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HUMAN:DYR1B

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DYRK1B (synonyms: MIRK)
Protein Name(s) Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Minibrain-related kinase Mirk protein kinase

External Links
UniProt Q9Y463
EMBL Y17999
Y17999
Y17999
AF205861
AC005393
BC018751
BC025291
CCDS CCDS12543.1
CCDS12544.1
CCDS46075.1
PIR JG0195
RefSeq NP_004705.1
NP_006474.1
NP_006475.1
XP_005259455.1
UniGene Hs.130988
ProteinModelPortal Q9Y463
SMR Q9Y463
BioGrid 114596
IntAct Q9Y463
MINT MINT-2790122
STRING 9606.ENSP00000312789
BindingDB Q9Y463
ChEMBL CHEMBL5543
GuidetoPHARMACOLOGY 2010
iPTMnet Q9Y463
PhosphoSitePlus Q9Y463
BioMuta DYRK1B
DMDM 9296963
EPD Q9Y463
PaxDb Q9Y463
PeptideAtlas Q9Y463
PRIDE Q9Y463
DNASU 9149
Ensembl ENST00000323039
ENST00000348817
ENST00000430012
ENST00000593685
ENST00000597639
ENST00000625388
ENST00000625438
ENST00000625757
ENST00000627034
ENST00000631090
GeneID 9149
KEGG hsa:9149
UCSC uc002omi.4
CTD 9149
DisGeNET 9149
GeneCards DYRK1B
HGNC HGNC:3092
HPA HPA028522
HPA028786
MalaCards DYRK1B
MIM 604556
615812
neXtProt NX_Q9Y463
OpenTargets ENSG00000105204
PharmGKB PA27549
eggNOG KOG0667
ENOG410XPET
GeneTree ENSGT00760000119032
HOGENOM HOG000220863
HOVERGEN HBG051425
InParanoid Q9Y463
KO K08825
OMA HKPAATQ
OrthoDB EOG091G03J7
PhylomeDB Q9Y463
TreeFam TF314624
BioCyc MetaCyc:HS02690-MONOMER
BRENDA 2.7.12.1
SignaLink Q9Y463
SIGNOR Q9Y463
ChiTaRS DYRK1B
GeneWiki DYRK1B
GenomeRNAi 9149
PRO PR:Q9Y463
Proteomes UP000005640
Bgee ENSG00000105204
CleanEx HS_DYRK1B
ExpressionAtlas Q9Y463
Genevisible Q9Y463
GO GO:0005634
GO:0005524
GO:0004672
GO:0004674
GO:0004712
GO:0004713
GO:0003713
GO:0060612
GO:0007520
GO:0045893
GO:0006468
InterPro IPR033565
IPR011009
IPR000719
IPR017441
IPR008271
PANTHER PTHR24058:SF90
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0060612

adipose tissue development

PMID:24827035[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:11980910[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:11980910[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:11980910[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:11980910[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0007520

myoblast fusion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z188
ensembl:ENSMUSP00000133431

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033565

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033565

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0004712

protein serine/threonine/tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.12.1

F

Seeded From UniProt

complete

GO:0046809

replication compartment

PMID:28400201[3]

ECO:0000314

C

HUMAN DYR1B (DYRK1B) // “ DYRK1B was exclusively present in the nucleus and strongly localized within nuclear replication compartments of infected cells as demonstrated by colocalisation with viral IE/E staining (Fig. 1A).”

complete
CACAO 12873

involved_in

GO:0006468

protein phosphorylation

PMID:9918863[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:28400201[3]

ECO:0000314

C

HUMAN DYR1B (DYRK1B) // “ DYRK1B was exclusively present in the nucleus and strongly localized within nuclear replication compartments of infected cells as demonstrated by colocalisation with viral IE/E staining (Fig. 1A).”

complete
CACAO 12874

part_of

GO:0005634

nucleus

PMID:9918863[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:9918863[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Keramati, AR et al. (2014) A form of the metabolic syndrome associated with mutations in DYRK1B. N. Engl. J. Med. 370 1909-19 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Lim, S et al. (2002) Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. J. Biol. Chem. 277 25040-6 PubMed GONUTS page
  3. ↑ 3.0 3.1 Hutterer, C et al. (2017) Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity. Antiviral Res. PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Leder, S et al. (1999) Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. Biochem. Biophys. Res. Commun. 254 474-9 PubMed GONUTS page
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