MOUSE:SMCA4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Smarca4 (synonyms: Baf190a, Brg1, Snf2b, Snf2l4)
Protein Name(s)	Transcription activator BRG1 ATP-dependent helicase SMARCA4 BRG1-associated factor 190A BAF190A Protein brahma homolog 1 SNF2-beta SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
External Links
UniProt	Q3TKT4
EMBL	AK147285 AK160825 AK166837 BC079560 CH466522
CCDS	CCDS22909.1 CCDS57662.1
RefSeq	NP_001167549.1 NP_001167550.1 NP_035547.2
UniGene	Mm.286593
ProteinModelPortal	Q3TKT4
SMR	Q3TKT4
BioGrid	203336
DIP	DIP-40650N DIP-59249N
IntAct	Q3TKT4
MINT	MINT-1958721
STRING	10090.ENSMUSP00000096547
PhosphoSite	Q3TKT4
MaxQB	Q3TKT4
PaxDb	Q3TKT4
PRIDE	Q3TKT4
Ensembl	ENSMUST00000034707 ENSMUST00000098948 ENSMUST00000174008
GeneID	20586
KEGG	mmu:20586
UCSC	uc009omd.2 uc009ome.2
CTD	6597
MGI	MGI:88192
eggNOG	COG0553
GeneTree	ENSGT00550000074659
HOGENOM	HOG000172363
HOVERGEN	HBG056636
InParanoid	Q3TKT4
KO	K11647
OrthoDB	EOG771265
PhylomeDB	Q3TKT4
TreeFam	TF300785
Reactome	REACT_216539 REACT_244207
ChiTaRS	Smarca4
NextBio	298883
PRO	PR:Q3TKT4
Proteomes	UP000000589
Bgee	Q3TKT4
ExpressionAtlas	Q3TKT4
Genevestigator	Q3TKT4
GO	GO:0005615 GO:0000792 GO:0016020 GO:0071565 GO:0071564 GO:0005719 GO:0005634 GO:0005726 GO:0016514 GO:0005524 GO:0016887 GO:0003682 GO:0070182 GO:0008094 GO:0004386 GO:0000978 GO:0000980 GO:0000977 GO:0001105 GO:0003714 GO:0008134 GO:0035887 GO:0043044 GO:0001832 GO:0001835 GO:0001568 GO:0000902 GO:0006338 GO:0060318 GO:0010424 GO:0035116 GO:0048562 GO:0048730 GO:0030198 GO:0030900 GO:0007403 GO:0007507 GO:0060347 GO:0030902 GO:0043966 GO:0001701 GO:0030216 GO:0070307 GO:0001889 GO:0006346 GO:0060766 GO:0043066 GO:0030308 GO:0000122 GO:0007399 GO:0003407 GO:0022008 GO:0006334 GO:0006337 GO:0003151 GO:0061626 GO:0043923 GO:0045597 GO:0008284 GO:0043388 GO:0051091 GO:0045944 GO:0030177 GO:0030334 GO:0019827 GO:0001570
Gene3D	1.20.920.10 3.40.50.300
InterPro	IPR030100 IPR006576 IPR001487 IPR018359 IPR014978 IPR013999 IPR014012 IPR014001 IPR001650 IPR027417 IPR029295 IPR000330
PANTHER	PTHR10799:SF76
Pfam	PF07533 PF00439 PF00271 PF07529 PF08880 PF14619 PF00176
PRINTS	PR00503
SMART	SM00592 SM00297 SM00487 SM00490 SM00573 SM00951
SUPFAM	SSF47370 SSF52540
PROSITE	PS00633 PS50014 PS51192 PS51194 PS51204 PS51666

