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MOUSE:LEUK

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Spn
Protein Name(s) Leukosialin

B-cell differentiation antigen LP-3 Leukocyte sialoglycoprotein Lymphocyte antigen 48 Ly-48 Sialophorin

External Links
UniProt P15702
EMBL X17018
X52609
S70677
M30693
CCDS CCDS21858.1
PIR A43545
RefSeq NP_001032899.1
NP_033285.1
XP_006507585.1
UniGene Mm.283714
PDB 2EMS
PDBsum 2EMS
ProteinModelPortal P15702
SMR P15702
STRING 10090.ENSMUSP00000049534
iPTMnet P15702
PhosphoSitePlus P15702
EPD P15702
PaxDb P15702
PeptideAtlas P15702
PRIDE P15702
Ensembl ENSMUST00000049931
ENSMUST00000143713
GeneID 20737
KEGG mmu:20737
UCSC uc009juh.2
CTD 6693
MGI MGI:98384
eggNOG ENOG410J161
ENOG410YXQE
GeneTree ENSGT00390000017626
HOGENOM HOG000294199
HOVERGEN HBG006258
InParanoid P15702
KO K06477
OMA GPPLTMA
OrthoDB EOG091G0MEV
PhylomeDB P15702
TreeFam TF337688
Reactome [www.reactome.org/content/detail/R-MMU-202733 R-MMU-202733]
[www.reactome.org/content/detail/R-MMU-210991 R-MMU-210991]
EvolutionaryTrace P15702
PRO PR:P15702
Proteomes UP000000589
Bgee ENSMUSG00000051457
CleanEx MM_SPN
ExpressionAtlas P15702
Genevisible P15702
GO GO:0005604
GO:0009986
GO:0009897
GO:0070062
GO:0005615
GO:0005887
GO:0016020
GO:0001931
GO:0097190
GO:0007166
GO:0042742
GO:0007162
GO:0050868
GO:0042130
GO:0001808
GO:0045060
GO:0001934
GO:0042102
GO:0042535
GO:0050688
GO:0050776
GO:0001562
GO:0031295

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001931

uropod

PMID:24250818[1]

ECO:0000314

C

Organism: Homo Sapiens Protein: Leukosialin Figure 4 B) PKCθ regulates MTOC and CD43 localization to uropods

complete
CACAO 12495

part_of

GO:0005902

microvillus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13838

C

Seeded From UniProt

complete

involved_in

GO:0032609

interferon-gamma production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16150

P

Seeded From UniProt

complete

involved_in

GO:0002296

T-helper 1 cell lineage commitment

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16150

P

Seeded From UniProt

complete

involved_in

GO:2000404

regulation of T cell migration

PMID:21289089[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0001931

uropod

PMID:21289089[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050901

leukocyte tethering or rolling

PMID:26700769[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

PMID:17638845[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000406

positive regulation of T cell migration

PMID:17638845[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031072

heat shock protein binding

PMID:20633027[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:A0A0H3LCC3

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097190

apoptotic signaling pathway

PMID:10429671[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071594

thymocyte aggregation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3750

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050868

negative regulation of T cell activation

PMID:9645617[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050852

T cell receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3750

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050776

regulation of immune response

PMID:9645617[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050776

regulation of immune response

PMID:7566153[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050688

regulation of defense response to virus

PMID:7566153[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045060

negative thymic T cell selection

PMID:10429671[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042742

defense response to bacterium

PMID:10899905[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042742

defense response to bacterium

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16150

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

PMID:10899905[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16150

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042130

negative regulation of T cell proliferation

PMID:9645617[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042130

negative regulation of T cell proliferation

PMID:7566153[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042130

negative regulation of T cell proliferation

PMID:15117976[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042102

positive regulation of T cell proliferation

PMID:7790813[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042102

positive regulation of T cell proliferation

PMID:11380685[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032609

interferon-gamma production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16150

P

Seeded From UniProt

complete

part_of

GO:0032154

cleavage furrow

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3750

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031295

T cell costimulation

PMID:7790813[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031295

T cell costimulation

PMID:11380685[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031295

T cell costimulation

PMID:10429671[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031072

heat shock protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16150

F

Seeded From UniProt

complete

enables

GO:0030544

Hsp70 protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16150

F

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3750

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3750

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3750

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16150

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3750

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:9645617[7]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:8920854[13]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000826)|part_of:(CL:0000817)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:7795661[14]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000236)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:7790813[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:7566153[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:7514104[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:7477353[16]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32760)
  • part_of:(CL:0000236)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:15843532[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:15117976[10]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:14635057[18]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000624)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:11728336[19]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:11380685[12]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000542)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:10943842[20]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16332)
  • part_of:(CL:0000081)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007166

cell surface receptor signaling pathway

PMID:7790813[11]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007162

negative regulation of cell adhesion

PMID:7566153[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007162

negative regulation of cell adhesion

PMID:11828253[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007162

negative regulation of cell adhesion

PMID:11937524[22]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_has_participant:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3750

