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PMID:17200204
Citation |
Schubert, W, Sotgia, F, Cohen, AW, Capozza, F, Bonuccelli, G, Bruno, C, Minetti, C, Bonilla, E, Dimauro, S and Lisanti, MP (2007) Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation. Am. J. Pathol. 170:316-33 |
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Abstract |
Here, we examine the role of "non-muscle" caveolins (Cav-1 and Cav-2) in skeletal muscle biology. Our results indicate that skeletal muscle fibers from male Cav-1(-/-) and Cav-2(-/-) mice show striking abnormalities, such as tubular aggregates, mitochondrial proliferation/aggregation, and increased numbers of M-cadherin-positive satellite cells. Notably, these skeletal muscle defects were more pronounced with increasing age. Because Cav-2-deficient mice displayed normal expression levels of Cav-1, whereas Cav-1-null mice exhibited an almost complete deficiency in Cav-2, these skeletal muscle abnormalities seem to be due to loss of Cav-2. Thus, Cav-2(-/-) mice represent a novel animal model-and the first genetically well-defined mouse model-that can be used to study the pathogenesis of tubular aggregate formation, which remains a poorly understood age-related skeletal muscle abnormality. Finally, because Cav-1 and Cav-2 were not expressed within mature skeletal myofibers, our results indicate that development of these abnormalities probably originates in stem/precursor cells, such as satellite cells or myoblasts. Consistent with this hypothesis, skeletal muscle isolated from male Cav-3(-/-) mice did not show any of these abnormalities. As such, this is the first study linking stem cells with the genesis of these intriguing muscle defects. |
Links |
PubMed PMC1762679 Online version:10.2353/ajpath.2007.060687 |
Keywords |
Animals; Cadherins/biosynthesis; Caveolin 1/deficiency; Caveolin 1/genetics; Caveolin 2/deficiency; Caveolin 2/genetics; Disease Models, Animal; Electron Transport Complex IV/analysis; Genetic Predisposition to Disease; Male; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Mitochondria, Muscle/metabolism; Mitochondria, Muscle/ultrastructure; Muscle Fibers, Skeletal/metabolism; Muscle Fibers, Skeletal/ultrastructure; Muscle, Skeletal/abnormalities; Muscle, Skeletal/metabolism; Muscle, Skeletal/ultrastructure; Muscular Diseases/genetics; Muscular Diseases/metabolism; Muscular Diseases/pathology; Myoblasts/metabolism; Myoblasts/pathology |
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