CHICK:SHH

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	SHH
Protein Name(s)	Sonic hedgehog protein SHH Sonic hedgehog protein N-product Sonic hedgehog protein C-product
External Links
UniProt	Q91035
EMBL	L28099
PIR	A49424
RefSeq	NP_990152.1
UniGene	Gga.345
ProteinModelPortal	Q91035
SMR	Q91035
STRING	9031.ENSGALP00000010292
MEROPS	C46.002
PaxDb	Q91035
PRIDE	Q91035
GeneID	395615
KEGG	gga:395615
CTD	6469
eggNOG	NOG250647
HOGENOM	HOG000233428
HOVERGEN	HBG005480
InParanoid	Q91035
KO	K11988
PhylomeDB	Q91035
NextBio	20815688
PRO	PR:Q91035
Proteomes	UP000000539
GO	GO:0005576 GO:0005615 GO:0005886 GO:0005509 GO:0016015 GO:0008233 GO:0008270 GO:0009952 GO:0097190 GO:0001709 GO:0060573 GO:0007267 GO:0042733 GO:0030326 GO:0009880 GO:0060059 GO:0048877 GO:0016539 GO:0043066 GO:0030514 GO:0003408 GO:0021631 GO:0009949 GO:0009951 GO:0061075 GO:0045880 GO:0060785 GO:0060786 GO:0010468 GO:0032526 GO:0003406 GO:0009888
Gene3D	2.170.16.10 3.30.1380.10
InterPro	IPR001657 IPR028992 IPR009045 IPR000320 IPR001767 IPR003586 IPR003587 IPR006141
Pfam	PF01085 PF01079
PIRSF	PIRSF009400
PRINTS	PR00632
SMART	SM00305 SM00306
SUPFAM	SSF51294 SSF55166
PROSITE	PS50817

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0023052	signaling	PMID:10500184^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097264	self proteolysis	PMID:7891723^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0009949	polarity specification of anterior/posterior axis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62226	P		Seeded From UniProt	complete
involved_in	GO:0061075	positive regulation of neural retina development	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060785	regulation of apoptosis involved in tissue homeostasis	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000966)	Seeded From UniProt	complete
involved_in	GO:0060059	embryonic retina morphogenesis in camera-type eye	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048877	homeostasis of number of retina cells	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0016855)	Seeded From UniProt	complete
involved_in	GO:0021631	optic nerve morphogenesis	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009951	polarity specification of dorsal/ventral axis	PMID:11336495^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009888	tissue development	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0016855)	Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003408	optic cup formation involved in camera-type eye development	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003406	retinal pigment epithelium development	PMID:11336495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001709	cell fate determination	PMID:11336495^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:8269518^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	PMID:8269518^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016015	morphogen activity	PMID:8269518^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:8269518^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:8269518^[4]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000177	regulation of neural precursor cell proliferation	PMID:15759272^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003065)	Seeded From UniProt	complete
involved_in	GO:0090269	fibroblast growth factor production	PMID:10524628^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090269	fibroblast growth factor production	PMID:9187149^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	PMID:15746914^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060591	chondroblast differentiation	PMID:10976986^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021513	spinal cord dorsal/ventral patterning	PMID:15746914^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021508	floor plate formation	PMID:15746914^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10976986^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003430	growth plate cartilage chondrocyte growth	PMID:9427387^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001895	retina homeostasis	PMID:15759272^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003065)	Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q15465	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q15465	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q15465	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q15465	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016015	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001767	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000320 InterPro:IPR001657	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001657	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001767	F		Seeded From UniProt	complete
involved_in	GO:0016539	intein-mediated protein splicing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006141	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:8951071^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0005417) has_regulation_target:(UniProtKB:Q05438) has_regulation_target:(UniProtKB:F1NTD3) has_regulation_target:(UniProtKB:F1NIC3)	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:9268735^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030166	proteoglycan biosynthetic process	PMID:10976986^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010770	positive regulation of cell morphogenesis involved in differentiation	PMID:10976986^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010694	positive regulation of alkaline phosphatase activity	PMID:9268735^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:10976986^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9268735^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:10500184^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060786	regulation of cell differentiation involved in tissue homeostasis	PMID:11336495^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060573	cell fate specification involved in pattern specification	PMID:11336495^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(UBERON:0001782)	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Tsukui, T et al. (1999) Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc. Natl. Acad. Sci. U.S.A. 96 11376-81 PubMed GONUTS page
↑ Bumcrot, DA et al. (1995) Proteolytic processing yields two secreted forms of sonic hedgehog. Mol. Cell. Biol. 15 2294-303 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 Zhang, XM & Yang, XJ (2001) Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. Dev. Biol. 233 271-90 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Riddle, RD et al. (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75 1401-16 PubMed GONUTS page
↑ ^5.0 ^5.1 Moshiri, A et al. (2005) Sonic hedgehog regulates proliferation of the retinal ciliary marginal zone in posthatch chicks. Dev. Dyn. 233 66-75 PubMed GONUTS page
↑ Zúñiga, A et al. (1999) Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature 401 598-602 PubMed GONUTS page
↑ Ohuchi, H et al. (1997) The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124 2235-44 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Bourikas, D et al. (2005) Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord. Nat. Neurosci. 8 297-304 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Enomoto-Iwamoto, M et al. (2000) Hedgehog proteins stimulate chondrogenic cell differentiation and cartilage formation. J. Bone Miner. Res. 15 1659-68 PubMed GONUTS page
↑ Stott, NS & Chuong, CM (1997) Dual action of sonic hedgehog on chondrocyte hypertrophy: retrovirus mediated ectopic sonic hedgehog expression in limb bud micromass culture induces novel cartilage nodules that are positive for alkaline phosphatase and type X collagen. J. Cell. Sci. 110 ( Pt 21) 2691-701 PubMed GONUTS page
↑ Kawakami, Y et al. (1996) BMP signaling during bone pattern determination in the developing limb. Development 122 3557-66 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Nakamura, T et al. (1997) Induction of osteogenic differentiation by hedgehog proteins. Biochem. Biophys. Res. Commun. 237 465-9 PubMed GONUTS page

