MOUSE:SIX3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Six3
Protein Name(s)	Homeobox protein SIX3 Sine oculis homeobox homolog 3
External Links
UniProt	Q62233
EMBL	X90871 D83144 D83145 BC098096
CCDS	CCDS50203.1
PIR	S74255
RefSeq	NP_035511.2
UniGene	Mm.370208 Mm.391586
ProteinModelPortal	Q62233
SMR	Q62233
BioGrid	203261
DIP	DIP-46499N
IntAct	Q62233
STRING	10090.ENSMUSP00000039867
PhosphoSite	Q62233
MaxQB	Q62233
PRIDE	Q62233
Ensembl	ENSMUST00000175898 ENSMUST00000176081
GeneID	20473
KEGG	mmu:20473
UCSC	uc008dtz.2
CTD	6496
MGI	MGI:102764
eggNOG	NOG244436
GeneTree	ENSGT00540000070251
HOVERGEN	HBG003609
InParanoid	Q62233
TreeFam	TF315545
NextBio	298587
PRO	PR:Q62233
Proteomes	UP000000589
Bgee	Q62233
ExpressionAtlas	Q62233
Genevestigator	Q62233
GO	GO:0005634 GO:0003677 GO:0042826 GO:0000980 GO:0003705 GO:0001205 GO:0043565 GO:0003700 GO:0003713 GO:0001222 GO:1902742 GO:0007420 GO:0043010 GO:0021846 GO:0048512 GO:0021536 GO:0002070 GO:0001654 GO:0021797 GO:0021798 GO:0002088 GO:1990086 GO:0070306 GO:0060235 GO:0045665 GO:0045892 GO:0030178 GO:0014016 GO:0097402 GO:0003404 GO:0021983 GO:0045944 GO:0006606 GO:0000060 GO:0009946 GO:1901987 GO:0042127 GO:2000177 GO:0061074 GO:1902692 GO:0021537 GO:0021978 GO:0006366
Gene3D	1.10.10.60
InterPro	IPR001356 IPR009057
Pfam	PF00046
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002088	lens development in camera-type eye	PMID:17066077^[1]	ECO:0000315			P		Fig 1H,k,l	complete
	GO:0010628	positive regulation of gene expression	PMID:17066077^[1]	ECO:0000315			P		Fig 3c'+D'	complete
	GO:0035326	enhancer binding	PMID:17066077^[1]	ECO:0000314			F		Fig 7A	complete
	GO:0043193	positive regulation of gene-specific transcription	PMID:17066077^[1]	ECO:0000314			P		Fig 7c	complete
	GO:0016563	transcription activator activity	PMID:17066077^[1]	ECO:0000314			F		Fig 7c	complete
	GO:0046619	optic placode formation involved in camera-type eye	PMID:17066077^[1]	ECO:0000315			P		Fig 4A',b'+j	complete
involved_in	GO:0021798	forebrain dorsal/ventral pattern formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95343	P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	PMID:11139622^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11139622^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	PMID:17576749^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000177	regulation of neural precursor cell proliferation	PMID:17576749^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:17666527^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P70288	F		Seeded From UniProt	complete
enables	GO:0001222	transcription corepressor binding	PMID:17666527^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8K4B0	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:17666527^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070306	lens fiber cell differentiation	PMID:12072567^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990086	lens fiber cell apoptotic process	PMID:12072567^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061074	regulation of neural retina development	PMID:20890044^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:18775421^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	PMID:18775421^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014016	neuroblast differentiation	PMID:22071110^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901987	regulation of cell cycle phase transition	PMID:17576749^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17666527^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902692	regulation of neuroblast proliferation	PMID:22071110^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097402	neuroblast migration	PMID:22071110^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002070	epithelial cell maturation	PMID:22071110^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021978	telencephalon regionalization	PMID:18694563^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902742	apoptotic process involved in development	PMID:18694563^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021846	cell proliferation in forebrain	PMID:18694563^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	PMID:18694563^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009946	proximal/distal axis specification	PMID:12163408^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003404	optic vesicle morphogenesis	PMID:11458394^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17066077^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:18508)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:17066077^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:17066077^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:106034 PANTHER:PTN000044272	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102764 MGI:MGI:106034 MGI:MGI:106220 PANTHER:PTN000044272 RGD:620909 UniProtKB:O95343	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102764 PANTHER:PTN002571848 ZFIN:ZDB-GENE-990415-127 ZFIN:ZDB-GENE-990415-128	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 PANTHER:PTN000044272	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003460 MGI:MGI:102764 MGI:MGI:102778 MGI:MGI:102780 MGI:MGI:106034 MGI:MGI:106220 MGI:MGI:1341840 PANTHER:PTN000044272 RGD:620906 UniProtKB:Q15475 WB:WBGene00000453 WB:WBGene00000455 WB:WBGene00006775	C		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102764 PANTHER:PTN002470536 UniProtKB:O95343 ZFIN:ZDB-GENE-050522-308 ZFIN:ZDB-GENE-990415-128 ZFIN:ZDB-GENE-990825-28	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000044272 ZFIN:ZDB-GENE-040718-155	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000044272 dictyBase:DDB_G0272967	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060235	lens induction in camera-type eye	PMID:17066077^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3693322	P	has_participant:(EMAPA:16799)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048512	circadian behavior	PMID:21525287^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3693321	