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060805	negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter	PMID:20485553^[1]	ECO:0000315			P		Figure 1. Shows Brg1 is required for Oct4 mRNA repression. Transcriptional regulation. Brg1 knockouts have higher levels of Oct4 mRNA.	complete CACAO 7443
part_of	GO:0016514	SWI/SNF complex	PMID:29374058^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16245309^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22162999^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22162999^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070182	DNA polymerase binding	PMID:19571879^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O70372	F		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	PMID:19571879^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26138476^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071565	nBAF complex	PMID:17640523^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071564	npBAF complex	PMID:17640523^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:17640523^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:18267097^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450311,MGI:MGI:3605892	P	occurs_in:(EMAPA:16351)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022008	neurogenesis	PMID:22513373^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:20176728^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:22513373^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	PMID:16287714^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039)	Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	C		Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621728	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010424	DNA methylation on cytosine within a CG sequence	PMID:16287714^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3611933	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3605892	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15767674^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q03267	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:18267097^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450311,MGI:MGI:3605892	P	results_in_development_of:(EMAPA:16351)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007403	glial cell fate determination	PMID:16330018^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:3605892	P	occurs_in:(EMAPA:17544) results_in_determination_of:(CL:0000030)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006346	methylation-dependent chromatin silencing	PMID:16322236^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97171)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	PMID:16287714^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3611933	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006337	nucleosome disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006337	nucleosome disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621728	P		Seeded From UniProt	complete
NOT\|part_of	GO:0005730	nucleolus	PMID:10318760^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005726	perichromatin fibrils	PMID:10318760^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:10318760^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9603422^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18267097^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16880268^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16787967^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16192310^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16405) part_of:(CL:0000312)\|part_of:(EMAPA:16096) part_of:(CL:0000114)\|part_of:(EMAPA:16096) part_of:(CL:0000114)\|part_of:(EMAPA:16405) part_of:(CL:0000114)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15565649^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000062)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10318760^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621728	C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18267097^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:109249)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:17074803^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:107606)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16322236^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:97171)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16287714^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:10318760^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621728	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003281	ventricular septum development	PMID:25807483^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003151	outflow tract morphogenesis	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3605892	P		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	PMID:16287714^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386105 MGI:MGI:3611933	P	results_in_development_of:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001835	blastocyst hatching	PMID:11163203^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386105	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001832	blastocyst growth	PMID:11163203^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386105	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3605892	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:16287714^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386105 MGI:MGI:3611933	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:18267097^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450311,MGI:MGI:3605892	P	occurs_in:(EMAPA:16370)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3605892	P		Seeded From UniProt	complete
enables	GO:0001164	RNA polymerase I CORE element sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:23319608^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:20176728^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	PMID:16287714^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386105 MGI:MGI:3611933	P		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:16322236^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18267097^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450311,MGI:MGI:3605892	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16322236^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97171)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902661	positive regulation of glucose mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
part_of	GO:0071565	nBAF complex	PMID:23785148^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071564	npBAF complex	PMID:23785148^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071564	npBAF complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	C		Seeded From UniProt	complete
enables	GO:0070577	lysine-acetylated histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070307	lens fiber cell development	PMID:21118511^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386105	P		Seeded From UniProt	complete
