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PMID:1087798
| Citation |
'Belokrylov, GA and Zhitnukhin, IuL (1976) [Effect of antibodies to rat and human cerebral cortex and white matter on heterologous T- and B-cells]. Zh. Mikrobiol. Epidemiol. Immunobiol. ':66-70 |
|---|---|
| Abstract |
A study was made of the cytotoxic and complement-fixation activity of the antisera to the cortex and white matter of the rat and human brain upon the mouse and rat thymus and bone marrow cells. The cytotoxicity test proved to be more sensitive and precise. Cytotoxins to rodent thymocytes were revealed on ly in the antisera against the human brain cortex; at the same time they were revealed both in the antisera against the cortex and against the white matter of the rat brain (much more was found in the former). The sera against the rat brain cortex lost their cytotoxicity after the exhaustion with the same antigen, but retained it when the exhaustion was carried out by the white matter. |
| Links | |
| Keywords |
Animals; Antibodies; B-Lymphocytes/immunology; Brain/immunology; Cerebral Cortex/immunology; Complement Fixation Tests; Cross Reactions; Cytotoxicity Tests, Immunologic; Humans; Mice; Rats; T-Lymphocytes/immunology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0032088: negative regulation of NF-kappaB transcription factor activity |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892: negative regulation of transcription, DNA-templated |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070513: death domain binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P19438 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097190: apoptotic signaling pathway |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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