HUMAN:CD28

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CD28
Protein Name(s)	T-cell-specific surface glycoprotein CD28 TP44
External Links
UniProt	P10747
EMBL	J02988 M37815 M37812 M37813 M37814 M37815 M37812 M37813 M37814 AJ295273 AF222341 AF222342 AF222343 AJ517504 EF064755 AK292986 AK313313 AC125238 CH471063 BC093698 BC112085 AF411057
CCDS	CCDS2361.1 CCDS58749.1
PIR	A39983
RefSeq	NP_001230006.1 NP_001230007.1 NP_006130.1
UniGene	Hs.443123
PDB	1YJD 3WA4
PDBsum	1YJD 3WA4
ProteinModelPortal	P10747
SMR	P10747
BioGrid	107378
DIP	DIP-6043N
IntAct	P10747
MINT	MINT-4656075
ChEMBL	CHEMBL5191
PhosphoSite	P10747
DMDM	115973
MaxQB	P10747
PaxDb	P10747
PRIDE	P10747
Ensembl	ENST00000324106 ENST00000374481 ENST00000458610
GeneID	940
KEGG	hsa:940
UCSC	uc002vah.4 uc010ftx.3 uc010zio.2
CTD	940
GeneCards	GC02P204535
HGNC	HGNC:1653
MIM	186760
neXtProt	NX_P10747
PharmGKB	PA26207
eggNOG	NOG48152
GeneTree	ENSGT00530000063873
HOVERGEN	HBG004094
InParanoid	P10747
KO	K06470
OMA	VNGNYSH
OrthoDB	EOG7W6WMJ
PhylomeDB	P10747
TreeFam	TF335679
Reactome	REACT_11139 REACT_147727 REACT_19183 REACT_19238 REACT_19358 REACT_75829
SignaLink	P10747
ChiTaRS	CD28
EvolutionaryTrace	P10747
GeneWiki	CD28
GenomeRNAi	940
NextBio	3894
PRO	PR:P10747
Proteomes	UP000005640
Bgee	P10747
CleanEx	HS_CD28
Genevestigator	P10747
GO	GO:0005829 GO:0009897 GO:0001772 GO:0005887 GO:0005886 GO:0015026 GO:0042802 GO:0002020 GO:0005070 GO:0097190 GO:0007166 GO:0042089 GO:0007173 GO:0038095 GO:0008543 GO:0006959 GO:0045087 GO:0045060 GO:0048011 GO:0048015 GO:0046641 GO:0002863 GO:0045086 GO:0048304 GO:0045840 GO:0009967 GO:0042102 GO:0045944 GO:0045727 GO:0045070 GO:0050690 GO:0045066 GO:0031295 GO:0050852 GO:0016032
Gene3D	2.60.40.10
InterPro	IPR008093 IPR013783 IPR013106
Pfam	PF07686
PRINTS	PR01717

