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HUMAN:CCAR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CCAR1 (synonyms: CARP1, DIS)
Protein Name(s) Cell division cycle and apoptosis regulator protein 1

Cell cycle and apoptosis regulatory protein 1 CARP-1 Death inducer with SAP domain

External Links
UniProt Q8IX12
EMBL AY249140
AF465616
AK000741
AK001452
AK001701
AK023438
AK298004
AK299307
AK292649
AL513534
AL391539
AL391539
AL513534
CH471083
BC015475
BC026036
BC089420
BC130626
BC132725
BC108682
CCDS CCDS60547.1
CCDS7282.1
RefSeq NP_001269888.1
NP_001269889.1
NP_060707.2
UniGene Hs.49853
ProteinModelPortal Q8IX12
BioGrid 120867
DIP DIP-27607N
IntAct Q8IX12
MINT MINT-1139760
PhosphoSite Q8IX12
DMDM 94707499
MaxQB Q8IX12
PaxDb Q8IX12
PeptideAtlas Q8IX12
PRIDE Q8IX12
Ensembl ENST00000265872
ENST00000539539
ENST00000543719
GeneID 55749
KEGG hsa:55749
UCSC uc001jom.1
uc010qiz.1
CTD 55749
GeneCards GC10P070480
HGNC HGNC:24236
HPA HPA007856
HPA048513
MIM 612569
neXtProt NX_Q8IX12
PharmGKB PA134920227
eggNOG NOG313311
GeneTree ENSGT00530000063672
HOVERGEN HBG079908
InParanoid Q8IX12
OMA PNWAAKN
OrthoDB EOG7CK365
PhylomeDB Q8IX12
TreeFam TF316387
Reactome REACT_467
ChiTaRS CCAR1
GeneWiki CCAR1
GenomeRNAi 55749
NextBio 60733
PRO PR:Q8IX12
Proteomes UP000005640
Bgee Q8IX12
CleanEx HS_CCAR1
ExpressionAtlas Q8IX12
Genevestigator Q8IX12
GO GO:0005654
GO:0048471
GO:0030374
GO:0044822
GO:0006915
GO:0007049
GO:0010467
GO:0000398
GO:0006355
GO:0008380
GO:0006351
Gene3D 1.10.720.30
2.40.50.140
InterPro IPR025224
IPR025954
IPR012340
IPR025223
IPR003034
PANTHER PTHR14304
Pfam PF14443
PF14444
PF02037
SMART SM00513
SUPFAM SSF50249
PROSITE PS50800

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006915

apoptotic process

PMID:12816952[1]

ECO:0000270

P

Fig. 2,3 & 4

complete
CACAO 3729

enables

GO:0003713

transcription coactivator activity

PMID:23887938[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:24245781[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:24245781[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:23887938[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:23887938[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

PMID:23887938[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030374

nuclear receptor transcription coactivator activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000370966
UniProtKB:Q8IX12

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000370966
TAIR:locus:2056881

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000370966
TAIR:locus:2056881
UniProtKB:Q8N163

C

Seeded From UniProt

complete

enables

GO:0030374

nuclear receptor transcription coactivator activity

PMID:18722177[7]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P03372

F

Seeded From UniProt

complete

involved_in

GO:1903507

negative regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003714

P

Seeded From UniProt

complete

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003713

P

Seeded From UniProt

complete

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003713

P

Seeded From UniProt

complete

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003713

P

Seeded From UniProt

complete

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030374

P

Seeded From UniProt

complete

involved_in

GO:1903508

positive regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030374

P

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CH18
ensembl:ENSMUSP00000020268

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR025224

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-72160
Reactome:R-HSA-72143
Reactome:R-HSA-72139
Reactome:R-HSA-72130
Reactome:R-HSA-72127
Reactome:R-HSA-72124
Reactome:R-HSA-72107
Reactome:R-HSA-156661

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

Reactome:R-HSA-72163

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Rishi, AK et al. (2003) Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437. J. Biol. Chem. 278 33422-35 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Seo, WY et al. (2013) CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2. Nucleic Acids Res. 41 8526-36 PubMed GONUTS page
  3. ↑ 3.0 3.1 Mizuta, S et al. (2014) CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. Genes Cells 19 28-51 PubMed GONUTS page
  4. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  5. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Kim, JH et al. (2008) CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol. Cell 31 510-9 PubMed GONUTS page
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