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PMID:27110488
| Citation |
Boothe, T, Lim, GE, Cen, H, Skovsø, S, Piske, M, Li, SN, Nabi, IR, Gilon, P and Johnson, JD (2016) Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells. Mol Metab 5:366-78 |
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| Abstract |
The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to result in dysfunctional receptors. Our objective was to determine the trafficking route and molecular mechanisms of functional tagged insulin receptors and endogenous insulin receptors in pancreatic beta-cells. |
| Links |
PubMed PMC4837300 Online version:10.1016/j.molmet.2016.01.009 |
| Keywords |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0038016: insulin receptor internalization |
ECO:0000315: |
P |
Figure 5D-F: Overexpression of mutant mouse CAV-1 results in increased domain density of the insulin receptor, increased size of insulin receptor domains, and increased numbers of insulin receptors present on the plasma membrane, indicating a decrease in insulin receptor internalization with the nonfunctional protein. |
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Notes
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