HUMAN:BAK

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BAK1 (synonyms: BAK, BCL2L7, CDN1)
Protein Name(s)	Bcl-2 homologous antagonist/killer Apoptosis regulator BAK Bcl-2-like protein 7 Bcl2-L-7
External Links
UniProt	Q16611
EMBL	X84213 U23765 U16811 AY260471 CR457419 Z93017 CH471081 CH471081 BC004431 BC110337 D88397
CCDS	CCDS4781.1
PIR	S58873
RefSeq	NP_001179.1
UniGene	Hs.485139
PDB	1BXL 2IMS 2IMT 2JBY 2JCN 2M5B 2XPX 2YV6 3I1H 3QBR 4D2L 4U2U 4U2V
PDBsum	1BXL 2IMS 2IMT 2JBY 2JCN 2M5B 2XPX 2YV6 3I1H 3QBR 4D2L 4U2U 4U2V
ProteinModelPortal	Q16611
SMR	Q16611
BioGrid	107054
DIP	DIP-935N
IntAct	Q16611
MINT	MINT-96576
STRING	9606.ENSP00000363591
ChEMBL	CHEMBL5609
TCDB	1.A.21.1.3
PhosphoSite	Q16611
DMDM	2493274
MaxQB	Q16611
PaxDb	Q16611
PRIDE	Q16611
DNASU	578
Ensembl	ENST00000374467 ENST00000442998
GeneID	578
KEGG	hsa:578
UCSC	uc003oer.3
CTD	578
GeneCards	GC06M033541
HGNC	HGNC:949
HPA	CAB005029
MIM	600516
neXtProt	NX_Q16611
PharmGKB	PA25253
eggNOG	NOG145601
GeneTree	ENSGT00530000062935
HOGENOM	HOG000006521
HOVERGEN	HBG002674
InParanoid	Q16611
KO	K14021
OMA	FQAMLQH
OrthoDB	EOG70GMGD
PhylomeDB	Q16611
TreeFam	TF315834
Reactome	REACT_707
EvolutionaryTrace	Q16611
GeneWiki	Bcl-2_homologous_antagonist_killer
GenomeRNAi	578
NextBio	2359
PRO	PR:Q16611
Proteomes	UP000005640
Bgee	Q16611
CleanEx	HS_BAK1
ExpressionAtlas	Q16611
Genevestigator	Q16611
GO	GO:0005829 GO:0005783 GO:0031307 GO:0005741 GO:0005739 GO:0046930 GO:0042802 GO:0046872 GO:0046982 GO:0042803 GO:0097202 GO:0008635 GO:0007568 GO:0006915 GO:1902262 GO:0097190 GO:0001783 GO:0001782 GO:0002352 GO:0001974 GO:0007420 GO:0008283 GO:0071260 GO:0034644 GO:0031018 GO:0032469 GO:0010248 GO:0097192 GO:0044346 GO:0097193 GO:0008630 GO:0070059 GO:0035108 GO:0008053 GO:0002262 GO:0008285 GO:0032471 GO:0010629 GO:0033137 GO:0031100 GO:0043065 GO:0010524 GO:1900103 GO:1901030 GO:0045862 GO:0090200 GO:0048597 GO:0051726 GO:0046902 GO:0051881 GO:0043497 GO:0043496 GO:0001836 GO:0042493 GO:0045471 GO:0009620 GO:0010332 GO:0042542 GO:0010046 GO:0014070 GO:0010225 GO:0070242 GO:0060068
InterPro	IPR026308 IPR002475 IPR020717 IPR020726 IPR020728 IPR026298
PANTHER	PTHR11256 PTHR11256:SF41
Pfam	PF00452
PRINTS	PR01862
PROSITE	PS50062 PS01080 PS01258 PS01259