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0042110	T cell activation	PMID:18337562^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05112	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:8617933^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	PMID:8617933^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	PMID:8617933^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:15067037^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23817958^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134) has_regulation_target:(UniProtKB:O00214) has_regulation_target:(UniProtKB:O00182)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23817958^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134) has_regulation_target:(UniProtKB:P05162) has_regulation_target:(UniProtKB:P17931) has_regulation_target:(UniProtKB:P56470) has_regulation_target:(UniProtKB:Q96DT0)	Seeded From UniProt	complete
involved_in	GO:0045066	regulatory T cell differentiation	PMID:18641304^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:12777399^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P78325	F		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	PMID:3159820^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:12028592^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:3875683^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045070	positive regulation of viral genome replication	PMID:7492435^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:3159820^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:3159820^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	PMID:19641626^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN002608477	P		Seeded From UniProt	complete
involved_in	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN000161013 UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN000161013 RGD:2299 UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN000161013 UniProtKB:P10747	P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN000161013 RGD:2299	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 MGI:MGI:88556 PANTHER:PTN002608477 UniProtKB:P10747 UniProtKB:P16410	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN002608477 RGD:2299 UniProtKB:P10747 UniProtKB:P16410	P		Seeded From UniProt	complete
part_of	GO:0098636	protein complex involved in cell adhesion	PMID:7544393^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:11390434^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11390434^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0048304	positive regulation of isotype switching to IgG isotypes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0046641	positive regulation of alpha-beta T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0045589	regulation of regulatory T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0045086	positive regulation of interleukin-2 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0045060	negative thymic T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	F		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	C		Seeded From UniProt	complete
involved_in	GO:0002863	positive regulation of inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	P		Seeded From UniProt	complete
part_of	GO:0001772	immunological synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31041 ensembl:ENSMUSP00000027165	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008093	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008093	C		Seeded From UniProt	complete
involved_in	GO:0042129	regulation of T cell proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040216	P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	PMID:8617933^[2] Reactome:R-HSA-389356	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:8717514^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:9784967^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042089	cytokine biosynthetic process	PMID:8717514^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015026	coreceptor activity	PMID:9784967^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:9784967^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	PMID:8717514^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9784967^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050690	regulation of defense response to virus by virus	Reactome:R-HSA-164939	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-389381 Reactome:R-HSA-389354 Reactome:R-HSA-389352 Reactome:R-HSA-389350 Reactome:R-HSA-389348 Reactome:R-HSA-389158 Reactome:R-HSA-388832 Reactome:R-HSA-388831 Reactome:R-HSA-388814 Reactome:R-HSA-388811 Reactome:R-HSA-388808 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-167637 Reactome:R-HSA-167633 Reactome:R-HSA-167630	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-167637	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Murooka, TT et al. (2008) CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood 111 4892-901 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Blotta, MH et al. (1996) Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J. Immunol. 156 3133-40 PubMed GONUTS page
↑ Mikolajczak, SA et al. (2004) The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. J. Exp. Med. 199 1025-31 PubMed GONUTS page
↑ ^4.0 ^4.1 Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page
↑ Zheng, Y et al. (2008) Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3. J. Immunol. 181 1683-91 PubMed GONUTS page
↑ Fourie, AM et al. (2003) Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. J. Biol. Chem. 278 30469-77 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Hara, T et al. (1985) Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen). J. Exp. Med. 161 1513-24 PubMed GONUTS page
↑ Kleijn, M & Proud, CG (2002) The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes. BMC Biochem. 3 11 PubMed GONUTS page
↑ Moretta, A et al. (1985) Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen-receptor complex. J. Exp. Med. 162 823-38 PubMed GONUTS page
↑ Smithgall, MD et al. (1995) Costimulation of CD4+ T cells via CD28 modulates human immunodeficiency virus type 1 infection and replication in vitro. AIDS Res. Hum. Retroviruses 11 885-92 PubMed GONUTS page
↑ Li, H & Liang, S (2009) Local network topology in human protein interaction data predicts functional association. PLoS ONE 4 e6410 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Fargeas, CA et al. (1995) Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182 667-75 PubMed GONUTS page
↑ ^14.0 ^14.1 Kirchgessner, H et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J. Exp. Med. 193 1269-84 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Lenschow, DJ et al. (1996) CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14 233-58 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Greenfield, EA et al. (1998) CD28/B7 costimulation: a review. Crit. Rev. Immunol. 18 389-418 PubMed GONUTS page

[PMID:18337562-1] Murooka, TT et al. (2008) CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood 111 4892-901 PubMed GONUTS page

[PMID:8617933-2] 2.0 ^2.1 ^2.2 ^2.3 Blotta, MH et al. (1996) Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J. Immunol. 156 3133-40 PubMed GONUTS page

[PMID:15067037-3] Mikolajczak, SA et al. (2004) The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. J. Exp. Med. 199 1025-31 PubMed GONUTS page

[PMID:23817958-4] 4.0 ^4.1 Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page

[PMID:18641304-5] Zheng, Y et al. (2008) Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3. J. Immunol. 181 1683-91 PubMed GONUTS page

[PMID:12777399-6] Fourie, AM et al. (2003) Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. J. Biol. Chem. 278 30469-77 PubMed GONUTS page

[PMID:3159820-7] 7.0 ^7.1 ^7.2 Hara, T et al. (1985) Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen). J. Exp. Med. 161 1513-24 PubMed GONUTS page

[PMID:12028592-8] Kleijn, M & Proud, CG (2002) The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes. BMC Biochem. 3 11 PubMed GONUTS page

[PMID:3875683-9] Moretta, A et al. (1985) Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen-receptor complex. J. Exp. Med. 162 823-38 PubMed GONUTS page

[PMID:7492435-10] Smithgall, MD et al. (1995) Costimulation of CD4+ T cells via CD28 modulates human immunodeficiency virus type 1 infection and replication in vitro. AIDS Res. Hum. Retroviruses 11 885-92 PubMed GONUTS page

[PMID:19641626-11] Li, H & Liang, S (2009) Local network topology in human protein interaction data predicts functional association. PLoS ONE 4 e6410 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7544393-13] Fargeas, CA et al. (1995) Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182 667-75 PubMed GONUTS page

[PMID:11390434-14] 14.0 ^14.1 Kirchgessner, H et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J. Exp. Med. 193 1269-84 PubMed GONUTS page

[PMID:8717514-15] 15.0 ^15.1 ^15.2 Lenschow, DJ et al. (1996) CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14 233-58 PubMed GONUTS page

[PMID:9784967-16] 16.0 ^16.1 ^16.2 ^16.3 Greenfield, EA et al. (1998) CD28/B7 costimulation: a review. Crit. Rev. Immunol. 18 389-418 PubMed GONUTS page

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HUMAN:CD28

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