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MOUSE:CD5

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Cd5 (synonyms: Ly-1)
Protein Name(s) T-cell surface glycoprotein CD5

Lymphocyte antigen 1 Ly-1 Lyt-1

External Links
UniProt P13379
EMBL M15177
U09204
CCDS CCDS29586.1
PIR A29079
RefSeq NP_031676.3
UniGene Mm.779
ProteinModelPortal P13379
SMR P13379
PhosphoSite P13379
PaxDb P13379
PRIDE P13379
Ensembl ENSMUST00000025571
GeneID 12507
KEGG mmu:12507
UCSC uc008gqv.1
CTD 921
MGI MGI:88340
eggNOG NOG86650
HOGENOM HOG000111490
HOVERGEN HBG005286
InParanoid P13379
KO K06455
OMA MSFHRNH
OrthoDB EOG7TF792
PhylomeDB P13379
TreeFam TF329295
NextBio 281478
PRO PR:P13379
Proteomes UP000000589
Bgee P13379
CleanEx MM_CD5
ExpressionAtlas P13379
Genevestigator P13379
GO GO:0009897
GO:0016021
GO:0005044
GO:0097190
GO:0031295
Gene3D 3.10.250.10
InterPro IPR001190
IPR017448
IPR003566
Pfam PF00530
PRINTS PR00258
PR01409
SMART SM00202
SUPFAM SSF56487
PROSITE PS50287

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0031295

T cell costimulation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88340
PANTHER:PTN002499882

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002499882
UniProtKB:P06127

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097190

apoptotic signaling pathway

PMID:10429671[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0044214

spanning component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2309

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031295

T cell costimulation

PMID:10429671[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:9208839[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:7538697[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:7477353[5]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16138)
  • part_of:(CL:0000236)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:6610701[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:22732588[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:17941951[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:17357106[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:14662849[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P06127

C

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005044

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06127
ensembl:ENSP00000342681

C

Seeded From UniProt

complete

enables

GO:0005044

scavenger receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001190

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001190
InterPro:IPR003566
InterPro:IPR017448
InterPro:IPR036772

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 Kishimoto, H & Sprent, J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190 65-73 PubMed GONUTS page
  3. Wiest, DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6 663-71 PubMed GONUTS page
  4. Bendelac, A et al. (1995) CD1 recognition by mouse NK1+ T lymphocytes. Science 268 863-5 PubMed GONUTS page
  5. Cheng, AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378 303-6 PubMed GONUTS page
  6. Davidson, WF et al. (1984) Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J. Immunol. 133 1048-56 PubMed GONUTS page
  7. Lesourne, R et al. (2012) Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J. Immunol. 189 1154-61 PubMed GONUTS page
  8. Scaglione, BJ et al. (2007) Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model. Br. J. Haematol. 139 645-57 PubMed GONUTS page
  9. Ling, KW et al. (2007) GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur. J. Immunol. 37 1043-52 PubMed GONUTS page
  10. Kretschmer, K et al. (2003) The selection of marginal zone B cells differs from that of B-1a cells. J. Immunol. 171 6495-501 PubMed GONUTS page