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MOUSE:KMT2D

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Kmt2d (synonyms: Mll2, Mll4)
Protein Name(s) Histone-lysine N-methyltransferase 2D

Lysine N-methyltransferase 2D ALL1-related protein Myeloid/lymphoid or mixed-lineage leukemia protein 2

External Links
UniProt Q6PDK2
EMBL AC161165
BC058659
CCDS CCDS49725.2
UniGene Mm.264889
ProteinModelPortal Q6PDK2
SMR Q6PDK2
IntAct Q6PDK2
STRING 10090.ENSMUSP00000135941
iPTMnet Q6PDK2
PhosphoSitePlus Q6PDK2
EPD Q6PDK2
MaxQB Q6PDK2
PaxDb Q6PDK2
PeptideAtlas Q6PDK2
PRIDE Q6PDK2
Ensembl ENSMUST00000178486
MGI MGI:2682319
eggNOG KOG4443
COG2940
GeneTree ENSGT00760000119228
HOGENOM HOG000168503
InParanoid Q6PDK2
OMA QSTNYAV
OrthoDB EOG091G000T
PhylomeDB Q6PDK2
Reactome R-MMU-201722
R-MMU-3214841
R-MMU-3769402
R-MMU-8936459
ChiTaRS Kmt2d
PRO PR:Q6PDK2
Proteomes UP000000589
Bgee ENSMUSG00000048154
ExpressionAtlas Q6PDK2
Genevisible Q6PDK2
GO GO:0035097
GO:0044666
GO:0005654
GO:0042800
GO:0046872
GO:0044212
GO:0006342
GO:0051568
GO:0001701
GO:0001555
GO:0048477
GO:0008284
GO:0033148
GO:0045944
GO:0010468
GO:0043627
GO:0006351
Gene3D 1.10.30.10
3.30.40.10
InterPro IPR034732
IPR003889
IPR003888
IPR009071
IPR036910
IPR037890
IPR003616
IPR001214
IPR011011
IPR001965
IPR019787
IPR001841
IPR013083
PANTHER PTHR22884:SF380
Pfam PF05965
PF05964
PF00628
PF00856
SMART SM00542
SM00541
SM00398
SM00249
SM00508
SM00184
SM00317
SUPFAM SSF47095
SSF57903
PROSITE PS51805
PS51543
PS51542
PS50868
PS50280
PS01359
PS50016
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051568

histone H3-K4 methylation

PMID:20808952[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048477

oogenesis

PMID:20808952[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006342

chromatin silencing

PMID:20808952[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001555

oocyte growth

PMID:20808952[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263667
PANTHER:PTN002505160
UniProtKB:O14686

P

Seeded From UniProt

complete

part_of

GO:0044666

MLL3/4 complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023518
FB:FBgn0263667
PANTHER:PTN002505160
UniProtKB:O14686
UniProtKB:Q8NEZ4
WB:WBGene00011729

C

Seeded From UniProt

complete

enables

GO:0042800

histone methyltransferase activity (H3-K4 specific)

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023518
PANTHER:PTN002505160
UniProtKB:Q8NEZ4
WB:WBGene00011729

F

Seeded From UniProt

complete

enables

GO:0042393

histone binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263667
PANTHER:PTN002505160

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023518
PANTHER:PTN002505160

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14686

P

Seeded From UniProt

complete

part_of

GO:0044666

MLL3/4 complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14686

C

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14686

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043627

response to estrogen

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14686

P

Seeded From UniProt

complete

part_of

GO:0035097

histone methyltransferase complex

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14686

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14686

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:17021013[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14686

P

Seeded From UniProt

complete

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:26691508[4]

ECO:0000314

F

Protein Name: c-Myc Uniprot ID: P01108 GO ID: G Notes: Fig. 1C and D shows that Mouse cells treated with c-Myc (a transcription factor identified in Uniprot as Myc) exhibit increased mRNA levels of the genes Wdr5 and Dpy30 relative to the control. Fig 1H shows that c-Myc binds the promoter.

complete
CACAO 13349

acts_upstream_of_or_within

GO:0001701

in utero embryonic development

PMID:16540515[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3623309

P

has_participant:(EMAPA:16039)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003888
InterPro:IPR003889

C

Seeded From UniProt

complete

part_of

GO:0035097

histone methyltransferase complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037890

C

Seeded From UniProt

complete

enables

GO:0042800

histone methyltransferase activity (H3-K4 specific)

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037890

F

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.43

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-MMU-6810170
Reactome:R-MMU-6810169
Reactome:R-MMU-6810150
Reactome:R-MMU-5693628
Reactome:R-MMU-5621012
Reactome:R-MMU-5621004
Reactome:R-MMU-5619441
Reactome:R-MMU-5619440
Reactome:R-MMU-5619437
Reactome:R-MMU-5619436
Reactome:R-MMU-5619434
Reactome:R-MMU-5619430
Reactome:R-MMU-5619424
Reactome:R-MMU-5619411
Reactome:R-MMU-5617990
Reactome:R-MMU-5617960

ECO:0000304

author statement supported by traceable reference used in manual assertion
















C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Andreu-Vieyra, CV et al. (2010) MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol. 8 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Lee, S et al. (2006) Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc. Natl. Acad. Sci. U.S.A. 103 15392-7 PubMed GONUTS page
  4. ↑ Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page
  5. ↑ Glaser, S et al. (2006) Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development 133 1423-32 PubMed GONUTS page
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