MOUSE:FUS

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fus
Protein Name(s)	RNA-binding protein FUS Protein pigpen
External Links
UniProt	P56959
EMBL	AF224264
CCDS	CCDS21886.1
RefSeq	NP_631888.1
UniGene	Mm.277680
ProteinModelPortal	P56959
SMR	P56959
BioGrid	231475
IntAct	P56959
MINT	MINT-136330
STRING	10090.ENSMUSP00000101858
iPTMnet	P56959
PhosphoSitePlus	P56959
EPD	P56959
PaxDb	P56959
PeptideAtlas	P56959
PRIDE	P56959
Ensembl	ENSMUST00000106251
GeneID	233908
KEGG	mmu:233908
UCSC	uc009jxo.1
CTD	2521
MGI	MGI:1353633
eggNOG	ENOG410IP58 ENOG4111GEG
GeneTree	ENSGT00530000063105
HOGENOM	HOG000038010
HOVERGEN	HBG094940
InParanoid	P56959
KO	K13098
OMA	YGQTQNS
OrthoDB	EOG091G0U8W
PhylomeDB	P56959
TreeFam	TF322599
Reactome	[www.reactome.org/content/detail/R-MMU-72163 R-MMU-72163]
ChiTaRS	Fus
PRO	PR:P56959
Proteomes	UP000000589
Bgee	ENSMUSG00000030795
ExpressionAtlas	P56959
Genevisible	P56959
GO	GO:0005737 GO:0044327 GO:0005654 GO:0005634 GO:0043204 GO:0048471 GO:0005844 GO:0003677 GO:0000166 GO:0003723 GO:0003713 GO:0008270 GO:0071277
Gene3D	3.30.70.330 4.10.1060.10
InterPro	IPR034459 IPR012677 IPR000504 IPR001876
PANTHER	PTHR23238:SF29
Pfam	PF00076 PF00641
SMART	SM00360 SM00547
SUPFAM	SSF54928 SSF90209
PROSITE	PS50102 PS01358 PS50199

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0003723	RNA binding	PMID:28358055^[1]	ECO:0000314			F	Attaches to double stranded and single stranded DNA, and helps maintain DNA fidelity to create mRNA.	complete CACAO 12760
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011571 MGI:MGI:1353633 MGI:MGI:99960 PANTHER:PTN000579998 UniProtKB:P35637 UniProtKB:Q01844 UniProtKB:Q92804	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071277	cellular response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	C	Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	F	Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	F	Seeded From UniProt	complete
part_of	GO:0044327	dendritic spine head	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	C	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	C	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	C	Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	F	Seeded From UniProt	complete
enables	GO:0031489	myosin V binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	F	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	C	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	F	Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12950080^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308864	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12950080^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35637	C	Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003713	P	Seeded From UniProt	complete
involved_in	GO:1905168	positive regulation of double-strand break repair via homologous recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	P	Seeded From UniProt	complete
involved_in	GO:0043484	regulation of RNA splicing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	F	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	C	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35637 ensembl:ENSP00000254108	F	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	C	Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	F	Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	F	Seeded From UniProt	complete
part_of	GO:0044327	dendritic spine head	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	C	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	C	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	C	Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	F	Seeded From UniProt	complete
enables	GO:0031489	myosin V binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	F	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	C	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	F	Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5PQK2 ensembl:ENSRNOP00000033029	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6IBQ5 ensembl:ENSP00000254108	C	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034459 InterPro:IPR034870	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034870	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Errichelli, L et al. (2017) FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Nat Commun 8 14741 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Alappat, SR et al. (2003) Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis. Dev. Dyn. 228 59-71 PubMed GONUTS page

[PMID:28358055-1] Errichelli, L et al. (2017) FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Nat Commun 8 14741 PubMed GONUTS page

[PMID:21873635-2] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12950080-3] 3.0 ^3.1 Alappat, SR et al. (2003) Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis. Dev. Dyn. 228 59-71 PubMed GONUTS page

[1]

[2]

[3]

MOUSE:FUS

Contents

Annotations

Notes

References

c

d

e

g

i

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools