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PMID:8920854
| Citation |
Chappel, MS, Hough, MR, Mittel, A, Takei, F, Kay, R and Humphries, RK (1996) Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J. Exp. Med. 184:1639-49 |
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| Abstract |
The murine heat-stable antigen (HSA) is a glycosyl-phosphatidylinositol-linked cell surface protein which has been implicated in cellular adhesion processes, the co-stimulation of CD4+ T cells, and B cell memory. We have recently demonstrated a significant reduction in pro-B and pre-B lymphocytes in transgenic mice that overexpress HSA. We now report that cross-linking HSA with the M1/69 monoclonal antibody induces the apoptosis of cultured B cell precursors in a stomal cell and cytokine-independent manner and that sensitivity to HSA-mediated cell death increases with developmental maturity. The cross-linking of HSA does not induce apoptosis in mature splenic B cells, but instead inhibits their ability to proliferate in response to anti-CD40 + IL-4. Taken together, these data implicate HSA as a potent negative regulator of B cell development and activation. |
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| Keywords |
Animals; Antigens, CD; Antigens, CD24; Antigens, CD40/immunology; Antigens, Differentiation/immunology; B-Lymphocytes/immunology; Cell Differentiation; Cells, Cultured; Clone Cells; Cross-Linking Reagents; Hematopoietic Stem Cells/immunology; Interleukin-7/pharmacology; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Spleen/cytology; Spleen/immunology; Stromal Cells/immunology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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