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005741	mitochondrial outer membrane	PMID:29531808^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097145	BAK complex	PMID:23028632^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:23028632^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:23028632^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08734	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:25296756^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21796	F		Seeded From UniProt	complete
involved_in	GO:0097202	activation of cysteine-type endopeptidase activity	PMID:18387192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	PMID:21041309^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045862	positive regulation of proteolysis	PMID:18387192^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21041309^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16611	F		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08734	P		Seeded From UniProt	complete
part_of	GO:0031307	integral component of mitochondrial outer membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08734	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:21041309^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O08734	P		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:16199525^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	PMID:9843949^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0046930	pore complex	PMID:9843949^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	PMID:9843949^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043497	regulation of protein heterodimerization activity	PMID:9111042^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043496	regulation of protein homodimerization activity	PMID:9111042^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	PMID:9843949^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:9843949^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:9843949^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	PMID:16645094^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(GO:0005789)	Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:15901672^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10837489^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07820	F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:17289999^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:15901672^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:7715731^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:108052 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 UniProtKB:Q07820	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2199 RGD:2200 RGD:620525 RGD:620621 RGD:620717 RGD:621635 RGD:70984 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q07820 UniProtKB:Q16611 UniProtKB:Q92843 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-030825-1 ZFIN:ZDB-GENE-051012-1	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330841 MGI:MGI:1858494 MGI:MGI:99702 PANTHER:PTN000135648 RGD:621635 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q16611	F		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029131 MGI:MGI:101769 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648	P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2200 UniProtKB:P10415 UniProtKB:Q07817 WB:WBGene00000423	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23782464^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16611	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17446862^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16611	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16439990^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16611	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:15901672^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16611	F		Seeded From UniProt	complete
involved_in	GO:1902262	apoptotic process involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0070242	thymocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0060068	vagina development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0048872	homeostasis of number of cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0048597	post-embryonic camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0044346	fibroblast apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	C		Seeded From UniProt	complete
part_of	GO:0031307	integral component of mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	C		Seeded From UniProt	complete
involved_in	GO:0010524	positive regulation of calcium ion transport into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0010046	response to mycotoxin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0009620	response to fungus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0008053	mitochondrial fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	C		Seeded From UniProt	complete
involved_in	GO:0002352	B cell negative selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0002262	myeloid cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0001783	B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0001782	B cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0001776	leukocyte homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08734 ensembl:ENSMUSP00000077757	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
enables	GO:0051400	BH domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	F		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	F		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	F		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	F		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	C		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
involved_in	GO:0010225	response to UV-C	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JK59 ensembl:ENSRNOP00000000576	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020717 InterPro:IPR020726 InterPro:IPR020728 InterPro:IPR026298 InterPro:IPR036834	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026308	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:22934019^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	PMID:22013210^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903896	positive regulation of IRE1-mediated unfolded protein response	PMID:22013210^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:18309324^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Reactome:R-HSA-111452	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	Reactome:R-HSA-168848 Reactome:R-HSA-139895 Reactome:R-HSA-114263	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kuriyama, S et al. (2018) PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. Cell Death Discov 4 11 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Fujikane, R et al. (2012) The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine. PLoS ONE 7 e44817 PubMed GONUTS page
↑ Li, L et al. (2014) Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. J. Biol. Chem. 289 32628-38 PubMed GONUTS page
↑ ^4.0 ^4.1 Ketteler, R et al. (2008) A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Genome Biol. 9 R64 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Du, H et al. (2011) BH3 domains other than Bim and Bid can directly activate Bax/Bak. J. Biol. Chem. 286 491-501 PubMed GONUTS page
↑ Tan, KO et al. (2005) MAP-1 is a mitochondrial effector of Bax. Proc. Natl. Acad. Sci. U.S.A. 102 14623-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Narita, M et al. (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 14681-6 PubMed GONUTS page
↑ ^8.0 ^8.1 Diaz, JL et al. (1997) A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members. J. Biol. Chem. 272 11350-5 PubMed GONUTS page
↑ Hetz, C et al. (2006) Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312 572-6 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Willis, SN et al. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 19 1294-305 PubMed GONUTS page
↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
↑ Bae, J et al. (2000) MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J. Biol. Chem. 275 25255-61 PubMed GONUTS page
↑ Willis, SN et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315 856-9 PubMed GONUTS page
↑ Kiefer, MC et al. (1995) Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature 374 736-9 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Azad, A & Storey, A (2013) BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove. Mol. Cancer 12 65 PubMed GONUTS page
↑ Maiuri, MC et al. (2007) Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 26 2527-39 PubMed GONUTS page
↑ Postigo, A et al. (2006) Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis. Cell Death Differ. 13 1651-62 PubMed GONUTS page
↑ Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page
↑ ^20.0 ^20.1 Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page
↑ Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

[PMID:29531808-1] Kuriyama, S et al. (2018) PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. Cell Death Discov 4 11 PubMed GONUTS page

[PMID:23028632-2] 2.0 ^2.1 ^2.2 Fujikane, R et al. (2012) The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine. PLoS ONE 7 e44817 PubMed GONUTS page

[PMID:25296756-3] Li, L et al. (2014) Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. J. Biol. Chem. 289 32628-38 PubMed GONUTS page

[PMID:18387192-4] 4.0 ^4.1 Ketteler, R et al. (2008) A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Genome Biol. 9 R64 PubMed GONUTS page

[PMID:21041309-5] 5.0 ^5.1 ^5.2 Du, H et al. (2011) BH3 domains other than Bim and Bid can directly activate Bax/Bak. J. Biol. Chem. 286 491-501 PubMed GONUTS page

[PMID:16199525-6] Tan, KO et al. (2005) MAP-1 is a mitochondrial effector of Bax. Proc. Natl. Acad. Sci. U.S.A. 102 14623-8 PubMed GONUTS page

[PMID:9843949-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Narita, M et al. (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 14681-6 PubMed GONUTS page

[PMID:9111042-8] 8.0 ^8.1 Diaz, JL et al. (1997) A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members. J. Biol. Chem. 272 11350-5 PubMed GONUTS page

[PMID:16645094-9] Hetz, C et al. (2006) Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312 572-6 PubMed GONUTS page

[PMID:15901672-10] 10.0 ^10.1 ^10.2 Willis, SN et al. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 19 1294-305 PubMed GONUTS page

[PMID:19593445-11] Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page

[PMID:10837489-12] Bae, J et al. (2000) MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J. Biol. Chem. 275 25255-61 PubMed GONUTS page

[PMID:17289999-13] Willis, SN et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315 856-9 PubMed GONUTS page

[PMID:7715731-14] Kiefer, MC et al. (1995) Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature 374 736-9 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23782464-16] Azad, A & Storey, A (2013) BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove. Mol. Cancer 12 65 PubMed GONUTS page

[PMID:17446862-17] Maiuri, MC et al. (2007) Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 26 2527-39 PubMed GONUTS page

[PMID:16439990-18] Postigo, A et al. (2006) Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis. Cell Death Differ. 13 1651-62 PubMed GONUTS page

[PMID:22934019-19] Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page

[PMID:22013210-20] 20.0 ^20.1 Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page

[PMID:18309324-21] Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

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HUMAN:BAK

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