[PMID:10500184-1] 1.0 ^1.1 Tsukui, T et al. (1999) Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc. Natl. Acad. Sci. U.S.A. 96 11376-81 PubMed GONUTS page

[PMID:7891723-2] Bumcrot, DA et al. (1995) Proteolytic processing yields two secreted forms of sonic hedgehog. Mol. Cell. Biol. 15 2294-303 PubMed GONUTS page

[PMID:11336495-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 Zhang, XM & Yang, XJ (2001) Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. Dev. Biol. 233 271-90 PubMed GONUTS page

[PMID:8269518-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Riddle, RD et al. (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75 1401-16 PubMed GONUTS page

[PMID:15759272-5] 5.0 ^5.1 Moshiri, A et al. (2005) Sonic hedgehog regulates proliferation of the retinal ciliary marginal zone in posthatch chicks. Dev. Dyn. 233 66-75 PubMed GONUTS page

[PMID:10524628-6] Zúñiga, A et al. (1999) Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature 401 598-602 PubMed GONUTS page

[PMID:9187149-7] Ohuchi, H et al. (1997) The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124 2235-44 PubMed GONUTS page

[PMID:15746914-8] 8.0 ^8.1 ^8.2 Bourikas, D et al. (2005) Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord. Nat. Neurosci. 8 297-304 PubMed GONUTS page

[PMID:10976986-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Enomoto-Iwamoto, M et al. (2000) Hedgehog proteins stimulate chondrogenic cell differentiation and cartilage formation. J. Bone Miner. Res. 15 1659-68 PubMed GONUTS page

[PMID:9427387-10] Stott, NS & Chuong, CM (1997) Dual action of sonic hedgehog on chondrocyte hypertrophy: retrovirus mediated ectopic sonic hedgehog expression in limb bud micromass culture induces novel cartilage nodules that are positive for alkaline phosphatase and type X collagen. J. Cell. Sci. 110 ( Pt 21) 2691-701 PubMed GONUTS page

[PMID:8951071-11] Kawakami, Y et al. (1996) BMP signaling during bone pattern determination in the developing limb. Development 122 3557-66 PubMed GONUTS page

[PMID:9268735-12] 12.0 ^12.1 ^12.2 Nakamura, T et al. (1997) Induction of osteogenic differentiation by hedgehog proteins. Biochem. Biophys. Res. Commun. 237 465-9 PubMed GONUTS page

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CHICK:SHH

Contents

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