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17066077^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97490)\|has_regulation_target:(MGI:MGI:98364)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12050133^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95343	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620909	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8814301^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:88105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:12072567^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97490	P	results_in_development_of:(EMAPA:17163)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:12569128^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021798	forebrain dorsal/ventral pattern formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95343	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021797	forebrain anterior/posterior pattern specification	PMID:18094027^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98953	P	has_participant:(EMAPA:16641)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021797	forebrain anterior/posterior pattern specification	PMID:18094027^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450901	P	has_participant:(EMAPA:16512)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:18094027^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450901	P	results_in_development_of:(EMAPA:16652)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021536	diencephalon development	PMID:18094027^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98953	P	results_in_development_of:(EMAPA:16641)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:12569128^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	PMID:16024294^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(MGI:MGI:109344)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8814301^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16024294^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16672) part_of:(CL:0000114)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12050133^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620909	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12050133^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001654	eye development	PMID:12050133^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001654	eye development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95343	P		Seeded From UniProt	complete
enables	GO:0001222	transcription corepressor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95343	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:17066077^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:97490)\|has_regulation_target:(MGI:MGI:98364)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:12569128^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95343 ensembl:ENSP00000260653	P		Seeded From UniProt	complete
involved_in	GO:0021798	forebrain dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95343 ensembl:ENSP00000260653	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95343 ensembl:ENSP00000260653	P		Seeded From UniProt	complete
enables	GO:0001222	transcription corepressor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95343 ensembl:ENSP00000260653	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K2C0 ensembl:ENSRNOP00000072181	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K2C0 ensembl:ENSRNOP00000072181	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032949	F		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032949	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032949	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032949	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Liu, W et al. (2006) Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J. 25 5383-95 PubMed GONUTS page
↑ ^2.0 ^2.1 Lengler, J et al. (2001) Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Nucleic Acids Res. 29 515-26 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Appolloni, I et al. (2008) Six3 controls the neural progenitor status in the murine CNS. Cereb. Cortex 18 553-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Manavathi, B et al. (2007) Repression of Six3 by a corepressor regulates rhodopsin expression. Proc. Natl. Acad. Sci. U.S.A. 104 13128-33 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Goudreau, G et al. (2002) Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc. Natl. Acad. Sci. U.S.A. 99 8719-24 PubMed GONUTS page
↑ Liu, W et al. (2010) Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J. Clin. Invest. 120 3568-77 PubMed GONUTS page
↑ ^7.0 ^7.1 Gaston-Massuet, C et al. (2008) Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev. Biol. 324 322-33 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Lavado, A & Oliver, G (2011) Six3 is required for ependymal cell maturation. Development 138 5291-300 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Geng, X et al. (2008) Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev. Cell 15 236-47 PubMed GONUTS page
↑ Carl, M et al. (2002) Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye. Development 129 4057-63 PubMed GONUTS page
↑ Lagutin, O et al. (2001) Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. Dev. Dyn. 221 342-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ VanDunk, C et al. (2011) Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J. Neurosci. 31 6457-67 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Zhu, CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development 129 2835-49 PubMed GONUTS page
↑ ^15.0 ^15.1 Kawakami, K et al. (1996) Identification and expression of six family genes in mouse retina. FEBS Lett. 393 259-63 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Lagutin, OV et al. (2003) Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev. 17 368-79 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Lavado, A et al. (2008) Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development 135 441-50 PubMed GONUTS page
↑ ^18.0 ^18.1 Purcell, P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr. Patterns 6 110-8 PubMed GONUTS page

