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PMID:12163408

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Citation

Carl, M, Loosli, F and Wittbrodt, J (2002) Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye. Development 129:4057-63

Abstract

The establishment of retinal identity and the subsequent patterning of the optic vesicle are the key steps in early vertebrate eye development. To date little is known about the nature and interaction of the genes controlling these steps. So far few genes have been identified that, when over-expressed, can initiate ectopic eye formation. Of note is Six3, which is expressed exclusively in the anterior neural plate. However, 'loss of function' analysis has not been reported. Using medaka fish, we show that vertebrate Six3 is necessary for patterning of the anterior neuroectoderm including the retina anlage. Inactivation of Six3 function by morpholino knock-down results in the lack of forebrain and eyes. Corroborated by gain-of-function experiments, graded interference reveals an additional role of Six3 in the proximodistal patterning of the optic vesicle. During both processes of vertebrate eye formation, Six3 cooperates with Pax6.

Links

PubMed

Keywords

Animals; Body Patterning; Ectoderm/physiology; Epistasis, Genetic; Eye/embryology; Eye Proteins; Fish Proteins; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Homeodomain Proteins/physiology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Neuropeptides/metabolism; Oryzias; Paired Box Transcription Factors; Prosencephalon/embryology; Repressor Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SIX3

involved_in

GO:0009946: proximal/distal axis specification

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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