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Category:GO:0070513 ! death domain binding

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DAG for GO:0070513id: GO:0070513

name: death domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]
comment: For binding to the death effector domain, consider instead the term 'death effector domain binding ; GO:0035877'.
is_a: GO:0019904 ! protein domain specific binding


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