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Scherer, PE, Okamoto, T, Chun, M, Nishimoto, I, Lodish, HF and Lisanti, MP (1996) Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc. Natl. Acad. Sci. U.S.A. 93:131-5
Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an approximately 20-kDa caveolin-related protein, caveolin-2, was identified through microsequencing of adipocyte-derived caveolin-enriched membranes; caveolin was retermed caveolin-1. Caveolins 1 and 2 are similar in most respects. mRNAs for both caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Caveolin-2 colocalizes with caveolin-1, indicating that caveolin-2 also localizes to caveolae. However, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell.
3T3 Cells; Adipocytes/chemistry; Amino Acid Sequence; Animals; Caveolin 1; Caveolins; Chickens; Fluorescent Antibody Technique, Indirect; GTP-Binding Proteins/metabolism; Gene Expression; Humans; Membrane Proteins/genetics; Mice; Molecular Sequence Data; Multigene Family; RNA, Messenger/genetics; Sequence Alignment; Sequence Homology, Amino Acid
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