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:11937524[22]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:11728336[19]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16150

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

PMID:7514104[15]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:28251)|part_of:(EMAPA:32689)|part_of:(EMAPA:29917)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002296

T-helper 1 cell lineage commitment

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16150

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

PMID:20360400[23]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1314872

P

regulates_o_has_input:(MGI:MGI:103036)

Seeded From UniProt

complete

part_of

GO:0001931

uropod

PMID:11937524[22]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0001931

uropod

PMID:11728336[19]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001808

negative regulation of type IV hypersensitivity

PMID:9645617[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001562

response to protozoan

PMID:11994475[24]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038829

F

Seeded From UniProt

complete

involved_in

GO:0032609

interferon-gamma production

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038829

P

Seeded From UniProt

complete

involved_in

GO:0050863

regulation of T cell activation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038829

P

Seeded From UniProt

complete

involved_in

GO:2000404

regulation of T cell migration

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038829

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0293

C

Seeded From UniProt

complete

part_of

GO:0001931

uropod

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0141

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Cannon, JL et al. (2013) PKCθ regulates T cell motility via ezrin-radixin-moesin localization to the uropod. PLoS ONE 8 e78940 PubMed GONUTS page
  2. 2.0 2.1 Cannon, JL et al. (2011) CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Mol. Biol. Cell 22 954-63 PubMed GONUTS page
  3. Velázquez, F et al. (2016) CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J. Immunol. 196 1305-1316 PubMed GONUTS page
  4. 4.0 4.1 Mody, PD et al. (2007) Signaling through CD43 regulates CD4 T-cell trafficking. Blood 110 2974-82 PubMed GONUTS page
  5. Hickey, TB et al. (2010) Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface. Cell. Microbiol. 12 1634-47 PubMed GONUTS page
  6. 6.0 6.1 6.2 Kishimoto, H & Sprent, J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190 65-73 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Thurman, EC et al. (1998) Regulation of in vitro and in vivo T cell activation by CD43. Int. Immunol. 10 691-701 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Manjunath, N et al. (1995) Negative regulation of T-cell adhesion and activation by CD43. Nature 377 535-8 PubMed GONUTS page
  9. 9.0 9.1 Fratazzi, C et al. (2000) A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J. Exp. Med. 192 183-92 PubMed GONUTS page
  10. 10.0 10.1 Tong, J et al. (2004) CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanism. J. Exp. Med. 199 1277-83 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Sperling, AI et al. (1995) CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182 139-46 PubMed GONUTS page
  12. 12.0 12.1 12.2 Bagriacik, EU et al. (2001) CD43 potentiates CD3-induced proliferation of murine intestinal intraepithelial lymphocytes. Immunol. Cell Biol. 79 303-7 PubMed GONUTS page
  13. Chappel, MS et al. (1996) Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J. Exp. Med. 184 1639-49 PubMed GONUTS page
  14. Wenger, RH et al. (1995) B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24). Transgenic Res. 4 173-83 PubMed GONUTS page
  15. 15.0 15.1 Shiota, J et al. (1994) A unique murine CD43 epitope Lp-3: distinct distribution from another CD43 epitope S7. Cell. Immunol. 155 402-13 PubMed GONUTS page
  16. Cheng, AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378 303-6 PubMed GONUTS page
  17. Cheung, H et al. (2005) Accessory protein-like is essential for IL-18-mediated signaling. J. Immunol. 174 5351-7 PubMed GONUTS page
  18. Garcia, GG & Miller, RA (2003) Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase. Eur. J. Immunol. 33 3464-72 PubMed GONUTS page
  19. 19.0 19.1 19.2 Allenspach, EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15 739-50 PubMed GONUTS page
  20. Tamura, K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102 221-31 PubMed GONUTS page
  21. Fuzii, HT & Travassos, LR (2002) Transient resistance to B16F10 melanoma growth and metastasis in CD43-/- mice. Melanoma Res. 12 9-16 PubMed GONUTS page
  22. 22.0 22.1 22.2 Savage, ND et al. (2002) Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. J. Immunol. 168 3740-6 PubMed GONUTS page
  23. Tsuruyama, T et al. (2010) Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas. J. Leukoc. Biol. 88 107-16 PubMed GONUTS page
  24. Todeschini, AR et al. (2002) Costimulation of host T lymphocytes by a trypanosomal trans-sialidase: involvement of CD43 signaling. J. Immunol. 168 5192-8 PubMed GONUTS page