[PMID:17066077-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Liu, W et al. (2006) Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J. 25 5383-95 PubMed GONUTS page

[PMID:11139622-2] 2.0 ^2.1 Lengler, J et al. (2001) Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Nucleic Acids Res. 29 515-26 PubMed GONUTS page

[PMID:17576749-3] 3.0 ^3.1 ^3.2 Appolloni, I et al. (2008) Six3 controls the neural progenitor status in the murine CNS. Cereb. Cortex 18 553-62 PubMed GONUTS page

[PMID:17666527-4] 4.0 ^4.1 ^4.2 ^4.3 Manavathi, B et al. (2007) Repression of Six3 by a corepressor regulates rhodopsin expression. Proc. Natl. Acad. Sci. U.S.A. 104 13128-33 PubMed GONUTS page

[PMID:12072567-5] 5.0 ^5.1 ^5.2 Goudreau, G et al. (2002) Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc. Natl. Acad. Sci. U.S.A. 99 8719-24 PubMed GONUTS page

[PMID:20890044-6] Liu, W et al. (2010) Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J. Clin. Invest. 120 3568-77 PubMed GONUTS page

[PMID:18775421-7] 7.0 ^7.1 Gaston-Massuet, C et al. (2008) Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev. Biol. 324 322-33 PubMed GONUTS page

[PMID:22071110-8] 8.0 ^8.1 ^8.2 ^8.3 Lavado, A & Oliver, G (2011) Six3 is required for ependymal cell maturation. Development 138 5291-300 PubMed GONUTS page

[PMID:18694563-9] 9.0 ^9.1 ^9.2 ^9.3 Geng, X et al. (2008) Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev. Cell 15 236-47 PubMed GONUTS page

[PMID:12163408-10] Carl, M et al. (2002) Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye. Development 129 4057-63 PubMed GONUTS page

[PMID:11458394-11] Lagutin, O et al. (2001) Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. Dev. Dyn. 221 342-9 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21525287-13] VanDunk, C et al. (2011) Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J. Neurosci. 31 6457-67 PubMed GONUTS page

[PMID:12050133-14] 14.0 ^14.1 ^14.2 ^14.3 Zhu, CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development 129 2835-49 PubMed GONUTS page

[PMID:8814301-15] 15.0 ^15.1 Kawakami, K et al. (1996) Identification and expression of six family genes in mouse retina. FEBS Lett. 393 259-63 PubMed GONUTS page

[PMID:12569128-16] 16.0 ^16.1 ^16.2 Lagutin, OV et al. (2003) Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev. 17 368-79 PubMed GONUTS page

[PMID:18094027-17] 17.0 ^17.1 ^17.2 ^17.3 Lavado, A et al. (2008) Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development 135 441-50 PubMed GONUTS page

[PMID:16024294-18] 18.0 ^18.1 Purcell, P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr. Patterns 6 110-8 PubMed GONUTS page

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MOUSE:SIX3

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