-55 PubMed GONUTS page

[PMID:17202321-38] Costa, MJ et al. (2007) Reciprocal negative regulation between thyrotropin/3',5'-cyclic adenosine monophosphate-mediated proliferation and caveolin-1 expression in human and murine thyrocytes. Mol. Endocrinol. 21 921-32 PubMed GONUTS page

[PMID:17200204-39] Schubert, W et al. (2007) Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation. Am. J. Pathol. 170 316-33 PubMed GONUTS page

[PMID:16782699-40] 40.0 ^40.1 El-Yazbi, AF et al. (2006) Caveolin-1 knockout alters beta-adrenoceptors function in mouse small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 291 G1020-30 PubMed GONUTS page

[PMID:10631317-41] Kogo, H & Fujimoto, T (2000) Caveolin-1 isoforms are encoded by distinct mRNAs. Identification Of mouse caveolin-1 mRNA variants caused by alternative transcription initiation and splicing. FEBS Lett. 465 119-23 PubMed GONUTS page

[PMID:9148942-42] Babitt, J et al. (1997) Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae. J. Biol. Chem. 272 13242-9 PubMed GONUTS page

[PMID:9008709-43] Parton, RG et al. (1997) Caveolin-3 associates with developing T-tubules during muscle differentiation. J. Cell Biol. 136 137-54 PubMed GONUTS page

[PMID:18054955-44] Horikawa, YT et al. (2008) Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 44 123-30 PubMed GONUTS page

[PMID:16513830-45] Lu, X et al. (2006) DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147 3123-32 PubMed GONUTS page

[PMID:20724702-46] Sharma, A et al. (2010) A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis. Arterioscler. Thromb. Vasc. Biol. 30 2196-204 PubMed GONUTS page

[PMID:14600260-47] Smythe, GM et al. (2003) A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes. J. Cell. Sci. 116 4739-49 PubMed GONUTS page

[PMID:12832401-48] Widberg, CH et al. (2003) Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. J. Biol. Chem. 278 35093-101 PubMed GONUTS page

[PMID:17293479-49] Jasmin, JF et al. (2007) Caveolin-1 deficiency increases cerebral ischemic injury. Circ. Res. 100 721-9 PubMed GONUTS page

[PMID:16601228-50] 50.0 ^50.1 Sbaa, E et al. (2006) Caveolin plays a central role in endothelial progenitor cell mobilization and homing in SDF-1-driven postischemic vasculogenesis. Circ. Res. 98 1219-27 PubMed GONUTS page

[PMID:10373486-51] 51.0 ^51.1 Das, K et al. (1999) The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo. J. Biol. Chem. 274 18721-8 PubMed GONUTS page

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MOUSE:CAV1

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