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PMID:24250818
| Citation |
Cannon, JL, Asperti-Boursin, F, Letendre, KA, Brown, IK, Korzekwa, KE, Blaine, KM, Oruganti, SR, Sperling, AI and Moses, ME (2013) PKCθ regulates T cell motility via ezrin-radixin-moesin localization to the uropod. PLoS ONE 8:e78940 |
|---|---|
| Abstract |
Cell motility is a fundamental process crucial for function in many cell types, including T cells. T cell motility is critical for T cell-mediated immune responses, including initiation, activation, and effector function. While many extracellular receptors and cytoskeletal regulators have been shown to control T cell migration, relatively few signaling mediators have been identified that can modulate T cell motility. In this study, we find a previously unknown role for PKCθ in regulating T cell migration to lymph nodes. PKCθ localizes to the migrating T cell uropod and regulates localization of the MTOC, CD43 and ERM proteins to the uropod. Furthermore, PKCθ-deficient T cells are less responsive to chemokine induced migration and are defective in migration to lymph nodes. Our results reveal a novel role for PKCθ in regulating T cell migration and demonstrate that PKCθ signals downstream of CCR7 to regulate protein localization and uropod formation. |
| Links |
PubMed PMC3826749 Online version:10.1371/journal.pone.0078940 |
| Keywords |
Antigens, CD43/metabolism; Cell Movement/genetics; Cytoskeletal Proteins/metabolism; DNA-Binding Proteins/metabolism; Humans; Immunity, Cellular/genetics; Isoenzymes/genetics; Isoenzymes/metabolism; Lymph Nodes/metabolism; Lymph Nodes/pathology; Membrane Proteins/metabolism; Microfilament Proteins/metabolism; Microtubule-Organizing Center/metabolism; Protein Kinase C/genetics; Protein Kinase C/metabolism; Receptors, CCR7/metabolism; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Transcription Factors/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001931: uropod |
ECO:0000314: |
C |
Organism: Homo Sapiens Protein: Leukosialin Figure 4 B) PKCθ regulates MTOC and CD43 localization to uropods |
complete | ||||
Notes
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