enables	GO:0070182	DNA polymerase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061626	pharyngeal arch artery morphogenesis	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3605892	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060976	coronary vasculature development	PMID:25807483^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060766	negative regulation of androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060347	heart trabecula formation	PMID:18267097^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109249	P	has_participant:(EMAPA:16350)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060318	definitive erythrocyte differentiation	PMID:16287714^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3611933	P	results_in_acquisition_of_features_of:(CL:0002355)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048730	epidermis morphogenesis	PMID:16192310^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177413,MGI:MGI:3605892	P	has_participant:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048562	embryonic organ morphogenesis	PMID:16287714^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386105 MGI:MGI:3611933	P	has_participant:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19342595^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2137495	P	regulates_o_occurs_in:(EMAPA:35135) regulates_o_occurs_in:(CL:0000192) has_regulation_target:(MGI:MGI:894806)\|regulates_o_occurs_in(EMAPA:35135) regulates_o_occurs_in:(CL:0000192) has_regulation_target:(MGI:MGI:102643)\|regulates_o_occurs_in(EMAPA:35135) regulates_o_occurs_in:(CL:0000192) has_regulation_target:(MGI:MGI:104979)\|regulates_o_occurs_in(EMAPA:35135) regulates_o_occurs_in:(CL:0000192) has_regulation_target:(MGI:MGI:106012)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3605892	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16287714^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3611933	P	has_regulation_target:(MGI:MGI:96021)\|has_regulation_target:(MGI:MGI:96022)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621728	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043966	histone H3 acetylation	PMID:16287714^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3611933	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043923	positive regulation by host of viral transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043388	positive regulation of DNA binding	PMID:19342595^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2137495	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3605892	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043044	ATP-dependent chromatin remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035904	aorta development	PMID:25807483^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035887	aortic smooth muscle cell differentiation	PMID:19342595^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:35135) results_in_acquisition_of_features_of:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035116	embryonic hindlimb morphogenesis	PMID:16192310^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177413,MGI:MGI:3605892	P	results_in_development_of:(EMAPA:17251)	Seeded From UniProt	complete
enables	GO:0030957	Tat protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030902	hindbrain development	PMID:16330018^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:3605892	P	results_in_development_of:(EMAPA:35211)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:16330018^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:3605892	P	results_in_development_of:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:23319608^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3605892	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51532	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030216	keratinocyte differentiation	PMID:16192310^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177413,MGI:MGI:3605892	P	occurs_in:(EMAPA:17528) results_in_acquisition_of_features_of:(CL:0000312)	Seeded From UniProt	complete
involved_in	GO:0001188	RNA polymerase I preinitiation complex assembly	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001164	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000330 InterPro:IPR014978	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014978	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014978	P		Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030100	C		Seeded From UniProt	complete
enables	GO:0016817	hydrolase activity, acting on acid anhydrides	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006576	F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030100	F		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029295	F		Seeded From UniProt	complete
involved_in	GO:0043044	ATP-dependent chromatin remodeling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030100	P		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:11163203^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	PMID:11163203^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006334	nucleosome assembly	PMID:11163203^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wang, K et al. (2010) Brg1 is required for Cdx2-mediated repression of Oct4 expression in mouse blastocysts. PLoS ONE 5 e10622 PubMed GONUTS page
↑ Alpsoy, A & Dykhuizen, EC (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J. Biol. Chem. 293 3892-3903 PubMed GONUTS page
↑ Giacinti, C et al. (2006) MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions. J. Cell. Physiol. 206 807-13 PubMed GONUTS page
↑ ^4.0 ^4.1 Vizlin-Hodzic, D et al. (2011) SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription. PLoS ONE 6 e28049 PubMed GONUTS page
↑ ^5.0 ^5.1 Park, JI et al. (2009) Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460 66-72 PubMed GONUTS page
↑ Cajigas, I et al. (2015) Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling. Development 142 2641-52 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Lessard, J et al. (2007) An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55 201-15 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Stankunas, K et al. (2008) Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev. Cell 14 298-311 PubMed GONUTS page
↑ ^9.0 ^9.1 Ahmed, M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development 139 1965-77 PubMed GONUTS page
↑ ^10.0 ^10.1 Kidder, BL & Palmer, S (2010) Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 20 458-72 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 Bultman, SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 19 2849-61 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 Li, W et al. (2013) Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. Proc. Natl. Acad. Sci. U.S.A. 110 1738-43 PubMed GONUTS page
↑ Gómez-del Arco, P et al. (2005) Ikaros SUMOylation: switching out of repression. Mol. Cell. Biol. 25 2688-97 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Matsumoto, S et al. (2006) Brg1 is required for murine neural stem cell maintenance and gliogenesis. Dev. Biol. 289 372-83 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Datta, J et al. (2005) Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. Cancer Res. 65 10891-900 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Remboutsika, E et al. (1999) The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J. Cell. Sci. 112 ( Pt 11) 1671-83 PubMed GONUTS page
↑ LeGouy, E et al. (1998) Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein. Dev. Dyn. 212 38-48 PubMed GONUTS page
↑ Torres-Padilla, ME & Zernicka-Goetz, M (2006) Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J. Cell Biol. 174 329-38 PubMed GONUTS page
↑ Costa, Y et al. (2006) Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway? Hum. Mol. Genet. 15 2324-34 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Indra, AK et al. (2005) Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation. Development 132 4533-44 PubMed GONUTS page
↑ Young, DW et al. (2005) SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J. Cell. Biochem. 94 720-30 PubMed GONUTS page
↑ Lee, YS et al. (2007) Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. Mol. Cell. Biol. 27 438-52 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 Bultman, S et al. (2000) A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol. Cell 6 1287-95 PubMed GONUTS page
↑ ^25.0 ^25.1 Staahl, BT et al. (2013) Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J. Neurosci. 33 10348-61 PubMed GONUTS page
↑ He, S et al. (2010) Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin 3 21 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Zhou, J et al. (2009) The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression. Arterioscler. Thromb. Vasc. Biol. 29 921-8 PubMed GONUTS page

