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PMID:11994475
| Citation |
Todeschini, AR, Nunes, MP, Pires, RS, Lopes, MF, Previato, JO, Mendonça-Previato, L and DosReis, GA (2002) Costimulation of host T lymphocytes by a trypanosomal trans-sialidase: involvement of CD43 signaling. J. Immunol. 168:5192-8 |
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| Abstract |
Trans-sialidase is a membrane-bound and shed sialidase from Trypanosoma cruzi, the protozoan parasite responsible for Chagas disease. We investigated the role of soluble trans-sialidase on host CD4+ T cell activation. Trans-sialidase activated naive CD4+ T cells in vivo. Both enzymatically active and inactive recombinant trans-sialidases costimulated CD4+ T cell activation in vitro. Costimulation resulted in increased mitogen-activated protein kinase activation, proliferation, and cytokine synthesis. Furthermore, active and inactive trans-sialidases blocked activation-induced cell death in CD4+ T cells from T. cruzi-infected mice. By flow cytometry, inactive trans-sialidase bound the highly sialylated surface Ag CD43 on host CD4+ T cells. Both costimulatory and antiapoptotic effects of trans-sialidases required CD43 signaling. These results suggest that trans-sialidase family proteins are involved in exacerbated host T lymphocyte responses observed in T. cruzi infection. |
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| Keywords |
Animals; Antigens, CD; Antigens, CD43; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; CD4-Positive T-Lymphocytes/parasitology; Cells, Cultured; Enzyme Activation/immunology; Glycoproteins; Injections, Subcutaneous; Interphase/immunology; Lymphocyte Activation/immunology; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neuraminidase/administration & dosage; Neuraminidase/antagonists & inhibitors; Neuraminidase/metabolism; Neuraminidase/physiology; Sialoglycoproteins/deficiency; Sialoglycoproteins/genetics; Sialoglycoproteins/metabolism; Sialoglycoproteins/physiology; Trypanosoma cruzi/enzymology; Trypanosoma cruzi/immunology |
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Significance
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