HUMAN:PO3F2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	POU3F2 (synonyms: BRN2, OCT7, OTF7)
Protein Name(s)	POU domain, class 3, transcription factor 2 Brain-specific homeobox/POU domain protein 2 Brain-2 Brn-2 Nervous system-specific octamer-binding transcription factor N-Oct-3 Octamer-binding protein 7 Oct-7 Octamer-binding transcription factor 7 OTF-7
External Links
UniProt	P20265
EMBL	Z11933 L37868 AL022395 BC051699
CCDS	CCDS5040.1
PIR	S29334
RefSeq	NP_005595.2
UniGene	Hs.182505
ProteinModelPortal	P20265
SMR	P20265
BioGrid	111450
IntAct	P20265
MINT	MINT-2801637
STRING	9606.ENSP00000329170
BindingDB	P20265
ChEMBL	CHEMBL4189
PhosphoSite	P20265
DMDM	78100757
MaxQB	P20265
PaxDb	P20265
PRIDE	P20265
Ensembl	ENST00000328345
GeneID	5454
KEGG	hsa:5454
UCSC	uc003ppe.3
CTD	5454
GeneCards	GC06P099295
HGNC	HGNC:9215
MIM	600494
neXtProt	NX_P20265
PharmGKB	PA33539
eggNOG	NOG261729
GeneTree	ENSGT00760000118935
HOGENOM	HOG000116303
HOVERGEN	HBG053120
InParanoid	P20265
KO	K09365
OMA	MHNSSNN
OrthoDB	EOG7DJSMG
PhylomeDB	P20265
TreeFam	TF316413
SignaLink	P20265
ChiTaRS	POU3F2
GeneWiki	POU3F2
GenomeRNAi	5454
NextBio	21109
PRO	PR:P20265
Proteomes	UP000005640
Bgee	P20265
CleanEx	HS_POU3F2
Genevestigator	P20265
GO	GO:0005634 GO:0005667 GO:0042802 GO:0001105 GO:0043565 GO:0003700 GO:0014002 GO:0071310 GO:0021799 GO:0008544 GO:0021869 GO:0021979 GO:0022011 GO:0021985 GO:0030182 GO:0008284 GO:0040018 GO:0050770
Gene3D	1.10.10.60 1.10.260.40
InterPro	IPR017970 IPR001356 IPR009057 IPR010982 IPR013847 IPR000327 IPR016362
Pfam	PF00046 PF00157
PIRSF	PIRSF002629
PRINTS	PR00028
SMART	SM00389 SM00352
SUPFAM	SSF46689 SSF47413
PROSITE	PS00027 PS50071 PS00035 PS00465 PS51179

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000327 InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR010982 InterPro:IPR013847 InterPro:IPR016362	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P20263	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31360	F	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31360	P	Seeded From UniProt	complete
involved_in	GO:0048665	neuron fate specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31360	P	Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31360	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31360	P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31360	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31360	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15024079^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:11029584^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20265	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0050770	regulation of axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0048665	neuron fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	F	Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0022011	myelination in peripheral nervous system	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0021985	neurohypophysis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0021979	hypothalamus cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0021869	forebrain ventricular zone progenitor cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0021799	cerebral cortex radially oriented cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0014044	Schwann cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0014002	astrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	P	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	F	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31360 ensembl:ENSMUSP00000136147	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR010982 InterPro:IPR013847	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327 InterPro:IPR016362	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016362	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327 InterPro:IPR017970	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016362	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016362	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9482665^[4] PMID:7601453^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Goodall, J et al. (2004) Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol. Cell. Biol. 24 2915-22 PubMed GONUTS page
↑ Smit, DJ et al. (2000) Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors. Eur. J. Biochem. 267 6413-22 PubMed GONUTS page
↑ Petersenn, S et al. (1998) Structure and regulation of the human growth hormone-releasing hormone receptor gene. Mol. Endocrinol. 12 233-47 PubMed GONUTS page
↑ Atanasoski, S et al. (1995) Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. Genomics 26 272-80 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:15024079-2] Goodall, J et al. (2004) Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol. Cell. Biol. 24 2915-22 PubMed GONUTS page

[PMID:11029584-3] Smit, DJ et al. (2000) Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors. Eur. J. Biochem. 267 6413-22 PubMed GONUTS page

[PMID:9482665-4] Petersenn, S et al. (1998) Structure and regulation of the human growth hormone-releasing hormone receptor gene. Mol. Endocrinol. 12 233-47 PubMed GONUTS page

[PMID:7601453-5] Atanasoski, S et al. (1995) Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. Genomics 26 272-80 PubMed GONUTS page

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HUMAN:PO3F2

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