[PMID:20485553-1] Wang, K et al. (2010) Brg1 is required for Cdx2-mediated repression of Oct4 expression in mouse blastocysts. PLoS ONE 5 e10622 PubMed GONUTS page

[PMID:29374058-2] Alpsoy, A & Dykhuizen, EC (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J. Biol. Chem. 293 3892-3903 PubMed GONUTS page

[PMID:16245309-3] Giacinti, C et al. (2006) MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions. J. Cell. Physiol. 206 807-13 PubMed GONUTS page

[PMID:22162999-4] 4.0 ^4.1 Vizlin-Hodzic, D et al. (2011) SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription. PLoS ONE 6 e28049 PubMed GONUTS page

[PMID:19571879-5] 5.0 ^5.1 Park, JI et al. (2009) Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460 66-72 PubMed GONUTS page

[PMID:26138476-6] Cajigas, I et al. (2015) Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling. Development 142 2641-52 PubMed GONUTS page

[PMID:17640523-7] 7.0 ^7.1 ^7.2 Lessard, J et al. (2007) An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55 201-15 PubMed GONUTS page

[PMID:18267097-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Stankunas, K et al. (2008) Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev. Cell 14 298-311 PubMed GONUTS page

[PMID:22513373-9] 9.0 ^9.1 Ahmed, M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development 139 1965-77 PubMed GONUTS page

[PMID:20176728-10] 10.0 ^10.1 Kidder, BL & Palmer, S (2010) Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 20 458-72 PubMed GONUTS page

[PMID:16287714-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 Bultman, SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 19 2849-61 PubMed GONUTS page

[PMID:23319608-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 Li, W et al. (2013) Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. Proc. Natl. Acad. Sci. U.S.A. 110 1738-43 PubMed GONUTS page

[PMID:15767674-13] Gómez-del Arco, P et al. (2005) Ikaros SUMOylation: switching out of repression. Mol. Cell. Biol. 25 2688-97 PubMed GONUTS page

[PMID:16330018-14] 14.0 ^14.1 ^14.2 Matsumoto, S et al. (2006) Brg1 is required for murine neural stem cell maintenance and gliogenesis. Dev. Biol. 289 372-83 PubMed GONUTS page

[PMID:16322236-15] 15.0 ^15.1 ^15.2 ^15.3 Datta, J et al. (2005) Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. Cancer Res. 65 10891-900 PubMed GONUTS page

[PMID:10318760-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Remboutsika, E et al. (1999) The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J. Cell. Sci. 112 ( Pt 11) 1671-83 PubMed GONUTS page

[PMID:9603422-17] LeGouy, E et al. (1998) Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein. Dev. Dyn. 212 38-48 PubMed GONUTS page

[PMID:16880268-18] Torres-Padilla, ME & Zernicka-Goetz, M (2006) Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J. Cell Biol. 174 329-38 PubMed GONUTS page

[PMID:16787967-19] Costa, Y et al. (2006) Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway? Hum. Mol. Genet. 15 2324-34 PubMed GONUTS page

[PMID:16192310-20] 20.0 ^20.1 ^20.2 ^20.3 Indra, AK et al. (2005) Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation. Development 132 4533-44 PubMed GONUTS page

[PMID:15565649-21] Young, DW et al. (2005) SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J. Cell. Biochem. 94 720-30 PubMed GONUTS page

[PMID:17074803-22] Lee, YS et al. (2007) Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. Mol. Cell. Biol. 27 438-52 PubMed GONUTS page

[PMID:25807483-23] 23.0 ^23.1 ^23.2 Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page

[PMID:11163203-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 Bultman, S et al. (2000) A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol. Cell 6 1287-95 PubMed GONUTS page

[PMID:23785148-25] 25.0 ^25.1 Staahl, BT et al. (2013) Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J. Neurosci. 33 10348-61 PubMed GONUTS page

[PMID:21118511-26] He, S et al. (2010) Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin 3 21 PubMed GONUTS page

[PMID:19342595-27] 27.0 ^27.1 ^27.2 Zhou, J et al. (2009) The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression. Arterioscler. Thromb. Vasc. Biol. 29 921-8 PubMed GONUTS page

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MOUSE:SMCA4

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